In vivo and in vitro toxicity of a stainless-steel aerosol generated during thermal spray coating

Kodali, Vamsi; Afshari, Abbas; Meighan, Terence; McKinney, Walter; Mazumder, Md Habibul Hasan; Majumder, Nairrita; Cumpston, Jared L.; Leonard, Howard D.; Cumpston, James B.; Friend, Sherri; Leonard, Stephen S.; Erdely, Aaron; Zeidler-Erdely, Patti C.; Hussain, Salik; Lee, Eun Gyung; Antonini, James M.

doi:10.1007/s00204-022-03362-7

Cited by 6 publications

(2 citation statements)

References 43 publications

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“…-ROS, NF-kb (>3.12ug/mL) (Kodali et al, 2022) RAW 264.7 PM2.5, 400mg/mL, 24h, SUB -ROS, MDA, NLRP3, NF-kb, Bax, apoptotic rate, caspase-1, caspase-3, GSDMD, IL-1β, %cells in G2 ¯ Bcl-2, SOD act., %cells in G1 (Ren et al, 2022) RAW 264.7 PM (China) urban aerossol, 30mg/cm 2 , 24h, SUB -ROS, TNF-a, IL-1b, IL-6, MIP-2 (Tanaka et al, 2022) diff U937 (as alveolar macrophages), HMC3…”

Section: Mechanisms Of Pm-induced Oxidative Stress-related Respirator...mentioning

confidence: 99%

“…cyclooxygenase-2, COX-2), which trigger the onset of the inflammatory process (Millar et al, 2022). While increased expression and activation of NF-kB has been widely reported as a consequence of PM-exposure (Chen et al, 2020;Kodali et al, 2022;Meganathan et al, 2022;Ren et al, 2022;Shrestha et al, 2021;Wang et al, 2022aWang et al, , 2022d only a few works have proven its derivation from increased ROS, as compounds with antioxidant activity could reverse such effect (Meganathan et al, 2022;Ren et al, 2022;Wang et al, 2022a). Along with its pivotal role in inflammation, NF-kB has shown to promote tissue repair and airway remodeling via epithelial-mesenchymal transition (EMT), an underlying process in many fibrotic lung diseases and cancer (Rout-Pitt et al, 2018).…”

Section: Activation Of the Inflammatory Response And Its Consequencesmentioning

confidence: 99%

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Particulate Matter-Induced Oxidative Stress – Recent Mechanistic Insights from In Vitro Studies

Vilas-Boas,

Chatterjee,

Carvalho

et al. 2024

Preprint

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Inhaled particulate matter (PM) is a key player in the millions of yearly deaths worldwide related to air pollution. The oxidative potential of PM provides an indication of its ability to promote an oxidative environment. When the human lungs are exposed to PM, the reactive oxygen species (ROS) generated in such oxidative environment, if excessive, may lead to cell damage via oxidative stress. Inflammation, endoplasmic reticulum stress, airway remodeling, and many different cell death modes (apoptosis, ferroptosis, pyroptosis, among others) can be triggered by oxidative stress via complex molecular pathways, which also involve the adaptive cellular response. But ROS can also directly interact with macromolecules such as proteins and lipids, as well as nucleic acids, having been reported to induce DNA damage and epigenetic modifications, which jeopardizes homeostasis. These facts have been extensively studied in in vitro models and confirmed in in vivo models.In this review, we delve beyond conventional assessments of airborne particles, discussing their oxidative potential and the PM-induced ROS-mediated cellular damage observed in in vitro models. The close link between oxidative stress and inflammation, and the manifestation of different cell death modes is highlighted by reviewing the latest literature. The effects of ROS on the balance of DNA damage and repair, carcinogenicity and epigenetics interplay are then analyzed. Finally, we expand on the latest reports on the antioxidants’ potential to counteract the deleterious effects of ROS, and disclose future perspectives for the topic.

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Section: Mechanisms Of Pm-induced Oxidative Stress-related Respirator...mentioning

confidence: 99%

Section: Activation Of the Inflammatory Response And Its Consequencesmentioning

confidence: 99%

Particulate Matter-Induced Oxidative Stress – Recent Mechanistic Insights from In Vitro Studies

Vilas-Boas,

Chatterjee,

Carvalho

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Immunotoxicity of stainless-steel nanoparticles obtained after 3D printing

Olšovská,

Mikušová,

Tulinská

et al. 2024

Ecotoxicology and Environmental Safety

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Particulate matter-induced oxidative stress – Mechanistic insights and antioxidant approaches reported in in vitro studies

Vilas-Boas,

Chatterjee,

Carvalho

et al. 2024

Environmental Toxicology and Pharmacology

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In vivo and in vitro toxicity of a stainless-steel aerosol generated during thermal spray coating

Cited by 6 publications

References 43 publications

Particulate Matter-Induced Oxidative Stress – Recent Mechanistic Insights from In Vitro Studies

Particulate Matter-Induced Oxidative Stress – Recent Mechanistic Insights from In Vitro Studies

Immunotoxicity of stainless-steel nanoparticles obtained after 3D printing

Particulate matter-induced oxidative stress – Mechanistic insights and antioxidant approaches reported in in vitro studies

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