In vivo and in vitro genotoxicity assessment of 2-methylisoborneol, causal agent of earthy–musty taste and odor in water

Burgos, Leonel; Lehmann, Maurı́cio; Andrade, Heloı́sa Helena Rodrigues de; Abreu, Bianca Regina Ribas de; Souza, Ana Paula de; Juliano, Viviane Berwanger; Dihl, Rafael Rodrigues

doi:10.1016/j.ecoenv.2013.10.022

Cited by 16 publications

(7 citation statements)

References 32 publications

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“…Investigations showed that 2-methylisoborneol induced neither mutagenesis nor recombinogenesis in Drosophila melanogaster and was not genotoxic in the CBMN-cytome assay using Chinese hamster ovary cells. Positive results were obtained in the comet assay only when 2-methylisoborneol was used at the highest concentration [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of In Vivo and In Vitro Genotoxicity of Glibenclamide in Eukaryotic Cells

et al. 2015

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Glibenclamide is an oral hypoglycemic drug commonly prescribed for the treatment of type 2 diabetes mellitus, whose anti-tumor activity has been recently described in several human cancer cells. The mutagenic potential of such an antidiabetic drug and its recombinogenic activity in eukaryotic cells were evaluated, the latter for the first time. The mutagenic potential of glibenclamide in therapeutically plasma (0.6 μM) and higher concentrations (10 μM, 100 μM, 240 μM and 480 μM) was assessed by the in vitro mammalian cell micronucleus test in human lymphocytes. Since the loss of heterozygosity arising from allelic recombination is an important biologically significant consequence of oxidative damage, the glibenclamide recombinogenic activity at 1 μM, 10 μM and 100 μM concentrations was evaluated by the in vivo homozygotization assay. Glibenclamide failed to alter the frequency of micronuclei between 0.6 μM and 480 μM concentrations and the cytokinesis block proliferation index between 0.6 μM and 240 μM concentrations. On the other hand, glibenclamide changed the cell-proliferation kinetics when used at 480 μM. In the homozygotization assay, the homozygotization indices for the analyzed markers were lower than 2.0 and demonstrated the lack of recombinogenic activity of glibenclamide. Data in the current study demonstrate that glibenclamide, in current experimental conditions, is devoid of significant genotoxic effects. This fact encourages further investigations on the use of this antidiabetic agent as a chemotherapeutic drug.

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Section: Discussionmentioning

confidence: 99%

Assessment of In Vivo and In Vitro Genotoxicity of Glibenclamide in Eukaryotic Cells

et al. 2015

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“…Cyanobacteria often produce foul taste and odor compounds such as geosmin and 2-methylisoborneol during their life cycle, senescence and decomposition [ 9 , 10 ]. These taste and odor compounds are not believed to present major health risks, but their potential toxicity has been little studied [ 11 ]. Importantly, these odorous compounds can indicate the need to prevent human and animal exposure to water that may also contain potentially lethal cyanotoxins [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

One Health and Cyanobacteria in Freshwater Systems: Animal Illnesses and Deaths Are Sentinel Events for Human Health Risks

Hilborn

Beasley

2015

Toxins

124

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Harmful cyanobacterial blooms have adversely impacted human and animal health for thousands of years. Recently, the health impacts of harmful cyanobacteria blooms are becoming more frequently detected and reported. However, reports of human and animal illnesses or deaths associated with harmful cyanobacteria blooms tend to be investigated and reported separately. Consequently, professionals working in human or in animal health do not always communicate findings related to these events with one another. Using the One Health concept of integration and collaboration among health disciplines, we systematically review the existing literature to discover where harmful cyanobacteria-associated animal illnesses and deaths have served as sentinel events to warn of potential human health risks. We find that illnesses or deaths among livestock, dogs and fish are all potentially useful as sentinel events for the presence of harmful cyanobacteria that may impact human health. We also describe ways to enhance the value of reports of cyanobacteria-associated illnesses and deaths in animals to protect human health. Efficient monitoring of environmental and animal health in a One Health collaborative framework can provide vital warnings of cyanobacteria-associated human health risks.

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“…Most of selected VOCs can pose significant risk to biological systems and human health with their toxic, carcinogenic, and/or mutagenic properties at very low concentrations (Liu and Zhou, 2011;Ma et al, 2014). Other compounds, such as carbonyl compounds blamed for odor problems (Dą browska and Nawrocki, 2013), some biogenic VOCs 2-methylisoborneol (MIB) and goesmin have not been associated with immediate health effects yet they can have a profound effect on consumer acceptance due to their extremely low odor threshold concentrations (OTCs) (Burgos et al, 2014;Robertson et al, 2006). Accordingly, it is essential to environmental managers to understand hazards of VOCs in source water, besides the current pollution level.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous assessments of occurrence, ecological, human health, and organoleptic hazards for 77 VOCs in typical drinking water sources from 5 major river basins, China

Chen

Luo

Wang

et al. 2015

Environmental Pollution

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Ecological risk assessment Human health risk assessment Taste and odor a b s t r a c tOwing to the growing public awareness on the safety and aesthetics in water sources, more attention has been given to the adverse effects of volatile organic compounds (VOCs) on aquatic organisms and human beings. In this study, 77 target VOCs (including 54 common VOCs, 13 carbonyl compounds, and 10 taste and odor compounds) were detected in typical drinking water sources from 5 major river basins (the Yangtze, the Huaihe, the Yellow, the Haihe and the Liaohe River basins) and their occurrences were characterized. The ecological, human health, and olfactory assessments were performed to assess the major hazards in source water. The investigation showed that there existed potential ecological risks (1.30 Â 10 RQ total s 8.99 Â 10) but little human health risks (6.84 Â 10 À7 RQ total s 4.24 Â 10 À4 ) by VOCs, while that odor problems occurred extensively. The priority contaminants in drinking water sources of China were also listed based on the present assessment criteria.

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In vivo and in vitro genotoxicity assessment of 2-methylisoborneol, causal agent of earthy–musty taste and odor in water

Cited by 16 publications

References 32 publications

Assessment of In Vivo and In Vitro Genotoxicity of Glibenclamide in Eukaryotic Cells

Assessment of In Vivo and In Vitro Genotoxicity of Glibenclamide in Eukaryotic Cells

One Health and Cyanobacteria in Freshwater Systems: Animal Illnesses and Deaths Are Sentinel Events for Human Health Risks

Simultaneous assessments of occurrence, ecological, human health, and organoleptic hazards for 77 VOCs in typical drinking water sources from 5 major river basins, China

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