In vivo and in vitro studies of efficient mephedrone adsorption over zirconium-based metal-organic frameworks corroborated by DFT+D modeling

Crystal Clear: Metal–Organic Frameworks Pioneering the Path to Future Drug Detox

“…The presence of similar functional groups in both MOFs and considered drugs may overlap and the successful band assignment may be challenging. It is also worth mentioning that in the literature data methods such as the Surface Enhanced Raman Spectroscopy (SERS) or the Fourier Transform Infrared Spectroscopy (FTIR) are successfully applied to fast and efficient illicit drug detection , even at very low concentrations, those methods are efficient when considering illicit drug in neat state. In our case, low-concentration illicit drugs are adsorbed in the MOF structures, and enhancing Raman signals by SERS would result in a simultaneous increase in the bands of both the MOF and the drug of abuse.…”

“…Drug of Abuse Adsorption Studies. The adsorption efficiency of selected drugs of abuse, including AMP, mAMP, MDMA, and COC, was determined by the procedure previously reported for mephedrone, 31 previously activated MOF samples to 2 mL of 500 μM drug aqueous solutions (AMP, mAMP, MDMA, or COC) under constant temperature conditions (25 °C). The concentrations of drugs of abuse were measured at specific time intervals by collecting 0.1 mL samples.…”

“…Although in this study the application of selected MOFs for the removal of drugs of abuse during acute overdoses, their application for the removal of drugs of abuse from the aqueous solutions in other applications cannot be excluded as previously reported elsewhere. 31 In Vitro. The in vitro experiments were performed to check the safety and effectiveness of the studied MOF in cellular models of neurotoxicity and cardiotoxicity, as the psychoactive substances seem to exert the most potent effects on those cells (organs).…”

“…In the case of the adsorption efficiency of MOFs, their potential use for pharmaceutical water purification has also been proven. − Additionally, the use of MOFs in the adsorption of hippuric acid and 3-indoleacetic acid has been reported to imitate an artificial kidney . Likewise, mephedrone sorption by MOF networks has been described . High sorption capacity is yet another advantageous property.…”

Influence of Thermal and Chemical Treatment on Biosorbent from Rice Husk and Its Application in Removal of Resorcinol from Industrial Wastewater

“…The physical adsorption technique is often thought to be the best, most viable, and frequently utilized strategy, which requires minimal effort, for the expulsion of phenolic compounds. Adsorption is a well-known separation process [26,27], which has a multitude of different applications, such as wastewater treatment, water desalination [28], pressure swing adsorption for the separation of gases [29,30], carbon capture and use [31], or production of cold in adsorption chillers [27,32], just to name a few. Adsorption has been found to be superior to other techniques for water reuse because of its low initial cost, flexibility and simplicity of design, ease of operation, and insensitivity to toxic pollutants [33].…”