In Vivo and In Vitro Feasibility Studies of Intraocular Use of Polyethylene Glycol–Based Synthetic Sealant to Close Retinal Breaks in Porcine and Rabbit Eyes

Hoshi, Sujin; Okamoto, Fumiki; Arai, Mikki; Hirose, Tatsuo; Sugiura, Yoshimi; Kaji, Yuichi; Oshika, Tetsuro

doi:10.1167/iovs.14-15349

Cited by 27 publications

(27 citation statements)

References 19 publications

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“…Upon exposure to xenon light (450-500 nm) for 40-60 s, the prepolymer solution formed a solid, crosslinked hydrogel. The adhesive remained attached for 24 h despite a forceful squirt of balanced salt solution, showed little inflammatory reaction in the eyes during 28 days of follow up, and the electroretinography also did not show any abnormality or inflammation [81]. In addition, the authors also conducted an in vivo study to investigate the application of this photo-curable PEG-based sealant for the closure of sutureless sclerotomies (surgical incision of the sclera) in microincisional vitrectomy surgery (MIVS) using a Dutch pigmented rabbit eye model (Fig.…”

Section: Peg-based Adhesivesmentioning

confidence: 91%

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Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications, including suture breakage, inflammation, secondary neovascularization, erosion to the surface and secondary infection, and astigmatism; for example, more than half of post-corneal transplant infections are due to suture related complications. Tissue adhesives provide promising substitutes for sutures in ophthalmic surgery. Ocular adhesives are not only intended to address the shortcomings of sutures, but also designed to be easy to use, and can potentially minimize post-operative complications. Herein, recent progress in the design, synthesis, and application of ocular adhesives, along with their advantages, limitations, and potential are discussed. This review covers two main classes of ocular adhesives: (1) synthetic adhesives based on cyanoacrylates, polyethylene glycol (PEG), and other synthetic polymers, and (2) adhesives based on naturally derived polymers, such as proteins and polysaccharides. In addition, different technologies to cover and protect ocular wounds such as contact bandage lenses, contact lenses coupled with novel technologies, and decellularized corneas are discussed. Continued advances in this area can help improve both patient satisfaction and clinical outcomes.

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Section: Peg-based Adhesivesmentioning

confidence: 91%

mentioning

confidence: 99%

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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“…Hoshi et al demonstrated that FocalSeal PEG (Genzyme Corporation) successfully sealed in vitro porcine retinal tears 11. Hoshi et al also used PEG to seal sclerotomies post vitrectomy surgery in rabbit eyes 85.…”

Section: Retina Surgerymentioning

confidence: 99%

Surgical adhesives in ophthalmology: history and current trends

et al. 2018

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Tissue adhesives are gaining popularity in ophthalmology, as they could potentially reduce the complications associated with current surgical methods. An ideal tissue adhesive should have superior tensile strength, be non-toxic and anti-inflammatory, improve efficiency and be cost-effective. Both synthetic and biological glues are available. The primary synthetic glues include cyanoacrylate and the recently introduced polyethylene glycol (PEG) derivatives, while most biological glues are composed of fibrin. Cyanoacrylate has a high tensile strength, but rapidly polymerises upon contact with any fluid and has been associated with histotoxicity. Fibrin induces less toxic and inflammatory reactions, and its polymerisation time can be controlled. Tensile strength studies have shown that fibrin is not as strong as cyanoacrylate. While more research is needed, PEG variants currently appear to have the most promise. These glues are non-toxic, strong and time-effective. Through MEDLINE and internet searches, this paper presents a systematic review of the current applications of surgical adhesives to corneal, glaucoma, retinal, cataract and strabismus surgeries. Our review suggests that surgical adhesives have promise to reduce problems in current ophthalmic surgical procedures.

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“…FocalSeal was used with 100% success as a supplement to sutures or staples to repair air leaks after pulmonary resection in pigs [77]. It was also used successfully to repair retinal breaks [78].…”

Section: Synthetic Hydrogel Sealants 2251 Photocrosslinkable Polymentioning

confidence: 99%

Adhesive Materials for Biomedical Applications

Vernengo¹

2016

Adhesives - Applications and Properties

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Recently, polymeric bioadhesives have become known as promising alternatives to sutures, staples, and wires. Traditional wound closure techniques are time-consuming to apply and cause additional tissue damage. In instances of large-scale hemorrhage or minimally invasive laparoscopic surgery, sutures are impractical to apply. Alternatively, newly developed bioadhesives are polymers that can be dripped or sprayed over superficial or internal injuries, solidifying in situ to form a seal that apposes tissue or arrests bleeding over large areas. This review will outline the main categories of polymers that have been investigated for these applications. The chemistry, mechanisms of adhesion, and advantages and limitations of each category will be described. In addition, needs for next-generation adhesives in tissue engineering will be discussed. For the repair of certain load-bearing areas of the body, such as cartilage and the intervertebral disc, scaffold adhesion is necessary for anchoring the scaffold in place and providing adequate transmission of forces. Researchers continue developing new formulations that exhibit improved biocompatibility, strength, elasticity, and degradability. These advances promise to improve clinical outcomes by enhancing bleeding control and wound healing. In the long term, bioadhesives will play an important role in making orthopedic and musculoskeletal tissue engineering clinically feasible.

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In Vivo and In Vitro Feasibility Studies of Intraocular Use of Polyethylene Glycol–Based Synthetic Sealant to Close Retinal Breaks in Porcine and Rabbit Eyes

Abstract: Polyethylene glycol-based synthetic sealant appeared to effectively seal retinal breaks and was not toxic to the eye.

Cited by 27 publications

References 19 publications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Surgical adhesives in ophthalmology: history and current trends

Adhesive Materials for Biomedical Applications

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