In-vivo (Albino Mice) and in-vitro Assimilation and Toxicity of Zinc Oxide Nanoparticles in Food Materials

Abstract

Purpose Recent advances in nanotechnology have given rise to the potential utilization of nanoparticles as food, nano-medicine/biomedicines. Patient The study aimed to investigate the effects of nano-zinc oxide (nano-zinc) on the bio-assimilation of mineral (Zn) in mice, aged 3–6 weeks. Methods ZnO nanoparticles were added to the basal diet as a supplement at amounts of 0.07, 0.14 and 0.21 mg/kg. The synthesized material was characterized by Fourier transform infrared spectrophotometer, particle size, scanning electron microscope, Thermogravimetric Analysis Thermal, X-ray diffraction spectrophotometer and Zeta potential. Results In-vitro bioavailability of synthesized group ZnO (120 nm) was 43%, whereas for standard group ZnO (50 nm) was reported as 55%. In-vivo bioavailability of zinc oxide illustrated the maximum absorption level compared with the control. In-vivo toxicity was characterized as damage done to the liver and spleen tissues with a high dose of 0.21 mg/kg, while smaller doses indicated no toxic effects. Conclusion The study provided important insights on the toxicological effects of ZnO nanoparticles, depending on dose rate and bio-assimilation, as well as particles, under various conditions (in-vitro and in-vivo). These findings will motivate further detailed research on nano-based medicine for alleviating malnutrition conditions.

Synthesis, Characterization, Optical and Thermal Properties of P(NVC-co-BZMA) Copolymer and Its ZnO Composites

“…When the FT-IR spectrum of the P(NVC-co-BZMA) copolymer shown in Figure 2 was examined, the main peaks characterizing the copolymer were found as follows: peaks of aromatic C-H stretching vibrations between 2980-3048 cm -1 , peaks of aliphatic C-H stretching vibrations between 2840 and 2980 cm -1 , peak of ester carbonyl at 1723 cm -1 , peak of C=C stretching vibrations in the aromatic ring at 1450 cm -1 , peak of vinylidene at 1330 cm -1 , peaks of the (-C=O)-O-C group between 1156 and 1240 cm -1 , and peaks of C-H stretching vibrations of monosubstituted benzene at 695 cm -1 . The peak at 837 cm -1 , due to the nano ZnO, was below the peak at the same location in the composite structure and caused this peak to broaden (Haldar et al, 2011;Bashir et al, 2022).…”

Emerging Trends in the Application of Green Synthesized Biocompatible ZnO Nanoparticles for Translational Paradigm in Cancer Therapy

“…Results showed that the group treated with small-sized nanoparticles, having a higher surface area, exhibited a greater reduction in tumor size compared to the group treated with large-sized nanoparticles. This suggests that surface area influences the therapeutic effectiveness of zinc oxide nanoparticles in lung cancer treatment [28]. Moreover, the surface area of ZnO NPs can be modified through various surface modification techniques, including surface functionalization and doping, which can alter their physicochemical properties and improve their performance in specific applications.…”