In Vivo and in Vitro Modifications of Platelet Aggregation and Release of ATP by Ionic and Nonionic Contrast Media Used in Angiography

Belleville, J; Cornillon, Bernard; Freyria, Anne‐Marie; Amiel, M; Pinet, A; Eloy, R.

doi:10.1007/978-3-642-68584-2_10

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Various effects of contrast media on platelet function have been reported. Thus, induction of platelet granule release by contrast agents has been described, [ 1,2] and platelets incubated in vitro with contrast media have been shown to undergo striking pseudopod formation and to form aggregates of various sizes.…”

Section: Introductionmentioning

confidence: 99%

Radiographic contrast agents and platelet function: A quenched‐flow study

Taylor

Angello

Ayers

et al. 1991

Cathet. Cardiovasc. Diagn.

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Radiographic contrast media (RCM) may alter platelet behavior at concentrations achieved during cardiac angiography. We used quenched-flow aggregometry coupled to single-particle counting to study the influence of RCM on the kinetics of platelet aggregation (less than 5.0 sec) induced by adenosine diphosphate (ADP, 2.86 microM). At a concentration in platelet-rich plasma (PRP) of 5 per cent RCM by volume, platelet aggregation was inhibited by diatrizoate, iopamidol and ioxaglate either directly or following incubation of each contrast agent with PRP for 20 minutes. Diatrizoate inhibited more than did iopamidol or ioxaglate (56 +/- 6, versus 39 +/- 3 and 40 +/- 9 per cent respectively; P less than 0.003, p less than 0.009, n = 20 normal subjects). A small reduction (about 16 per cent) in aggregation velocity occurred within 5 seconds of exposure of PRP to all 3 RCM and the onset time (t) or lag period before aggregation begins was significantly prolonged by diatrizoate (p less than 0.03). The RCM vehicles alone (iodinated moiety removed, osmolality readjusted) had no effect on the ADP-induced aggregation. Platelet counts fell significantly after incubation with diatrizoate (12%; p = 0.04). Our data therefore show that early platelet aggregation was inhibited by 3 commonly-used ionic and nonionic contrast agents. Inhibition was apparently caused by the iodinated contrast molecule, began within seconds of platelet-RCM contact and was independent of vehicle composition. Since diatrizoate inhibited aggregation more than iopamidol or ioxaglate, its use may be of additional value during angiographic procedures in clinical situations involving enhanced platelet activation.

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Section: Introductionmentioning

confidence: 99%

Radiographic contrast agents and platelet function: A quenched‐flow study

Taylor

Angello

Ayers

et al. 1991

Cathet. Cardiovasc. Diagn.

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“…Also, the incidence of systemic reactions after intravenous injection is presumably lower with non-ionic contrast media (17,28), although no difference in this respect was found in a recent investigation (15). However, since both ionic and non-ionic contrast media cause heat sensation, flushing, vasodilation, and nausea, and have anticoagulant properties (2,29,40), the possible role of endothelium-derived prostacyclin as a mediator of these reactions is not totally excluded.…”

Section: Discussionmentioning

confidence: 98%

Effect of Contrast Media on the Formation of Prostacyclin in Isolated Rat Lungs

Paajanen¹,

Uotila²

1985

Acta Radiologica. Diagnosis

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The synthesis of prostacyclin (PGI2) was studied in isolated perfused rat lungs during the infusion of radiographic contrast media into the pulmonary circulation. At the same molar concentration, diatrizoate, iopamidol, and NaCl fairly equally stimulated the generation of PGI2. A bolus injection of histamine also enhanced the formation of PGI2. A high dose of ionic diatrizoate and hypertonic saline (0.4 mol/l) caused considerable pulmonary edema, which was less marked with non-ionic iopamidol. Experiments with 125I-labeled contrast media indicated rapid efflux of contrast media from the lungs. The present investigation indicates that different contrast media stimulate the synthesis of prostacyclin mainly because of chemical irritation of the pulmonary endothelium. The enhanced formation of endothelium-derived prostacyclin may mediate some systemic and local side effects seen temporarily during intravascular contrast medium examinations.

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“…Interaction and disturbance of the coagulation and fibrinolytic systems or in the platelet aggregation capacity have been recorded in vitro using high concentrations of contrast media (18,24,33,41), and in vivo using large doses of contrast media (4,20,33,35,41). Some of these changes have been reported to be due to the cation in the contrast medium, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…sodium or meglumine (18,24). Ioxaglate has also been reported to interfere with the coagulation and fibrinolytic system and platelets both in vitro and in vivo (4,9,27,32,37). The reported changes were transient and did not induce any disturbances of clinical importance.…”

Section: Discussionmentioning

confidence: 99%

Tolerance and Biochemical Effects from Intravenous Injection of Ioxaglate in Healthy Volunteers

Nilsson¹,

Aspelin²,

Nyman³

et al. 1984

Acta Radiologica. Diagnosis

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The influence of intravenous injection of ioxaglate (Hexabrix, 320 mg 11m!) on various biochemical, coagulation and fibrinolytic parameters, fractionated plasma proteins, precordial ECG and blood pressure was prospectively and sequentially studied in 9 healthy volunteers. One ml/kg body weight of the contrast medium was injected within one minute into an antecubital vein. Small, but statistically significant, changes in some of the biochemical parameters were found during the observation period, 2 to 4 days. All values of the biochemical parameters were, however, within the normal reference range for each parameter. No significant alterations were seen in the coagulation parameters. Increased fibrinolysis was recorded in some subjects both before and after the injection. No fibrinolytic degradation products were found indicating that the fibrinolysis was nominal. No significant changes were observed in the fractionated plasma proteins. The heart rate decreased significantly 15 seconds after commencing the injection. No significant changes in blood pressure were recorded. Two participants became nauseated and one of them vomited during the injection. Apart from this, no adverse effects were noted. No clinically significant changes following the injections were found.

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In Vivo and in Vitro Modifications of Platelet Aggregation and Release of ATP by Ionic and Nonionic Contrast Media Used in Angiography

Cited by 5 publications

References 6 publications

Radiographic contrast agents and platelet function: A quenched‐flow study

Radiographic contrast agents and platelet function: A quenched‐flow study

Effect of Contrast Media on the Formation of Prostacyclin in Isolated Rat Lungs

Tolerance and Biochemical Effects from Intravenous Injection of Ioxaglate in Healthy Volunteers

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