In vivo 1H MRS choline: Correlation with in vitro chemistry/histology

Miller, Bruce L.; Changl, Linda; Booth, Ruth A.; Ernst, Thomas; Cornford, Marcia E.; Nikas, Diana L.; McBride, Duncan Q.; Jenden, Donald J.

doi:10.1016/0024-3205(96)00182-8

Cited by 343 publications

(190 citation statements)

References 12 publications

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“…The Cho resonance contains contributions from phosphocholine and glycerophosphorylcholine; available evidence suggests that glycerophosphorylcholine, which comprises at least half of the MR-visible peak (Miller et al, 1996), is a cerebral osmolyte (Lien et al, 1990;Videen et al, 1995). Chronic renal failure, for example, associated with a prolonged hyerposmotic state, demonstrates a positive correlation between MRS-derived Cho and serum osmotic pressure (Sasaki et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

A Mechanism of Rapidly Reversible Cerebral Ventricular Enlargement Independent of Tissue Atrophy

Zahr

Mayer

Rohlfing

et al. 2013

Neuropsychopharmacol

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Ventricular enlargement, a common in vivo marker of aging, disease, and insult, is presumed to reflect atrophy of surrounding brain regions. Pathological mechanisms underlying ventricular enlargement, however, are likely specific to the condition under investigation. Here, multimodal imaging, incorporating structural magnetic resonance imaging (MRI), MR spectroscopy (MRS), and diffusion weighted imaging (DWI), was used in rats exposed to binge ethanol (EtOH) to provide insight into a mechanism of reversible ventricular enlargement. During intoxication, MRI revealed expansion of ventricles, but volume changes in dorsal or ventral hippocampi, caudateputamen, or thalamus were not detectible. MRS of whole-brain parenchyma showed decreases in N-acetylasparate (NAA) and tissue water T2, and increases in choline-containing compounds (Cho). DWI showed decreased diffusivity selective to the thalamus. All MR parameters returned to baseline with 7 days of recovery. Rapid recovery of ventricular volume and the absence of detectable tissue volume reductions in brain regions adjacent to ventricles argue against atrophy as a mechanism of ventricular expansion. Decreased tissue water T2 and decreased thalamic diffusivity suggest lower tissue water content and a role for both NAA and Cho, as osmolytes is proposed. Together, these data support a model of fluid redistribution during acute EtOH intoxication and recovery to account for rapid ventricular volume changes.

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Section: Discussionmentioning

confidence: 99%

A Mechanism of Rapidly Reversible Cerebral Ventricular Enlargement Independent of Tissue Atrophy

Zahr

Mayer

Rohlfing

et al. 2013

Neuropsychopharmacol

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“…Furthermore, the choline resonance has been correlated with cell density and with indices of cellular proliferation (Miller et al, 1996). The detected decrease in choline could be a consequence of the therapeutic effect of temozolomide and subsequent neoplastic cell death.…”

Section: Metabolic Changesmentioning

confidence: 99%

Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy

et al. 2004

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Assessment of low-grade glioma treatment response remains as much of a challenge as the treatment itself. Proton magnetic resonance spectroscopy ( 1 H-MRS) and imaging were incorporated into a study of patients receiving temozolomide therapy for lowgrade glioma in order to evaluate and monitor tumour metabolite and volume changes during treatment. Patients (n ¼ 12) received oral temozolomide (200 mg m À2 day À1 ) over 5 days on a 28-day cycle for 12 cycles. Response assessment included baseline and three-monthly magnetic resonance imaging studies (pretreatment, 3, 6, 9 and 12 months) assessing the tumour size. Short (TE (echo time) ¼ 20 ms) and long (TE ¼ 135 ms) echo time single voxel spectroscopy was performed in parallel to determine metabolite profiles. The mean tumour volume change at the end of treatment was À33% (s.d. ¼ 20). The dominant metabolite in long echo time spectra was choline. At 12 months, a significant reduction in the mean choline signal was observed compared with the pretreatment (P ¼ 0.035) and 3-month scan (P ¼ 0.021). The reduction in the tumour choline/water signal paralleled tumour volume change and may reflect the therapeutic effect of temozolomide.

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“…By providing in vivo estimates of Ch concentration, MR spectroscopy is thought to provide information on membrane turnover (Gadian, 1995), the degree of myelination (Hida et al, 1992), and cell density (Miller et al, 1996). The Ch concentration is reported to vary with the production and degradation of the Ch-containing phospholipids, which are abundant in cell membrane and in myelin (Miller et al, 1996;Alberts et al, 2002;Styor, 1988). An abnormality in membrane structure or myelination could precipitate decreased synaptic strength and efficiency, manifesting in cognitive deficits.…”

Section: Resultsmentioning

confidence: 99%

Brain Metabolites and Cognitive Function among Older Depressed and Healthy Individuals Using 2D MR Spectroscopy

Elderkin‐Thompson

Thomas

Binesh

et al. 2004

Neuropsychopharmacol

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Brain metabolites of choline (Ch) and myo-Inisotol (mI) have been reported as elevated among geriatric depressed patients. Twodimensional (2D) magnetic resonance spectroscopy (MRS) provides estimates of Ch, mI, and creatine (Cr) similar to one-dimensional MRS, and it also estimates the resonances of the Ch-containing compounds of phosphoethanolamine (Pe) and phosphocholine (PCh). In this cross-sectional geriatric study, 14 depressed patients and 14 healthy volunteers who were comparable in age, gender, education, comorbid medical burden, and Mini-Mental State Examination (MMSE) scores completed 2D MRS and a neurocognitive battery. A voxel in the left dorsolateral cortex, which was comprised of approximately 60% white matter, was used to estimate the CR ratios of Ch, PCh, Pe, and mI. Composite scores for cognitive function were developed for verbal learning, recall, recognition, executive function, hypothesis generation, and processing speed. Among nondepressed subjects, cognition was positively correlated with Ch/Cr and mI/Cr and negatively correlated with PCh/Cr in four domains of verbal learning, recognition, recall, and hypothesis generation. In contrast, depressed patients did not have consistent relationships between Ch/Cr, mI/Cr, and PCh/Cr and cognition. There was a significant difference in the overall pattern of associations between the four metabolites and verbal learning and processing speed in depressed patients compared to healthy controls. The attenuated relationship between metabolites and specific cognitive domains in patients with late-life MDD suggests that the level of cognitive performance observed during depressive episodes may be associated with changes in biochemistry within the frontostriatal neuronal circuitry.

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In vivo 1H MRS choline: Correlation with in vitro chemistry/histology

Cited by 343 publications

References 12 publications

A Mechanism of Rapidly Reversible Cerebral Ventricular Enlargement Independent of Tissue Atrophy

A Mechanism of Rapidly Reversible Cerebral Ventricular Enlargement Independent of Tissue Atrophy

Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy

Brain Metabolites and Cognitive Function among Older Depressed and Healthy Individuals Using 2D MR Spectroscopy

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