In vivo and in vitro effects of a new hypoglycemic agent, 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304) on glucose metabolism in guinea pigs

Kühnle, H.F.; Schmidt, Felix; Deaciuc, Ion V.

doi:10.1016/0006-2952(84)90410-6

Cited by 11 publications

(5 citation statements)

References 24 publications

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“…Diabetes is an endocrine disorder disease that involves multiple organs . Generally, hypoglycaemic agents achieved their effects via the promotion of insulin secretion and the inhibition of GN . For instance, aside from its hypoglycaemic effects, chlorella can strengthen the functions of external insulin .…”

Section: Resultsmentioning

confidence: 99%

“…28 Generally, hypoglycaemic agents achieved their effects via the promotion of insulin secretion and the inhibition of GN. 29 For instance, aside from its hypoglycaemic effects, chlorella can strengthen the functions of external insulin. 30 It was reported that the level of -carotene was inversely associated with the blood glucose concentration, and its hypoglycaemic function might be achieved via its antioxidant activity in vivo.…”

Section: Anti-diabetic Effects Of the -Carotene Extract In Stz-inducementioning

confidence: 99%

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Optimised extraction ofβ‐carotene fromSpirulina platensisand hypoglycaemic effect in streptozotocin‐induced diabetic mice

Fang

Zheng

et al. 2015

J Sci Food Agric

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Section: Resultsmentioning

confidence: 99%

Section: Anti-diabetic Effects Of the -Carotene Extract In Stz-inducementioning

confidence: 99%

Optimised extraction ofβ‐carotene fromSpirulina platensisand hypoglycaemic effect in streptozotocin‐induced diabetic mice

Fang

Zheng

et al. 2015

J Sci Food Agric

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“…Studies on the mode ment of diabetes, such substances facilitate studies of action revealed that 2-(3-methyl-cinnamyl-hydraon the interrelationship betwen metabolic pathways, zpno)-prppionate inhibits gluconeogenesis in guinea provided that their mode of action is known. pig liver (7,8). Furthermore in the rat and in the guinea pig an increase in the concentration of free .…”

mentioning

confidence: 94%

Inhibition of Mitochondrial Carnitine Acylcarnitine Translocase-Mediated Uptake of Carnitine by 2-(3-Methyl-cinnamyl-hydrazono)-propionate. Hydrazonopropionic Acids, a New Class of Hypoglycaemic Substances, VI

Beneking

Oellerich²,

Haeckel³

et al. 1987

Clinical Chemistry and Laboratory Medicine

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The rate of mitoehondrial carnitine-carnitine exchange mediated by carnitine acylcarnitine translocase was measured by föllowing the uptake of L-[methyl-14 C]carnitine. It was demonstrated that the hypoglycaemic compound 2-(3^methyKcinnamyl-hydrazono)-propionate causes a concentration-dependent decrease in the rate of the translocase-mediated transport of carnitine in guinea pig liver mitochondria. Apparent initial infhix rates were decreased by 20% at 0.3 mmol/1 2-(3-methyl-cinnamyl-hydrazono)-propionate, 38% at 0.5 mmol/1, and 75% at 2.0 mmol/1 of this compound. This finding may explain the previously observed inhibitory effects öf this substance on long^chain fatty acid oxidation, ketone body production and gluconeogenesis. ™ "Among these hydrazpnes, 2-(3^methyl-cinnamyl-hyHydrazpnes of pyruvate exert a powerful hyppgly-drazpnp)-propionate is a powerful hypoglycaemic agcaemic effect in varioüs labprätpry aiiimals (1-6). ent, the metabolic effects of which have already been In addition to theif potential usefulness for the treat-studied in considerable detail. Studies on the mode ment of diabetes, such substances facilitate studies of action revealed that 2-(3-methyl-cinnamyl-hydraon the interrelationship betwen metabolic pathways, zpno)-prppionate inhibits gluconeogenesis in guinea provided that their mode of action is known. pig liver (7,8). Furthermore in the rat and in the guinea pig an increase in the concentration of free .fatty acids in the plasma and a decrease in blood 0 Preliminary results of this study were presented at the third ketone body concentration was observed, which meetingoftbeGermanAsspciation for the Studyof the Liver pointed to an Inhibition of long-chain fatty acid oxm Hannover 1987 (abstract: Z. Gastroenterologie (1987) 25. idation (5)e It has been suggested that this Inhibition 2 ) For previous publications see I.e. (3-5), (8), (25). by 2-(3-methyl-cinnamyl-hydrazono)-propionate oc-

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“…The relative contributions of increased hepatic glucose production and peripheral insulin resistance to the establishment and maintenance of the hyperglycemic state have not been established. However, available evidence suggests either inhibition of hepatic glucose production (1)(2)(3) or enhancement of insulin-stimulated glucose disposal (4-6) will decrease blood glucose levels and ameliorate the diabetic state. There has been considerable interest in the potential utility of fatty acid oxidation inhibitors, particularly the carnitine palmitoyltransferase (CPT) inhibitors 2-tetradecylglycidic acid (TDGA) and Etomoxir, for the treatment of NIDDM patients (7)(8)(9).…”

mentioning

confidence: 99%

Inhibition of Hepatic Glucose Production by SDZ 51641

Young¹,

Ho²,

Bell³

et al. 1990

Diabetes

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The new oral hypoglycemic agent SDZ 51641 was evaluated in nondiabetic rats and a rat model of human non-insulin-dependent diabetes mellitus. Diabetes was induced with a single injection of 37.5 mg/kg streptozocin, and the rats exhibited hyperglycemia in the fed state with normal insulin levels. Treatment of nondiabetic animals with 100 mg/kg SDZ 51641 given orally significantly decreased serum glucose and ketone levels within 4 h without affecting insulin levels. Nonesterified fatty acids increased more than twofold during the same period. Its effect on ketone and fatty acid levels suggests that SDZ 51641 acts as an inhibitor of fatty acid oxidation. Diabetic rats treated with SDZ 51641 exhibited a significant acute hypoglycemic response, which was more pronounced after 3 days of treatment. The compound also significantly decreased serum cholesterol and triglyceride levels 27 and 53%, respectively. When endogenous hepatic glucose production was assessed in nondiabetic and diabetic animals via continuous infusion of [3-3H]glucose, we found that hepatic glucose production was elevated 43% in diabetic compared with control animals. When diabetic rats were treated with 100 mg/kg SDZ 51641, hepatic glucose production decreased to normal levels within 6 h. Hyperinsulinemic-euglycemic clamp studies indicated that SDZ 51641 had no effect on insulin-stimulated glucose utilization. Measurement of [1-14C]oleate oxidation in isolated hepatocytes demonstrated that SDZ 51641 inhibited long-chain fatty acid oxidation in a concentration-dependent manner. The compound was ineffective at inhibiting long-chain fatty acid oxidation in epitrochlearis or soleus muscles.(ABSTRACT TRUNCATED AT 250 WORDS)

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In vivo and in vitro effects of a new hypoglycemic agent, 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304) on glucose metabolism in guinea pigs

Cited by 11 publications

References 24 publications

Optimised extraction ofβ‐carotene fromSpirulina platensisand hypoglycaemic effect in streptozotocin‐induced diabetic mice

Optimised extraction ofβ‐carotene fromSpirulina platensisand hypoglycaemic effect in streptozotocin‐induced diabetic mice

Inhibition of Mitochondrial Carnitine Acylcarnitine Translocase-Mediated Uptake of Carnitine by 2-(3-Methyl-cinnamyl-hydrazono)-propionate. Hydrazonopropionic Acids, a New Class of Hypoglycaemic Substances, VI

Inhibition of Hepatic Glucose Production by SDZ 51641

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