In vivo and in vitro anti-hepatitis B virus activity of total phenolics from Oenanthe javanica

Han, Yan-Quan; Huang, Zheng‐Ming; Yang, Xinbo; Liu, He-Zhi; Wu, Guang-xia

doi:10.1016/j.jep.2008.03.024

Cited by 68 publications

(40 citation statements)

References 14 publications

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“…Caffeic acid isolated from O. javanica is reported to have hepatoprotective activity 6,7 . Phenolic obtained from the plant showed antihepatitis B virus activity 8 . O. javanica is commonly consumed in the North-eastern State of India, Manipur.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity, Total Phenolic and Total Flavonoid Content of Oenanthe Javanica Blume (Dc) Collected From Imphal West District

Bhaigyabati¹,

Devi²,

Chvi³

et al. 2017

Int. Res. J. Pharm.

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Oenanthe javanica Blume (DC) is an aromatic medicinal herb having pharmacological properties such as antioxidant, anti-quorum sensing, anticoagulant, antitoxic, hepatoprotective, anti-hepatitis B virus and memory improvement. It is one of the most consumed vegetable throughout the year in Manipur. The present study was carried out to analyze the phytochemical constituents, antioxidant activity and total phenolic and total flavonoid content of Oenanthe javanica. Preliminary phytochemical analysis was done using standard procedure. Total phenolic, total flavonoid content and antioxidant activities were determined spectrophotometrically in crude aqueous and methanolic extracts. Preliminary phytochemical analysis indicates the presence of amino acids, carbohydrates, proteins, flavonoids, phenolic compounds, steroids and terpenoids, saponins, tannins, cardiac glycosides except alkaloids and phlobatannins. The present study demonstrates the antioxidant activity of Oenanthe javanica Blume (DC) due to the various phytochemicals present in the extract which confer their traditional uses as food and medicine.

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Section: Introductionmentioning

confidence: 99%

Antioxidant Activity, Total Phenolic and Total Flavonoid Content of Oenanthe Javanica Blume (Dc) Collected From Imphal West District

Bhaigyabati¹,

Devi²,

Chvi³

et al. 2017

Int. Res. J. Pharm.

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show abstract

“…Han's research group used the HepG2.2.15 cell line and a model of DHBV infection to evaluate the anti-HBV effects of an ethanol extract of O. javanica. Results indicated that O. javanica suppressed HBsAg and HBeAg in vitro and that it also inhibited DHBV replication in duck models (21).…”

Section: Cells (19)mentioning

confidence: 97%

Advance in studies on traditional Chinese medicines to treat infection with the hepatitis B virus and hepatitis C virus

Xia

Inagaki

Song

et al. 2016

BST

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“…O. javanica , which contains high levels of vitamins and minerals, is consumed as a vegetable, and has also been used as a medicinal agent. It has a long history of use for the treatment of inflammatory conditions, including hepatitis (8,9). Hyperoside, persicarin and isorhamnetin are the three major substances with pharmacological activities that have been identified in O. javanica .…”

Section: Introductionmentioning

confidence: 99%

“…Hyperoside, persicarin and isorhamnetin are the three major substances with pharmacological activities that have been identified in O. javanica . These substances have been shown to possess hepatoprotective, antithrombotic, antiarrhythmic, antidiabetic, antihepatitis B virus, neuroprotective and anticancer activities (9–16). …”

Section: Introductionmentioning

confidence: 99%

Persicarin isolated from Oenanthe javanica protects against diabetes-induced oxidative stress and inflammation in the liver of streptozotocin-induced type 1 diabetic mice

Lee

Kim

Shin

et al. 2017

Experimental and Therapeutic Medicine

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Persicarin is one of the major components of the Oenanthe javanica (water dropwort). The present study was aimed to evaluate the role of persicarin in the hepatic tissue of streptozotocin-induced type 1 diabetic mice. Diabetes was induced by single intra-peritoneal injection of streptozotocin (120 mg/kg body weight) and then oral administration of persicarin at a dose 2.5 and 5 mg/kg body weight for 10 days. Serum and hepatic glucose levels were increased in diabetic control mice, while persicarin treatment groups were markedly reduced. Also, the increased levels of ALT and AST in serum were improved by persicarin. In our results revealed that persicarin suppressed increased oxidative stress parameter (reactive oxygen species, peroxinitrite, and thiobarbituric acid-reactive substance), nicotinamide adenine dinucleotide phosphate oxidase subunit (Nox-4 and P47phox) and inflammatory related makers (NF-κB, AP-1, TGF-β, COX-2, and iNOS). These results suggest that persicarin protects against liver damage by attenuating oxidative stress and inflammatory response under hyperglycemic conditions. Thus, persicarin could perform as a potential therapeutic agent for the treatment of diabetic mellitus.

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In vivo and in vitro anti-hepatitis B virus activity of total phenolics from Oenanthe javanica

Cited by 68 publications

References 14 publications

Antioxidant Activity, Total Phenolic and Total Flavonoid Content of Oenanthe Javanica Blume (Dc) Collected From Imphal West District

Antioxidant Activity, Total Phenolic and Total Flavonoid Content of Oenanthe Javanica Blume (Dc) Collected From Imphal West District

Advance in studies on traditional Chinese medicines to treat infection with the hepatitis B virus and hepatitis C virus

Persicarin isolated from Oenanthe javanica protects against diabetes-induced oxidative stress and inflammation in the liver of streptozotocin-induced type 1 diabetic mice

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