In vivo and in silico anti-inflammatory properties of the sesquiterpene valencene

Dantas, Lindaiane Bezerra Rodrigues; Alcântara, Isabel Sousa; Júnior, Cícero Pedro S.; Oliveira, Maria Rayane Correia de; Martins, Anita O.B.P.B.; Dantas, Ticiano M.; Ribeiro-Filho, Jaime; Coutinho, Henrique Douglas Melo; Passos, Fabíolla Rocha Santos; Quintans‐Júnior, Lucindo José; Almeida, Jackson R.G.S.; Cruz-Martins, Natália; Kim, Bonglee; Menezes, Irwin Rose Alencar de

doi:10.1016/j.biopha.2022.113478

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…They pointed out that the administration of valencene to mice suppressed paw edema formation, reduced albumin extravasation and leukocyte recruitment, as well as decreased the levels of myeloperoxidase (MPO), IL-1β, and TNF-α. Valencene was observed to have favorable energy to interact with the cyclooxygenase enzyme (COX-2) and the histamine 1 (H1) receptor via the in silico analysis . Furthermore, valencene is reported to serve as a novel substance for treating inflammatory skin disorders such as atopic dermatitis.…”

Section: Biological Propertiesmentioning

confidence: 99%

“…Valencene was observed to have favorable energy to interact with the cyclooxygenase enzyme (COX-2) and the histamine 1 (H1) receptor via the in silico analysis. 133 Furthermore, valencene is reported to serve as a novel substance for treating inflammatory skin disorders such as atopic dermatitis. Previous research discovered that valencene could notably ameliorate atopic dermatitis symptoms and itching behavior in 1-chloro-2,4-dinitrobenzene (DNCB)-sensitized mice.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Zhang

Chen

et al. 2022

J. Agric. Food Chem.

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Valencene and nootkatone, two sesquiterpenes, extracted from natural sources, have great market potential with diverse applications. This paper aims to comprehensively review the recent advances in valencene and nootkatone, including source, production, physicochemical and biological properties, safety and pharmacokinetics evaluation, potential uses, and their industrial applications as well as future research directions. Microbial biosynthesis offers a promising alternative approach for sustainable production of valencene and nootkatone. Both compounds exert various beneficial activities, including antimicrobial, insecticidal, antioxidant, anti-inflammatory, anticancer, cardioprotective, neuroprotective, hepatoprotective, and nephroprotective and other activities. However, most of the studies are performed in animals and in vitro, making it difficult to give a conclusive description about their health benefits and extend their application. Hence, more attention should be paid to in vivo and long-term clinical studies in the future. Moreover, valencene and nootkatone are considered safe for consumption and show great promise in the applications of food, cosmetic, pharmaceutical, chemical, and agricultural industries.

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Section: Biological Propertiesmentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Zhang

Chen

et al. 2022

J. Agric. Food Chem.

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“…Mice were randomly divided into 5 groups (n = 8): ESO-L (20 mg/kg), ESO-M (40 mg/kg), ESO-H (80 mg/ kg), positive control indomethacin (25 mg/kg), [35] and model (vehicle, water) group. ESO and indomethacin were administrated intragastrically for 1.5 h before the intraperitoneal injection of 0.8 % acetic acid (10 mL/ kg).…”

Section: Acetic Acid-indued Writhing Testmentioning

confidence: 99%

The Ethanol Extract of Syringa oblata Heartwood, a Mongolian Folk Medicine Containing Major Lignans, Exerts Analgesic and Sedative Effects on Mice

Chai

Tai

et al. 2022

Chemistry & Biodiversity

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The heartwood of Syringa oblata Lindl. (SO) is one of Mongolian folk medicines to treat insomnia and pain, while its pharmacological evaluation and underlying mechanism remain unclear. In this study, the sedative effect of ethanol extract of SO (ESO) was evaluated with the locomotor activity test and the threshold dose of pentobarbital sodium-induced sleep test in mice, and the hot plate test, acetic acid-induced writhing test, and formalin test in mice were used to evaluate its analgesic effect. The underlying mechanism of ESO analgesia was explored by RT-PCR and western blot analysis, which is associated with the regulation of the NF-кB signaling pathway. Besides, the main constituents of ESO were characterized by LC/MS data analysis and comparison with isolated pure compounds. The current findings brought evidence for clinical application and further pharmacological and phytochemical studies on SO.

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“…Valencene is a natural sesquiterpene, synthesized and accumulated as a secondary metabolite in fruits of various citrus species, such as Cyperus rotundus (Dantas et al, 2022). Due to its unique odor and bioactivity, valencene has been extensively used in food, beverages, perfumes, and cosmetics industries for flavoring and fragrance purposes (Frohwitter et al, 2014; Ouyang et al, 2019; Sharon‐Asa et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Conversion of carbon dioxide into valencene and other sesquiterpenes with metabolic engineered Synechocystis sp. PCC 6803 cell factories

Sun

et al. 2023

GCB Bioenergy

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Valencene is a natural sesquiterpene with desirable bioactivity and aroma, making it a valuable ingredient in the food and cosmetics industries. Traditionally, valencene was extracted from the citrus fruits, and its applications were restricted by the low concentrations in natural sources and high costs for extraction. Photosynthetic biomanufacturing represents a promising route for efficient and stable production of valencene, while cyanobacteria have been considered one of the most promising platforms regarding biotechnological routes for the direct conversion of CO2. In this work, we engineered Synechocystis sp. PCC 6803 to synthesize valencene. By introducing a heterologous valencene synthase and modifying the native MEP pathway, we obtained an efficient cyanobacterial cell factory that produced 154 mg/L valencene during a semi‐continual cultivation, with an average productivity of 4.3 mg/L/day, and the cell factory exhibited robust growth and production in non‐sterilized conditions. We also achieved the production of other sesquiterpenes including bisabolene, amorpha‐4,11‐diene, farnesene, and nerolidol by engineered cyanobacteria with enhanced MEP pathway flux, showing promising potentials as a universal chassis.

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In vivo and in silico anti-inflammatory properties of the sesquiterpene valencene

Cited by 9 publications

References 31 publications

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

The Ethanol Extract of Syringa oblata Heartwood, a Mongolian Folk Medicine Containing Major Lignans, Exerts Analgesic and Sedative Effects on Mice

Conversion of carbon dioxide into valencene and other sesquiterpenes with metabolic engineered Synechocystis sp. PCC 6803 cell factories

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