In vivo and in vitro diagnostics using Full Field Optical Coherence Tomography

Development of an intelligent full‐field polarization sensitive optical coherence tomography for breast cancer classification

“…It is a lowcoherence interferometry-based technology that enables high-speed, non-contact, non-invasive three-dimensional imaging with a spatial resolution of less than 15 μm in the axial and lateral directions, and milli-metre scale imaging depth [21][22][23]. Though, needle-based OCT devices have been used for both breast margin assessment and biopsy evaluation [24][25][26][27][28], still early diagnosis poses a challenging task. Cancer related tissue abnormalities like angiogenesis, hypermetabolism and invasion of adjacent healthy tissues exhibit the optical signatures such as polarization, dispersion and absorption, therefore detecting them can lead to early diagnosis [29,30].…”

“…Though, conventional PS-OCT based on single-pointer raster scanning has been used to distinguish between benign fibroadenoma and IDC [46], but this system requires extensive scanning, introduces mechanical jitter, reduces reproducibility due to motion artefacts and is limited by the field of view. Therefore, a full-field PS-OCT (FF-PS-OCT) system has been employed as it eliminates the need of pointer raster scanning by replacing the photodetector with a 2D camera, which in a single shot records the complete enface image (orthogonal to the optical system) [27].…”