In Vivo Analysis of a Biodegradable Magnesium Alloy Implant in an Animal Model Using Near-Infrared Spectroscopy

Mathew, Anna; Hassan, Hafiz Wajahat; Korostynska, O.; Westad, Frank; Mota-Silva, Eduarda; Menichetti, Luca; Mirtaheri, Peyman

doi:10.3390/s23063063

Cited by 1 publication

(1 citation statement)

References 38 publications

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“…This suggests that reliable insights into the biological, physical, and mechanical properties of magnesium may only be obtained through in vivo testing. To achieve the goal of introducing magnesium implants to the market, there is a need to standardize in vitro models that specifically address the biological effect of magnesium in a manner relevant to this type of material [ 366 , 367 ]. Simultaneously, it is crucial to elucidate the behavior of potential alloy candidates through well-designed in vivo studies that employ high-resolution techniques and integrate them to obtain comprehensive insights into magnesium degradation within the human body [ 368 ].…”

Section: In Vivo Models For Magnesium-based Implantsmentioning

confidence: 99%

Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview

Hassan,

Krieg,

Kopp

et al. 2024

IJMS

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Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening and vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial for the development of these implants. To achieve implant success, an understanding of the cellular responses post-implantation, proper model selection, and good study design are crucial. There are several challenges to reaching a safe and effective translation of laboratory findings into clinical practice. The utilization of Mg-based biomedical devices eliminates the need for biomaterial removal surgery post-healing and mitigates adverse effects associated with permanent biomaterial implantation. However, the high corrosion rate of Mg-based implants poses challenges such as unexpected degradation, structural failure, hydrogen evolution, alkalization, and cytotoxicity. The biocompatibility and degradability of materials based on magnesium have been studied by many researchers in vitro; however, evaluations addressing the impact of the material in vivo still need to be improved. Several animal models, including rats, rabbits, dogs, and pigs, have been explored to assess the potential of magnesium-based materials. Moreover, strategies such as alloying and coating have been identified to enhance the degradation rate of magnesium-based materials in vivo to transform these challenges into opportunities. This review aims to explore the utilization of Mg implants across various biomedical applications within cellular (in vitro) and animal (in vivo) models.

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Section: In Vivo Models For Magnesium-based Implantsmentioning

confidence: 99%