In vivo and in vitro evaluation of the use of a newly developed melatonin loaded emulsion combined with UV filters as a protective agent against skin irradiation

Sierra, A.; Ramírez, María Laura; Campmany, Ana Cristina Calpena; Martínez, Adolfina Ruiz; Naveros, Beatriz Clarés

doi:10.1016/j.jdermsci.2012.10.013

Cited by 40 publications

(20 citation statements)

References 45 publications

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“…Among physical characteristics for dermal formulations pH is an important factor to avoid skin irritation or make the skin susceptible to bacterial infection (11). Natural acidity of the skin ranges from 4 to 6, depending on the skin area and the age of the individual, due to the buffer system in the skin that is able to absorb small quantities of acid or alkali material applied to reduce irritation (27). Our pH findings make both formulations suitable for topical application.…”

Section: Discussionmentioning

confidence: 92%

Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels

et al. 2017

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In order to obtain dermal vehicles of ketorolac tromethamine (KT) for the local treatment of inflammation and restrict undesirable side effects of systemic levels hydrogels (HGs) of poloxamer and carbomer were developed. METHODS:KT poloxamer based HG (KT-P407-HG) and KT carbomer based HG (KT-C940-HG) were elaborated and characterized in terms of swelling, degradation, porosity, rheology, stability, in vitro release, ex vivo permeation and distribution skin layers. Finally, in vivo anti-inflammatory efficacy and skin tolerance were also assessed. RESULTS:HGs were transparent and kept stable after 3 months exhibiting biocompatible near neutral pH values. Rheological patterns fitted to Herschel-Bulkley for KT-C940-HG and Newton for KT-P407-HG due to its low viscosity at 25°C. Rapid release profiles were observed through first order kinetics. Following the surface the highest concentration of KT from C940-HG was found in the epidermis and the stratum corneum for P407-HG. Relevant anti-inflammatory efficacy of KT-P407-HG revealed enough ability to provide sufficient bioavailability KT to reach easily the site of action. The application of developed formulations in volunteers did not induce any visual skin irritation. CONCLUSIONS:KT-P407-HG was proposed as suitable formulation for anti-inflammatory local treatment without theoretical systemic side effect.

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Section: Discussionmentioning

confidence: 92%

Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels

et al. 2017

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“…The combination of chemical sunscreens with melatonin, rutin, lipophilic antioxidants proved their efficacy as sun protection boosters and inhibitors of skin photo-oxidative damage [90,105]. For the conventional synthetic organic filters, many of which are potential endocrine disruptors, the inhibition of their deep penetration in the dermis remains a primary clinical goal.…”

Section: Formulation Of Sun Protective Cosmetics Based On Secondary Pmentioning

confidence: 99%

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Korkina¹,

Kostyuk

Potapovich

et al. 2018

Cosmetics

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Topical sun protective cosmetics (sunscreens, pre-and post-sun) have been intensively developed and produced to protect human skin against solar irradiation-associated damages/pathologies. Unfortunately, routine cosmetics for sun protection containing synthetic organic and/or physical sunscreens could exert adverse effects towards human organisms and bring undesirable ecological changes. Terrestrial and marine plant species, being exposed to sun light for hundreds of millions of years, have evolved two pro-survival strategies: effective protection against/adaptation to its deleterious effects and the use of solar energy for photosynthesis/photo-biochemical reactions. Secondary plant metabolites (SPM) are primary sensors of solar energy and mediators of its use (photo-sensitisers) or neutralisation (photo-protectors). A similar double photo-protective/photo-sensitising system is built in within human skin. Modern development of toxicologically/ecologically safe yet effective sun-protective cosmetics attempts to pre-select photo-stable and non-phototoxic SPMs that provide broad UVA + UVB sunscreen, free radical scavenging and direct antioxidant defence, endogenous antioxidant rescue, induction of antioxidant enzymes (indirect antioxidant defence), and normalisation of metabolic and immune responses to UVA + UVB. Proper formulation of sun protective cosmetics should assure targeted delivery of photo-active SPMs to definite skin layers to invigorate the built in photo-chemical skin barrier.

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“…In the literature, several scientific publications show rheological and optical properties of sunscreen creams containing different and/or mixtures of sunscreen active ingredients 10,[12][13][14][15][16][17][18] . However, the understanding of possible surface interactions between sunscreen constituents that influence the colloidal stability, mechanical and optical properties of sunscreen creams require more detailed studies.…”

Section: Introductionmentioning

confidence: 99%

Study of the colloidal stability and optical properties of sunscreen creams

et al. 2019

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Sunscreen formulations containing inorganic/organic filters or mixture of them were synthesized by oil/water dispersion. The viscosity measurements show that sunscreen formulations are time-dependent non-newtonian fluids. In the CIELab color diagram, the white and/or beige colors presented by formulations do not compromise the aesthetics of the cosmetic product. UV-VIS absorption spectra show that sunscreen creams have high UV shielding ability, mainly the formulations containing inorganic and organic filters mixtures, which provide in vitro SPF and critical wavelength values recommended for UV protection.

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In vivo and in vitro evaluation of the use of a newly developed melatonin loaded emulsion combined with UV filters as a protective agent against skin irradiation

Cited by 40 publications

References 45 publications

Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels

Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Study of the colloidal stability and optical properties of sunscreen creams

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