In vitro Vasorelaxant Effect of Artemisia herba alba Asso. in Spontaneously Hypertensive Rats

Naoufel, Zeggwagh; Hebi, Morad; Ajebli, Mohammed; Michel, Jean Baptiste; Eddouks, Mohamed

doi:10.2174/1871525714666161216100044

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“…Artemisia herba-alba is a spontaneous aromatic plant frequently used in Algerian and Tunisian traditional medicine (Qnais et al 2014, Aidi Wannes and Marzouk 2016, Najjaa et al 2017 to relieve gastric disorders with antispasmodic, hypoglycemiant, anti-inflammatory properties (Lee et al 2012), vasorelaxant (Naoufel et al 2016) and diabetes treatment (Aidi Wannes and Marzouk 2016, Telli et al 2016, Bushara et al 2017, El-Marasy et al 2017.…”

Section: Complementary Introductionmentioning

confidence: 99%

Synergistic antinociceptive activity of combined aqueous extracts of Artemisia campestris and Artemisia herba-alba in several acute pain models

Kadi

Ouinten

Gourine

et al. 2017

Natural Product Research

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In this study, total phenolic and flavonoid contents, acute toxicity and the antinociceptive activity of Artemisia campestris and Artemisia herba-alba, individually and in combination, were investigated using multiple forms of pain in animals. Our results have been shown that plants are relatively safe without clinical signs of toxicity in animals. Thus, extracts were presented high levels in phenolic and flavonoid contents. Artemisia decoctions with 100, 200, 400 mg/kg b-w studied dose, clearly attenuate chemical and thermal noxious stimuli in writhing, formalin and hot-plate tests, and significantly reduced paw oedema in formalin test. Additionally, binary combination forms exhibited a great improvement in intensity and amplitude of antinociceptive activity in comparison with both plants used individually by a relative interference with opioid system. Our findings suggested the central and peripheral analgesic properties and confirmed the folkloric medicinal use of these plants in pain symptom treatment.

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Section: Complementary Introductionmentioning

confidence: 99%

Synergistic antinociceptive activity of combined aqueous extracts of Artemisia campestris and Artemisia herba-alba in several acute pain models

Kadi

Ouinten

Gourine

et al. 2017

Natural Product Research

View full text Add to dashboard Cite

show abstract

In vitro Vasorelaxant Effect of Artemisia herba alba Asso. in Spontaneously Hypertensive Rats

Abstract: We conclude that aqueous Ah extract at a dose of 20 mg/ml possess an in vitro vasorelaxant effect which seems to be dependent on the endothelium vasorelaxant factors involving nitric oxide synthesis.

Cited by 1 publication

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Synergistic antinociceptive activity of combined aqueous extracts of Artemisia campestris and Artemisia herba-alba in several acute pain models

Synergistic antinociceptive activity of combined aqueous extracts of Artemisia campestris and Artemisia herba-alba in several acute pain models

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