In vivo acoustic attenuation in liver: Correlations with blood tests and histology

Duerinckx, André J.; Rosenberg, Kevin; Hoefs, John C.; Aufrichtig, D; Cole-Beuglet, C; Kanel, Gary C.; Lottenberg, Stephen; Ferrari, Leonard A.

doi:10.1016/0301-5629(88)90076-2

Cited by 19 publications

(6 citation statements)

References 23 publications

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“…Non-tumorous tissue was evaluated in all samples from patients with focal masses. Liver fat was determined as the percentage of fat-containing hepatocytes on hematoxylin and eosin staining [18] using a standard visualization technique [19]. A standard grading system employed in clinical practice was used for determining steatosis grade ranging from 0 to 3, with 0 representing <5%; 1, ≥5% to <33%; 2, ≥33% to <66%; and 3, ≥66% of hepatocytes containing fat, respectively [16].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of diffuse liver steatosis by ultrasound, computed tomography, and magnetic resonance imaging: which modality is best?

et al. 2009

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Purpose To compare ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) determination of diffuse liver steatosis. Materials and methods Quantification of liver steatosis on ultrasound, CT, and MRI was correlated with histopathology in 67 patients. Results Opposed-phase MRI demonstrated the highest correlation with steatosis (0.68 and 0.69, P<.01; intraclass correlation coefficient, 0.93). Spearman’s correlation (and intraclass correlation) coefficients were lowest for ultrasound [0.54, 0.33 (0.40)] and enhanced CT [0.33, 0.39 (0.97)]. Conclusion Opposed-phase MRI demonstrated best overall performance for determining steatosis.

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Section: Methodsmentioning

confidence: 99%

Evaluation of diffuse liver steatosis by ultrasound, computed tomography, and magnetic resonance imaging: which modality is best?

et al. 2009

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“…We used a more detailed technique with a continuous measurement of liver fat (0%, which indicated no hepatocytes with steatosis, to 100%, which indicated steatosis of all hepatocytes) rather than a large grouping of percentages of fat. Fat content was determined as the percentage of fat-containing hepatocytes in hematoxylin-eosin-stained specimens, as determined with standardized visual analysis (11).…”

Section: Histopathologic Analysismentioning

confidence: 99%

Accuracy of Liver Fat Quantification at MR Imaging: Comparison of Out-of-Phase Gradient-Echo and Fat-saturated Fast Spin-Echo Techniques—Initial Experience

Qayyum¹,

Goh²,

Kakar³

et al. 2005

Radiology

167

148

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“…Liver steatosis grade was determined by estimating the percentage of fat-containing hepatocytes on hematoxylin-eosin-stained specimens (15,16). The grading system for liver steatosis was based on that used in prior studies (15): grade 0 corresponding to less than 5% steatosis; grade 1, 6%-33% steatosis; grade 2, 34%-66% steatosis; and grade 3, greater than 66% steatosis.…”

Section: Histopathologic Analysismentioning

confidence: 99%

Liver Steatosis: Investigation of Opposed-Phase T1-weighted Liver MR Signal Intensity Loss and Visceral Fat Measurement as Biomarkers

Bahl¹,

Qayyum²,

Westphalen³

et al. 2008

Radiology

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Purpose:To investigate if opposed-phase T1-weighted and fat-suppressed T2-weighted liver signal intensity (SI) loss and visceral fat measurement at magnetic resonance (MR) imaging and body mass index (BMI) are correlated with grade of liver steatosis in patients with nonalcoholic fatty liver disease (NAFLD) or hepatitis C virus (HCV) and human immunodeficiency virus (HIV)-related liver disease. Materials and Methods:Committee on Human Research approval and patient consent were obtained for this HIPAA-compliant study. Fiftytwo patients (15 men, 37 women) with NAFLD (n ϭ 29) or HCV and HIV-related liver disease (n ϭ 23) underwent prospective contemporaneous MR imaging and liver biopsy. Liver SI loss was measured on opposed-phase T1-weighted and fat-suppressed T2-weighted MR images. Visceral fat area was measured at three levels on watersuppressed T1-weighted MR images (n ϭ 44). Spearman rank correlation coefficients and recursive partitioning were used to examine correlations. Results:Histopathologic liver steatosis correlated well with liver SI loss on opposed-phase T1-weighted MR images ( ϭ 0.78), fat-suppressed T2-weighted MR images ( ϭ 0.75), and average visceral fat area ( ϭ 0.77) (all P Ͻ .01) but poorly with BMI ( ϭ 0.53, P Ͻ .01). Liver SI losses on opposed-phase T1-weighted MR imaging of less than 3%, at least 3% but less than 35%, at least 35% but less than 49%, and at least 49% corresponded to histopathologic steatosis grades of 0 (n ϭ 16 of 17), 1 (n ϭ 11 of 16), 2 (n ϭ 7 of 13), and 3 (n ϭ 5 of 6), respectively. A visceral fat area of greater than or equal to 73.8 cm 2 was associated with the presence of histopathologic steatosis in 41 of 44 patients.

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In vivo acoustic attenuation in liver: Correlations with blood tests and histology

Cited by 19 publications

References 23 publications

Evaluation of diffuse liver steatosis by ultrasound, computed tomography, and magnetic resonance imaging: which modality is best?

Evaluation of diffuse liver steatosis by ultrasound, computed tomography, and magnetic resonance imaging: which modality is best?

Accuracy of Liver Fat Quantification at MR Imaging: Comparison of Out-of-Phase Gradient-Echo and Fat-saturated Fast Spin-Echo Techniques—Initial Experience

Liver Steatosis: Investigation of Opposed-Phase T1-weighted Liver MR Signal Intensity Loss and Visceral Fat Measurement as Biomarkers

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