In Vivo and In Vitro Cardioprotective Effect of Gossypin Against Isoproterenol-Induced Myocardial Infarction Injury

Çınar, İrfan; Yayla, Muhammed; Tavacı, Taha; Toktay, Erdem; Uğan, Rüstem Anıl; Bayram, Pınar; Halici, Hamza

doi:10.1007/s12012-021-09698-3

Cited by 24 publications

(31 citation statements)

References 42 publications

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“…Moreover, the microscopic evaluation of the morphological changes shows that GC treatment could easily protect against the cardiotoxic effects of ISO. These results align with previous publications from Cinar et al, 2021 ; Sivasangari et al, 2019 where the antioxidant potential of gossypin and arbutin was responsible for their cardioprotective effects. In the intracellular ROS detection assay, it was found that GC pretreatment of the cells significantly reduced ISO treatment-induced ROS generation, thereby successfully protecting the cardiac cells from oxidative stress.…”

Section: Discussionsupporting

confidence: 93%

Cardioprotective potential of the antioxidant-rich bioactive fraction of Garcinia pedunculata Roxb. ex Buch.-Ham. against isoproterenol-induced myocardial infarction in Wistar rats

et al. 2022

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This Study aimed to characterise the phenolic compounds in Garcinia pedunculata extract and assess their potential antioxidant activity as well as its cardioprotective potential in isoproterenol-induced cardiac hypertrophy in an experimental animal model. In vitro antioxidant properties were determined using DPPH, ABTS, FRAP, PMD assays. In vitro lipid peroxidation experiment was also performed with heart tissues. Cardioprotective and cardiotoxicity effects were determined using the cell line studies. The cardioprotective effect of GP was assessed in a rat model of isoproterenol-(ISO-) induced cardiac hypertrophy by subcutaneous administration. Heart weight/tail length ratio and cardiac hypertrophy indicators were reduced after oral administration of GP. Additionally, GP reduced oxidative stress and heart inflammation brought on by ISO. In H9c2 cells, the antihypertrophic and anti-inflammatory effects of the extract of GP were seen in the presence of ISO, which were further supported by the in vivo observations. This study makes a compelling case for the possibility that supplementing with dried GP fruit can prevent heart hypertrophy by reducing oxidative stress and inflammation.

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Section: Discussionsupporting

confidence: 93%

Cardioprotective potential of the antioxidant-rich bioactive fraction of Garcinia pedunculata Roxb. ex Buch.-Ham. against isoproterenol-induced myocardial infarction in Wistar rats

et al. 2022

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“…These results suggest that XIST is closely related to the damage process in H9c2 cells. In addition, we found that QYDPs improved the oxidative stress and inflammation induced and promoted by ISO, which is consistent with the results of Cinar et al (33). These results suggest that the role of QYDPs in protecting H9c2 cells involves oxidative stress and inflammation, but the mechanism of action of XIST remains unclear.…”

Section: Discussionsupporting

confidence: 92%

Qishen Yiqi dropping pills improve isoproterenol-induced cardiomyocyte hypertrophy by regulating X-inactive specific transcript (XIST) expression in rats

Luo¹,

Chen²,

Chen³

et al. 2022

J Thorac Dis

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Background: This study aimed to explore the potential mechanism of Qishen Yiqi dropping pills (QYDPs) in the treatment of chronic heart failure (CHF) by regulating the expression of lncRNAs during CHF.Methods: Differences in the expression of the long non-coding RNA (lncRNA), X-inactive specific transcript (XIST), in an isoproterenol (ISO)-induced cardiomyocyte hypertrophy model treated with QYDPs was analyzed by reverse transcription quantitative polymerase chain reaction (RT-qPCR). A cell counting kit-8 (CCK8) assay, flow cytometry (FCM), and enzyme linked immunosorbent assay (ELISA) were used to analyze the protective effects of QYDPs on the proliferation rate, apoptosis, myocardial enzyme, oxidative stress, and inflammation of cardiomyocytes, as well as the molecular mechanism of XIST.Results: Our results showed that in the ISO-induced cardiomyocyte hypertrophy model, XIST expression and apoptosis were increased, the cell proliferation rate was decreased, and myocardial enzyme levels increased [i.e., increased lactate dehydrogenase (LDH) and creatine kinase (CK) levels].Furthermore, cellular oxidative stress [i.e., increased malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) levels] and inflammatory response [i.e., increased interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α protein secretion] were also promoted. QYDP treatment effectively mitigated the effects of ISO induction. Subsequently, we found that suppressing XIST expression reversed the effect of ISO induction, whereas overexpression (ov) of XIST enhanced the effect of ISO induction.Finally, this study confirmed that QYDP treatment improved the ISO-induced decrease in proliferation, apoptosis, and promotion of oxidative stress and inflammatory response in cardiomyocytes, whereas ov of XIST partially negated the effect of QYDPs.Conclusions: QYDPs protected H9c2 cells from ISO-induced damage by downregulating XIST expression.

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“…AST seviyeleri incelendiğinde LPS grubundaki AST seviyesinin sağlıklı gruba göre anlamlı şekilde arttığı görülmüştür (p<0,05). Akut veya kronik organ hasarları karaciğerin de dahil olduğu kalp, akciğer, böbrek, pankreas, beyin, gonadlar ve bağırsaklar gibi birçok organda görülebilir [45,[47][48][49]. Karaciğer enfeksiyöz olan veya olmayan birçok ajanla hasara uğrayabilir [50,51].…”

Section: Ast Ve Alt Sonuçları (Ast and Alt Results)unclassified

4 hidroksi fenilboronik asidin lipopolisakkarit ile indüklenmiş karaciğer hasarı üzerine muhtemel koruyucu etkilerinin incelenmesi

Bayraktutan¹

2022

Journal of Boron

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Bor ürünleri sağlık alanında uzun yıllardır kullanılmaktadır. Medikal anlamda ilk kez kanser tedavisinde kullanılan bor ürünleri yıllar içinde kardiyovasküler sağlık, kemik sağlığı, yara iyileşmesi ve immün sistem üzerine olan olumlu etkileri sebebiyle medikal tedavilerde yerini almıştır. Boronik asitler ise son zamanlarda medikal araştırmalarda oldukça popüler olarak incelenen bir bor bileşeni grubudur. Boronik asitler 100 yıldan daha uzun bir süredir sahip oldukları anti mikrobiyal etki ile biliniyorlardı. Ancak son zamanlarda yapılan çalışmalar boronik asitlerin sadece antimikrobiyal etkiye değil aynı zamanda anti enflamatuvar etkiye sahip olduklarını göstermiştir. Bu etkileriyle birçok enflamatuvar hastalıkta kullanılabilirler. Karaciğer hasarı da enflamasyonun görüldüğü hastalıklardan biridir. Son yıllarda, kanser, kemoterapiler, antiviral ilaçların kullanımı, artan hepatik steatoz ve yanlış bitkisel takviyelerin kullanımı sebebiyle karaciğer hasarı insidansı artmıştır. Bu sebeple karaciğer hasarının tedavi edilmesi günümüzde artık daha büyük önem arz etmektedir. Bu calışmada bir boronik asit türevi olan 4-hidroksi fenilboronik asidin lipopolisakkarit (LPS) ile indüklenmiş karaciğer hasarındaki rolü incelenmiştir. Sonuçlara bakıldığında 4 hidroksi fenilboronik asit tedavisinin artmış olan sitokin seviyelerini düşürdüğünü gözlemlenmiştir. Bu sonuçlara dayanarak 4-hidroksi fenilboronik asidin karaciğer hasarını tedavi etme potansiyeline sahip bir ajan olabileceği gösterilmiştir.

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In Vivo and In Vitro Cardioprotective Effect of Gossypin Against Isoproterenol-Induced Myocardial Infarction Injury

Cited by 24 publications

References 42 publications

Cardioprotective potential of the antioxidant-rich bioactive fraction of Garcinia pedunculata Roxb. ex Buch.-Ham. against isoproterenol-induced myocardial infarction in Wistar rats

Cardioprotective potential of the antioxidant-rich bioactive fraction of Garcinia pedunculata Roxb. ex Buch.-Ham. against isoproterenol-induced myocardial infarction in Wistar rats

Qishen Yiqi dropping pills improve isoproterenol-induced cardiomyocyte hypertrophy by regulating X-inactive specific transcript (XIST) expression in rats

4 hidroksi fenilboronik asidin lipopolisakkarit ile indüklenmiş karaciğer hasarı üzerine muhtemel koruyucu etkilerinin incelenmesi

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