In vivo animal studies with sugammadex

Booij, L.H.D.J.; Egmond, J. van; Driessen, J. J.; Boer, Hans D. de

doi:10.1111/j.1365-2044.2008.05869.x

Cited by 22 publications

(19 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reversal of rocuronium-induced neuromuscular block by sugammadex has been demonstrated through in vivo experiments in several animal species (Booij et al 2009;de Boer et al 2006). Within the literature search limits of this study, there were no articles found that were directly related to rocuronium and sugammadex-induced histopathologic changes in rat testis tissues.…”

Section: Discussionmentioning

confidence: 77%

Effects of sugammadex on immunoreactivity of calcineurin in rat testes cells after neuromuscular block: a pilot study

et al. 2011

View full text Add to dashboard Cite

Reversal of neuromuscular blockage induced by steroidal neuromuscular blocking agents such as rocuronium can be achieved using normal dose of sugammadex, which has been shown to be very effective for such reversal. In this study, we determined the effects of sugammadex on calcineurin immunoreactivity by examining the histopathological and histochemical structure of rat testis cells after neuromuscular blockage. Moreover, the regional distribution levels of calcineurin immunopositive testes cells were investigated. Eighteen adult male, Sprague-Dawley rats were divided into one control and two study groups. Study groups 1 and 2 rats received sugammadex at doses of 16 and 96 mg kg(-1) i.v., respectively, after rocuronium treatment (mg kg(-1) i.v.). The control group received intravenous 0.9% NaCl 1 ml. i.v without any drug. Our study demonstrates that sugammadex is safe and effective for reversal of rocuronium effects in rats, as well as in other animals and humans. Furthermore, histopathological examination indicates that high levels of sugammadex-rocuronium complexes accumulate a little in testis tissue. We found that rocuronium-sugammadex complexes were remained in circulation for a long time resulting in a decrease in interstitial space, testis size, germ cell numbers and Leydig cell numbers. Calcineurin immunoreactivity was higher in the experimental groups than the control group due to increase of calcium level. The results suggest that sugammadex-rocuronium complexes are cause histopathological and immunohistochemical changes in testis interstitial tissues, as well as changes in sperm density and germ cell number.

show abstract

Section: Discussionmentioning

confidence: 77%

Effects of sugammadex on immunoreactivity of calcineurin in rat testes cells after neuromuscular block: a pilot study

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Again, the doses of rocuronium and vecuronium are different from humans. Nevertheless, these experiments showed that the train-of-four ratio reached the target value of 0.9 rapidly after sugammadex when complete blockade was produced by rocuronium or vecuronium, but there was no effect if blockade was produced by benzylisoquinoline compounds such as atracurium or mivacurium [11]. It was also established that the plasma concentration of rocuronium increased after injection of sugammadex [13].…”

Section: Animal Studiesmentioning

confidence: 98%

“…However, this effect is compensated by the lower affinity, so that in practice, the sugammadex dose requirements are approximately the same for both vecuronium and rocuronium. It seems that pancuronium, which has a potency similar to that of vecuronium, has even less affinity for sugammadex, and little experimental work has been performed with the combination [11].…”

Section: Interactions Between Neuromuscular Blocking Agents and Sugammentioning

confidence: 99%

Sugammadex: A Cyclodextrin‐Based Novel Formulation and Marketing Story

Donati

2011

Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine

View full text Add to dashboard Cite

“…The selectivity of sugammadex specific for steroidal NMBDs was studied in guinea pigs and primates as well. [22,23] During the in vivo experiments to determine the reversal effect of sugammadex in anesthetized animals, blood pressure and heart rate were continuously monitored. No changes in arterial blood pressure and heart rate were observed after the intravenous application of sugammadex [ Table 2].…”

Section: Elderly Patientsmentioning

confidence: 99%

Sugammadex - A short review and clinical recommendations for the cardiac anesthesiologist

et al. 2010

View full text Add to dashboard Cite

This review outlines the basic pharmacodynamic and pharmacokinetic properties of sugammadex for the cardiac anesthesiologist. It describes the different clinical scenarios when sugammadex can be used during cardiac surgery and gives clinical recommendations. Sugammadex is a unique reversal drug that binds a chemical complex with rocuronium and vecuronium, by which the neuromuscular blockade is quickly reversed. It is free of any clinical side-effects and doses of 2 mg/kg or more reliably reverse neuromuscular blockade within 5-15 min, depending on the depth of the neuromuscular blockade. Doses below 2 mg/kg should be avoided at any time because of the inherent risk of recurarization. Sugammadex should not replace good clinical practice--titration of neuromuscular blocking drugs to clinical needs and objective monitoring of neuromuscular blockade in the operating room or intensive care unit. Neuromuscular transmission should be determined in all patients before sugammadex is considered and 5 min after its administration to ensure that extubation is performed with normal neuromuscular transmission.

show abstract

In vivo animal studies with sugammadex

Cited by 22 publications

References 38 publications

Effects of sugammadex on immunoreactivity of calcineurin in rat testes cells after neuromuscular block: a pilot study

Effects of sugammadex on immunoreactivity of calcineurin in rat testes cells after neuromuscular block: a pilot study

Sugammadex: A Cyclodextrin‐Based Novel Formulation and Marketing Story

Sugammadex - A short review and clinical recommendations for the cardiac anesthesiologist

Contact Info

Product

Resources

About