In vivo [3H]spiperone binding to the rat hippocampal formation: Involvement of dopamine receptors

Autoradiographic localization of dopamine D1 and D2 receptors in the brain of several mammalian species

“…these results also agree with data from other authors on the localization of D 1 and D 2 receptors in human (Camps et al, 1988;Cort6s et al, 1988), cat (Dolphin et al. 1979~ and rat hippocampus (Baudry et al, 1979;Bischoff et al, 1980;Boyson et al, 1986;Charuchinda et al, 1987;Dubois et al, 1986;Savasta et al, 1986). On the other hand.…”

Dopamine Receptor Gene Expression in the Human Medial Temporal Lobe

“…The dopaminergic innervation of the medial tem poral lobe originates in the midbrain, especially from the ventral tegmental area, but there are afferent &bers from the substantia nigra as well (Scatton et al 1980;Ferraro et al 1991). Both D1-and D2-like receptors ap pear to be located within the medial temporal lobe (Dewar and Reader 1989;Diop et al 1988;Bruinink and Bischoff 1986;Bischoff et al 1980), and both receptor subtypes appear to be functionally coupled to adenyl ate cyclase (Grilli et al 1988 Berretta et al 1990;Yanagihashi et al 1991;Bijak 1987, 1989), including long-term potentiation (Yanagihashi and Ishikawa 1992;Frey et al 1989Frey et al , 1990Frey et al , 1991, and both have been implicated in the mediation of certain animal behaviors (Borker and Mascarenhas 1991;Pack ard and White 1989). Anatomical demonstrations of dopaminergic inner vation of the medial temporal lobe have also been per formed using a variety of techniques (Fallon et al 1978).…”

Autoradiographic localization of extrastriatal D2-dopamine receptors in the human brain using [125I]epidepride

“…The highest D2-dopamine receptor densities have been found in the caudate nucleus and putamen, as demonstrated by in vitro homogenate studies (Seeman, 1980;Hall et al, 1988 and in vitro autoradiography (Kessler et al, 1993;Hall et al, 19941, and confirmed in vivo using positron emission tomography (PET) (Farde et al, 1986). The density is lower in the nucleus accumbens (Berendse and Richfield, 1993;Kessler et al, 19931, and there are only minute populations of Dz-dopamine receptors in extrastriatal regions such as the neocortex, entorhinal cortex, and hippocampus (Bischoff et al, 1980;Lidow et al, 1989;Hall et al, 1991;Goldman-Rakic et al, 1992;Kessler et al, 1993). There is growing evidence that the extrastriatal Dz-dopamine receptors, in spite of low density, have functional significance and may be targets for antipsychotic drugs.…”