In vivo activity of pseudoguaianolide sesquiterpene lactones in acute and chronic inflammation

Recio, M. C.; Giner, Rosa M.; Uriburu, L.; Máñez, Salvador; Cerdá, Miguel Jover; Fuente, Juana R. de la; Rı́os, José Luis

doi:10.1016/s0024-3205(00)00585-3

Cited by 67 publications

(50 citation statements)

References 24 publications

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“…Effects of the extracts on antigen-specific cellular immune response in mice were evaluated from degrees of DTH using footpad swelling test (Recio et al, 2000). Five groups of mice with six in each group were immunized by intraperitoneal injection with SE suspension (1 × 10 8 cells/0.2 ml PBS) at day 0.…”

Section: Effects Of Plant Crude Extracts On Delayed Type Hypersensitimentioning

confidence: 99%

In vivo immunomodulating activity of wood extracts from Clausena excavata Burm. f.

Manosroi

Saraphanchotiwitthaya

Manosroi

2005

Journal of Ethnopharmacology

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Section: Effects Of Plant Crude Extracts On Delayed Type Hypersensitimentioning

confidence: 99%

In vivo immunomodulating activity of wood extracts from Clausena excavata Burm. f.

Manosroi

Saraphanchotiwitthaya

Manosroi

2005

Journal of Ethnopharmacology

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“…Enzyme activity was determined colorimetrically, by measuring optical density (OD) at 450 nm. Activity is expressed as the OD/biopsy (Bradley et al, 1982;Recio et al, 2000;Susuki et al, 1983).…”

Section: Myeloperoxidase Assaymentioning

confidence: 99%

Anti-inflammatory effect of natural and semi-synthetic phthalides

Del-Ángel

Nieto

Ramírez‐Ápan

et al. 2015

European Journal of Pharmacology

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“…A carrageenan-induced paw oedema was executed according to methods described by Recio et al (2000), Smit et al (2000), Petersson et al (2001) and Huber et al (2002). Thirty female Sprague-Dawley rats were assigned to one of three groups; control group, experimental group and positive control group of ten rats each.…”

Section: Carrageenan-induced Paw Oedemamentioning

confidence: 99%

Potassium humate inhibits carrageenan-induced paw oedema and a graft-versus-host reaction in rats

2010

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It has been shown in a previous study that brown coal-derived potassium humate is safe and effective in suppressing contact hypersensitivity in rats. In this study the efficacy of potassium humate on other types of inflammation was determined. Preparative TLC followed by mass spectroscopy was used in an attempt to fingerprint the product. The effects of potassium humate, at an oral dose of 60 mg/kg bodyweight, on a delayed type hypersensitivity reaction, a carrageenan-induced inflammation model and an allogeneic graft-versus-host reaction (GVHR) in rats were investigated. Paw oedema was used as a measure of inflammation. It was found that potassium humate had no effect on the delayed type hypersensitivity reaction but significantly inhibited the increase in paw volume of the carrageenan-induced oedema in rats which compared favourably with indomethacin treatment. Furthermore, potassium humate inhibited the GVHR induced in normal and cyclophosphamide-treated immune-incompetent rats. The identification of a naturally occurring compound that is safe and effective in reducing different types of inflammation merits further evaluation in clinical trials.

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In vivo activity of pseudoguaianolide sesquiterpene lactones in acute and chronic inflammation

Cited by 67 publications

References 24 publications

In vivo immunomodulating activity of wood extracts from Clausena excavata Burm. f.

In vivo immunomodulating activity of wood extracts from Clausena excavata Burm. f.

Anti-inflammatory effect of natural and semi-synthetic phthalides

Potassium humate inhibits carrageenan-induced paw oedema and a graft-versus-host reaction in rats

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