In vivo and in silico monitoring bone regeneration during distraction osteogenesis of the mouse femur

Fu, Ruisen; Bertrand, David; Wang, Jianbo; Kavaseri, Kyle; Feng, Yixiang; Du, Tianming; Liu, Youjun; Willie, Bettina M.; Yang, Haisheng

doi:10.1016/j.cmpb.2022.106679

Cited by 5 publications

(1 citation statement)

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“…The most common and burdensome fractures are lower leg fractures of the patella, tibia or fibula, or ankle [ 5 ]. Fracture healing is the process of reconstructing bone and restoring its biological and biomechanical functions [ 6 , 7 ]. As one of the common surgical treatments, internal fixation using screws, pins, plates, etc., provides mechanical stability for a fractured bone, allowing weight bearing, early use of the limb, and bone healing [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation

Liu

Qiao

et al. 2022

JFB

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Traditional inert materials used in internal fixation have caused many complications and generally require removal with secondary surgeries. Biodegradable materials, such as magnesium (Mg)-, iron (Fe)- and zinc (Zn)-based alloys, open up a new pathway to address those issues. During the last decades, Mg-based alloys have attracted much attention by researchers. However, the issues with an over-fast degradation rate and release of hydrogen still need to be overcome. Zn alloys have comparable mechanical properties with traditional metal materials, e.g., titanium (Ti), and have a moderate degradation rate, potentially serving as a good candidate for internal fixation materials, especially at load-bearing sites of the skeleton. Emerging Zn-based alloys and composites have been developed in recent years and in vitro and in vivo studies have been performed to explore their biodegradability, mechanical property, and biocompatibility in order to move towards the ultimate goal of clinical application in fracture fixation. This article seeks to offer a review of related research progress on Zn-based biodegradable materials, which may provide a useful reference for future studies on Zn-based biodegradable materials targeting applications in orthopedic internal fixation.

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