In vivo and in vitro effects of magnesium sulfate in the cerebrovascular bed of the goat

Perales, Alfredo; Torregrosa, José-Vicente; Salom, Juan B.; Miranda, Francisco Javier; Alabadí, José A.; Monleón, Javier; Alborch, Enrique

doi:10.1016/s0002-9378(12)90795-4

Cited by 8 publications

(12 citation statements)

References 18 publications

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“…However, the Mg values in serum were markedly increased (up to 4 mmol/l) in these studies. This is also true of the vasodilative effect of Mg shown in several vascular systems [1,2,13,19,27]. Animal studies have shown that solutions >5 mmol/l Mg may prevent isolated coronary microvessels of ferrets from Ca 2+ -overloading during hypoxia and preserve vascular function during reoxygenation [19].…”

Section: Discussionmentioning

confidence: 99%

Preventive magnesium supplement reduces ischemia-induced hearing loss and blood viscosity in the guinea pig

Scheibe¹,

Haupt²,

Vlastos

2000

European Archives of Oto-Rhino-Laryngology

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The effect of magnesium (Mg) on ischemia-induced hearing loss was investigated in two groups of adult pigmented guinea pigs of either an optimal or suboptimal (physiologically high or low) Mg status maintained by different diets. Total Mg concentrations of the perilymph, cerebrospinal fluid, blood plasma and red blood cells were found to differ significantly between the two groups, as tested in a previous study. Local vascular impairment was produced by unilateral ferromagnetic thrombosis of cochlear blood vessels. Cochlear blood flow (CBF) and hearing function were measured using laser Doppler flowmetry and auditory brain-stem response audiometry, respectively. Ferromagnetic thrombosis resulted in significant reductions of the mean apical CBF in both experimental groups and of the mean basal CBF in the low Mg group compared to the contralateral ears. In the high Mg group, the basal CBF was not decreased. However, the laser Doppler signals revealed considerable interindividual variations and the differences found between the two experimental groups were not significant. In contrast, the hearing loss in the low Mg group was significantly higher than that in the high Mg group. A correlation was found to exist between the vascular impairment and the hearing threshold shift. In a separate series, we also tested the effect of Mg on hemorheology and found both the blood viscosity and blood viscoelasticity to be significantly lower in the high Mg group than in the low Mg group, depending on the shear rates tested. The present findings show that a preventive oral Mg supplement can significantly reduce the rate of ischemia-induced hearing loss and improve blood viscosity in the guinea pig.

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Section: Discussionmentioning

confidence: 99%

Preventive magnesium supplement reduces ischemia-induced hearing loss and blood viscosity in the guinea pig

Scheibe¹,

Haupt²,

Vlastos

2000

European Archives of Oto-Rhino-Laryngology

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“…In goats, both intravenously and after direct injection into the cerebral circulation, MgSO 4 was associated with increased cerebral perfusion and reduced vascular resistance [57]. Thus, it is possible that pretreatment with MgSO 4 in models of carotid ligation may promote an essentially artifactual improvement in perfusion during hypoxia [36,39,45].…”

Section: Discussionmentioning

confidence: 99%

Magnesium Is Not Consistently Neuroprotective for Perinatal Hypoxia-Ischemia in Term-Equivalent Models in Preclinical Studies: A Systematic Review

et al. 2014

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There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO₄) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but that it has no effect on death or disability. Because of this inconsistency, it remains controversial whether MgSO₄ is clinically neuroprotective and, thus, it is unclear whether it would be appropriate to test MgSO₄ for treatment of encephalopathy in term infants. We therefore systematically reviewed the preclinical evidence for neuroprotection with MgSO₄ before or after hypoxic-ischemic encephalopathy (HIE) in term-equivalent perinatal and adult animals. The outcomes were highly inconsistent between studies. Although there were differences in dose and timing of administration, there was evidence that beneficial effects of MgSO₄ were associated with confounding mild hypothermia and, strikingly, the studies that included rigorous maintenance of environmental temperature or body temperature consistently suggested a lack of effect. On balance, these preclinical studies suggest that peripherally administered MgSO₄ is unlikely to be neuroprotective. Rigorous testing in translational animal models of perinatal HIE is needed before MgSO₄ should be considered in clinical trials for encephalopathy in term infants.

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“…There is evidence to suggest that magnesium (Mg 2+ ) is bene®cial in the treatment of a number of conditions, including pre-eclampsia (Lucas et al, 1995;Eclampsia Trial Collaborative Group, 1995) and acute myocardial infarction (Woods et al, 1992). The mode of action of Mg 2+ in these conditions is not clear, although vasodilator properties of Mg 2+ are well documented both in vitro (Altura & Altura, 1980Altura & Turlapaty, 1981;Kimura et al, 1989;Skajaa et al, 1990;Szabo et al, 1991Szabo et al, , 1992Noguera & D'Ocon, 1993), and in vivo (Seelig et al, 1983;Dipette et al, 1987;Nishio et al, 1989;Chi et al, 1990;Ram et al, 1991;Sipes et al, 1991;Perales et al, 1991;Kemp et al, 1993Kemp et al, , 1994. Woods (1991) suggested that Mg 2+ is a coronary vasodilator, and that some of the bene®cial eect of Mg 2+ in the treatment of acute myocardial infarction may be due to the prevention and relief of coronary vasospasm associated with the condition.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the effects of endothelin‐1 and magnesium sulphate on regional blood flows in conscious rats, by the coloured microsphere reference technique

Kemp

Gardiner

March

et al. 1999

British J Pharmacology

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1 There is evidence to suggest that magnesium (Mg 2+ ) is bene®cial in the treatment of a number of conditions, including pre-eclampsia and acute myocardial infarction. The mode of action of Mg 2+ in these conditions is not clear, although the vasodilator properties of Mg 2+ are well documented both in vitro and in vivo. 2 Previously, we demonstrated that i.v. infusion of magnesium sulphate (MgSO 4 ) alone, or in the presence of vasoconstrictors, caused increases in¯ow and conductance in the common carotid, internal carotid and hindquarters vascular beds, in conscious rats. Therefore, the objective of the present study was to investigate the regional and subregional changes in haemodynamics in response to the vasoconstrictor peptide endothelin-1 (ET-1) and MgSO 4 in more detail, using the coloured microsphere reference technique. 3 Infusion of ET-1 and MgSO 4 had similar e ects on heart rate and mean arterial pressure as in our previous study. Infusion of ET-1 caused a rise in mean arterial pressure and a fall in heart rate, and infusion of MgSO 4 returned mean arterial pressure to control levels with no e ect on heart rate. 4 The responses to MgSO 4 in the presence of ET-1 showed considerable regional heterogeneity with blood¯ow increasing (e.g. skeletal muscle), decreasing (e.g. stomach) or not changing (e.g. kidney). Of particular interest was the ®nding that MgSO 4 caused increases in¯ow in the cerebral and coronary vascular beds. 5 This, and our previous studies, have shown that MgSO 4 can reverse vasoconstriction in a number of vascular beds, and indicate that this compound may have therapeutic bene®t in conditions associated with vasospasm.

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In vivo and in vitro effects of magnesium sulfate in the cerebrovascular bed of the goat

Cited by 8 publications

References 18 publications

Preventive magnesium supplement reduces ischemia-induced hearing loss and blood viscosity in the guinea pig

Preventive magnesium supplement reduces ischemia-induced hearing loss and blood viscosity in the guinea pig

Magnesium Is Not Consistently Neuroprotective for Perinatal Hypoxia-Ischemia in Term-Equivalent Models in Preclinical Studies: A Systematic Review

Assessment of the effects of endothelin‐1 and magnesium sulphate on regional blood flows in conscious rats, by the coloured microsphere reference technique

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