In vivo and in vitro Pharmacological Evaluation of Gymnosporia royleana

Khan, Hasan; Shad, AA; Khan, IA; Aziz, Al Thabiani; Ghasemzadeh, Ali; Hizbullah, SM; Jan, Ifat

doi:10.7727/wimj.2015.459

Cited by 2 publications

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“…On the other hand, there was no antibacterial activity for the methanolic extracts from O. baccatus flowers and whole plant. Similar results have also been reported in previous studies [ 11 , 12 , 13 , 14 ]. Therefore, it could be clearly observed that the root and branch methanolic extracts demonstrated antibacterial activity, and the highest activity was exerted by the branch extract against Escherichia coli and Salmonella typhimurium (S t ).…”

Section: Discussionsupporting

confidence: 92%

Chemical Composition, Antibacterial Activity and In Vitro Anticancer Evaluation of Ochradenus baccatus Methanolic Extract

et al. 2023

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Background and Objectives: Ochradenus baccatus belongs to the family Resedaceae. It is widely spread in Saudi Arabia and other countries in Southwest Asia. O. baccatus is extensively used in traditional medicine as an anti-inflammatory and antibacterial agent, in addition to being a vital source of food for certain desert animal species. The aim of the present study was to investigate the chemical composition and antibacterial/anticancer activities of O. baccatus methanolic extracts collected from Hail, Saudi Arabia. Materials and Methods: The O. baccatus extracts were obtained by macerating the crude powder in methanol, followed by filtration and evaporation. Liquid chromatography–mass spectrometry (LC-MS) was used to analyze the methanolic extracts’ chemical constituents. Broth microdilution assay for minimum inhibitory concentration (MIC) determination was used to assess antimicrobial activity, while the extracts’ anticancer potential was assessed by sulforhodamine B Assay (SRB) assay. Results: The results of the antibacterial assay showed that the methanolic extracts from the roots and branches possessed varying degrees of activity against particular bacterial strains, with the highest activity being exerted by the branches’ extract against Escherichia coli and Salmonella typhimurium (St), demonstrating MIC values of 15.6 µg/mL and 20 µg/mL, respectively. Furthermore, the SRB cell viability assay revealed that only the branches’ extract inhibited the growth of A549 cancer cells, with an IC50 value of 86.19 µg/mL. The LC-MS analysis of the methanolic extracts from the plant’s roots and branches was then conducted, resulting in the identification of 8 and 13 major chemical constituents, respectively. Azelaic acid, β-amyrin, and phytanic acid are some of the bioactive compounds that were detected in the extracts via LC-MS, and they are thought to be responsible for the observed antibacterial/anticancer activity of O. baccatus methanolic extracts. Conclusions: This study confirmed the antibacterial/anticancer potential of O. baccatus methanolic extracts and analyzed their phytochemical constituents. Further isolation and biological screening are warranted to understand the therapeutic potential of O. baccatus.

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Section: Discussionsupporting

confidence: 92%

Chemical Composition, Antibacterial Activity and In Vitro Anticancer Evaluation of Ochradenus baccatus Methanolic Extract

et al. 2023

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“…The present study is a part of our major study to screen local flora of Khyber-Pakhtunkhwa (KP) (22), Pakistan in order to validate scientifically the ethnopharmacological uses of Tamarix aphylla.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Evaluation of Tamarix aphylla for Anti-inflammatory, Anti-pyretic and Anti-nociceptive Activities in Standard Animal Models

Iqbal¹,

Sirajuddin²,

Khan³

et al. 2017

West Indian Med J

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Objectives: The objective of this study was to assess anti-inflammatory, anti-pyretic and antinociceptive activities of methanol extract of Tamarix Aphylla (TAME) in experimental animal models. Methods: The TAME was evaluated via carrageenan induced edema and xylene induced ear edema models for anti-inflammatory, brewer yeast induced pyrexia model for anti-pyretic activity, hot plate and acetic acid induced writhing models for anti-nociceptive properties. Results: The outcomes indicated that TAME in inflammatory models at a dose level of 100 and 200 mg/ kg exhibited statistically significant anti-inflammatory activity 51.84 %/ 68.59 % and 36.00 % / 61.17 % respectively. Similarly, TAME exhibited the maximum antipyretic effect at a dose level of 100 and 200 mg/ kg, which was 2.08 % and 2.72 % respectively. Moreover, the TAME demonstrated maximum percent inhibitory activity with a dose of 400 mg/kg in writhing and hot plate tests which was 50.40 % and 46.56 % respectively. Conclusion: In conclusion, this study provides a pharmacological basis for the ethnopharmacological use of Tamarix aphylla as anti-inflammatory, anti-pyretic and analgesic herbal remedy.

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In vivo and in vitro Pharmacological Evaluation of Gymnosporia royleana

Cited by 2 publications

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Chemical Composition, Antibacterial Activity and In Vitro Anticancer Evaluation of Ochradenus baccatus Methanolic Extract

Chemical Composition, Antibacterial Activity and In Vitro Anticancer Evaluation of Ochradenus baccatus Methanolic Extract

Pharmacological Evaluation of Tamarix aphylla for Anti-inflammatory, Anti-pyretic and Anti-nociceptive Activities in Standard Animal Models

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