In vivo activity of amoxicillin/clavulanic acid and erythromycin in experimental otitis media caused by Streptococcus pneumoniae plus Haemophilus influenzae

Parra, Araceli; Ponte, Carmen; Cenjor, Carlos; Garcı́a-Olmos, M.; Giménez, Marı́a José; Aguilar, Lorenzo; Soriano, Francisco

doi:10.1016/j.ijantimicag.2003.05.016

“…In the postmarketing phase, animal models have been used to study pharmacodynamic prediction of efficacy in systemic infections caused by strains with decreased susceptibility using humanized models [34], the relationship of pharmacodynamic parameter values with tissue injury [35], the effects of treatment delay on pharmacodynamics [35], the significance of local (as middle ear fluid) vs. serum pharmacodynamic parameters in local infections (otitis media) [36], pharmacodynamics in mixed local infections (S. pneumoniae þ H. influenzae) [37], the effect of the disease (acute otitis media vs. otitis media with effusion) on pharmacodynamics in middle ear fluid [38], or the effect of concomitant medications as analgesics on the relationship between pharmacodynamic parameters and eradication [39,40].…”

Section: The In-vivo Linkmentioning

confidence: 99%

Gaps in antibiotic development: the postmarketing task

Aguilar¹,

Giménez²

2008

Reviews in Medical Microbiology

View full text Add to dashboard Cite

Antibiotic development is mainly focused on demonstrating clinical efficacy and setting susceptibility breakpoints. However, several issues cannot be addressed at the premarketing stage. Any ecological effects on human microbiota, as well as effects on mixed inocula selecting bacterial populations in species, strains within species, or subpopulations within strains, need to be addressed and can be explored in the laboratory using pharmacodynamic simulator devices as predictors of resistance selection. From the social perspective, relationships between the consumption of a compound and resistance can only be performed postmarketing. Specific resistance phenotypes/genotypes that could not be isolated in enough numbers in clinical trials can be examined in pharmacodynamic devices in the laboratory for comparison with other antibiotics and thereby for determination of the compound that best fits the need to counter the development/emergence and further spread of resistance.

show abstract

In Vitro and in Vivo Models for Pathogenic Neisseria gonorrhoeae Infections

Ramalingam

¹

,

Ganesh

²

2022

Research Anthology on Advancements in Women's Health and Reproductive Rights

0

View full text Add to dashboard Cite

The prevalence of gonorrhea has not discontinued in several countries and still remains as one of the top sexually transmitted diseases (STD) and it's caused by Neisseria gonorrhoeae. This bacterium gains entry into the human host via receptors, and by the usage of several virulence factors, it manages to spread through the cells and leads to severe complications. The study of these bacteria in various in vitro and in vivo models have paved the way for gaining insights on various aspects of bacterial infection, such as the study of pathogenesis of the organism in the host. It also drove the development of more appropriate drugs for the treatment of the gonorrhea illness caused by this ‘superbug'. This chapter focuses on providing a concise overview on the general aspects of N. gonorrhoeaeas an update and the in vitro and in vivo models used for understanding this bacterium over the years. Despite gonorrhea not being a rare STD, it is still a big challenge for researchers, healthcare professionals, and communicators with public awareness to communicate effectively with the general community.

show abstract

In Vitro and in Vivo Models for Pathogenic Neisseria gonorrhoeae Infections

Ramalingam

¹

,

Ganesh

²

2021

Epidemiological Research Applications for Public Health Measurement and Intervention

0

View full text Add to dashboard Cite

The prevalence of gonorrhea has not discontinued in several countries and still remains as one of the top sexually transmitted diseases (STD) and it's caused by Neisseria gonorrhoeae. This bacterium gains entry into the human host via receptors, and by the usage of several virulence factors, it manages to spread through the cells and leads to severe complications. The study of these bacteria in various in vitro and in vivo models have paved the way for gaining insights on various aspects of bacterial infection, such as the study of pathogenesis of the organism in the host. It also drove the development of more appropriate drugs for the treatment of the gonorrhea illness caused by this ‘superbug'. This chapter focuses on providing a concise overview on the general aspects of N. gonorrhoeaeas an update and the in vitro and in vivo models used for understanding this bacterium over the years. Despite gonorrhea not being a rare STD, it is still a big challenge for researchers, healthcare professionals, and communicators with public awareness to communicate effectively with the general community.

show abstract

In vivo activity of amoxicillin/clavulanic acid and erythromycin in experimental otitis media caused by Streptococcus pneumoniae plus Haemophilus influenzae

Cited by 3 publications

References 22 publications

Gaps in antibiotic development: the postmarketing task

Gaps in antibiotic development: the postmarketing task

In Vitro and in Vivo Models for Pathogenic Neisseria gonorrhoeae Infections

In Vitro and in Vivo Models for Pathogenic Neisseria gonorrhoeae Infections

Contact Info

Product

Resources

About