In vivo and In vitro Model for Evaluation of Anti-microbial activity: A Review

Abstract

The rates of infectious diseases have significantly increased in recent years. So need for production, evaluation and standardization of new antimicrobial agents has also increased. The major problem of resistance towards antibacterial, antiviral, etc drugs is also posing a great threat to human beings as many bacteria, viruses and fungi have become resistant to commonly used drugs. However, microbes are also useful for us in our basic physiological functions, for example: digestion, so we also need to make sure the new molecules of antimicrobials do not cause harm to our natural microbial flora. In this review, we have tried to assemble some In-Vivo and In-vitro Model for evaluating Antimicrobial agents. Classifications of antibacterials, antivirals and antifungals have been displayed in an easy way. The use of herbal drugs is displayed in a tabular manner and finally the evaluation parameters have been discussed.