In Vivo Analysis of Vectors Involved in Pupil Constriction in Chinese Subjects with Angle Closure

Zheng, Ce; Cheung, Carol Y.; Aung, Tin; Narayanaswamy, Arun; Ong, Sim Heng; Friedman, David S.; Allen, John C.; Baskaran, Mani; Chew, Paul; Perera, Shamira A.

doi:10.1167/iovs.12-10415

Cited by 23 publications

(18 citation statements)

References 20 publications

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“…[7][8][9][10][11][12][13]33,52,54,55 We have demonstrated that eAS-OCT is capable of evaluating the angle configuration and providing quantitative assessments of all these parameters using one device. Recent studies indicate that several important factors may be associated with the angle closure, such as ACD, LVa, LT, iris thickness, iris curvature, and iris dynamics.…”

Section: Discussionmentioning

confidence: 95%

Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

Johnstone

Wang

2014

J. Biomed. Opt.

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We demonstrate an extended-imaging-range anterior-segment optical coherence tomography (eAS-OCT) system for the biometric assessment of full AS in human eye. This newly developed eAS-OCT operating at 1340-nm wavelength band is simultaneously capable of an imaging speed of 120 kHz A-line scan rate, an axial resolution of 7.2 μm, and an extended imaging range of up to 16 mm in air. Imaging results from three healthy subjects and one subject with a narrow-angle demonstrate the instrument's utility. With this system, it can provide anatomical dimensions of AS, including central corneal thickness, anterior chamber width, anterior chamber depth, crystalline lens vault, crystalline lens thickness, angle opening distance (AOD500/AOD750), and the area described by the trabecular-iris space (TISA500/TISA750) at 500/750 μm. We also use eAS-OCT to image and quantify dynamic functional changes of the AS in response to a light stimulus that induces physiological pupillary changes as well as accommodative efforts that induce lens changes. The results show that the described eAS-OCT is able to provide full anatomical biometry for AS and is useful for the studies where the dynamic response of AS compartment to certain stimulus is required.

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Section: Discussionmentioning

confidence: 95%

Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

Johnstone

Wang

2014

J. Biomed. Opt.

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“…Another investigation found that in Chinese persons with PAC/PACG compared with healthy Chinese subjects, the iris of AC eyes stretched less and developed a more convex configuration as the pupil constricted. 51 Cheung et al 52 found that nonglaucomatous eyes with narrow angles more often retain a bowed forward configuration on pupil enlargement in the dark. Dynamic change in parameters like lens vault might provide new diagnostic information, and the size of the pupil must be taken into account in such measurements.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Dynamic Changes in Anterior Ocular Structures Examined With Anterior Segment Optical Coherence Tomography in a Cohort of Various Origins

Seager¹,

Jefferys²,

Quigley³

2014

Invest. Ophthalmol. Vis. Sci.

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“…Several clinic-based studies have demonstrated that the decrease in iris volume after pupil dilation was less in patients with PACG than normal patients or those with primary open-angle glaucoma (POAG). [25][26][27] A population-based cross-sectional study of rural Chinese persons has shown that the decrease in Iarea and iris volume after physiological and pharmacological dilation was significantly less in PACS than normal eyes. 12,13 Additionally, Seager et al 28 found that Iarea was related to age, race, disease diagnosis and Iarea loss per millimetre of pupil dilation.…”

Section: Discussionmentioning

confidence: 99%

Five-year changes in anterior segment parameters in an older population in urban southern China: the Liwan Eye Study

Jiang

Wang

et al. 2019

Br J Ophthalmol

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PurposeTo investigate the 5-year changes in static and dynamic anterior segment optical coherence tomography (AS-OCT) parameters and their predictors.MethodsThis was a prospective, population-based cohort study of people aged 50 years and older residing in the Liwan District, Guangzhou, China. Standardised AS-OCT scans were performed in November 2008 and November 2013 under dark and light conditions. Customised software was used to analyse horizontal AS-OCT images. Parameters in dark and measurements of light-to-dark changes were used for analyses.ResultsA total of 186 (71.8%) subjects underwent AS-OCT twice, 5 years apart and were included for analyses. The mean age in 2008 was 64.7±7.0 years, and 60.2% were women. The anterior chamber width (ACW) decreased from 11.74±0.44 mm in 2008 to 11.60±0.37 mm in 2013 (p=0.001). There was a trend towards a decrease in dynamic capacity (light-to-dark changes) in the anterior segment, with decreased iris thickness at 750 µm (ΔIT750), ΔACW, Δ anterior chamber area (ACA) and Δ pupil diameter at 5 years (all p<0.05). After adjusting for age and sex, the following baseline parameters were associated with a greater decrease rate in trabecular iris space area at 500 µm (TISA500) at 5 years: TISA500, IT750 and ACA in dark (p<0.001 for all).ConclusionsAnterior chamber angle width decreased and the amount of light-to-dark changes declined during 5-year follow-up. Subjects with greater height, wider angle width and thicker iris at baseline have greater angle narrowing at follow-up.

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In Vivo Analysis of Vectors Involved in Pupil Constriction in Chinese Subjects with Angle Closure

Cited by 23 publications

References 20 publications

Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

Comparison of Dynamic Changes in Anterior Ocular Structures Examined With Anterior Segment Optical Coherence Tomography in a Cohort of Various Origins

Five-year changes in anterior segment parameters in an older population in urban southern China: the Liwan Eye Study

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