In-Vitro Use of Verteporfin for Photodynamic Therapy in Glioblastoma

Jeising, Sebastian; Geerling, Gerd; Guthoff, Rainer; Hänggi, Daniel; Sabel, Michael; Rapp, Marion; Nickel, Ann-Christin

doi:10.1016/j.pdpdt.2022.103049

Cited by 9 publications

(7 citation statements)

References 29 publications

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“…PDT is increasingly used in the treatment of various solid tumors, including the brain, head and neck, lungs, gastrointestinal tract, bones, urinary bladder, prostate, breast, cervix and ovary ( 93 , 227 , 228 ).…”

Section: Review Of the Literaturementioning

confidence: 99%

The use of photodynamic therapy in medical practice

Aebisher,

Rogóż,

Myśliwiec

et al. 2024

Front. Oncol.

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Cancer therapy, especially for tumors near sensitive areas, demands precise treatment. This review explores photodynamic therapy (PDT), a method leveraging photosensitizers (PS), specific wavelength light, and oxygen to target cancer effectively. Recent advancements affirm PDT’s efficacy, utilizing ROS generation to induce cancer cell death. With a history spanning over decades, PDT’s dynamic evolution has expanded its application across dermatology, oncology, and dentistry. This review aims to dissect PDT’s principles, from its inception to contemporary medical applications, highlighting its role in modern cancer treatment strategies.

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Section: Review Of the Literaturementioning

confidence: 99%

The use of photodynamic therapy in medical practice

Aebisher,

Rogóż,

Myśliwiec

et al. 2024

Front. Oncol.

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“…58 Verteporfin consists of a porphyrin ring, C41H42N4O8, and produces reactive oxygen radicals upon exposure to a wave length of 690 nm that result in cell apoptosis and prevents angiogenesis and tumor proliferation. 18,59,60 Verteporfin is used intraoperatively to visualize and delineate the tumor margins under blue light (with a wavelength of 400-410 nm). 14 This enables the surgeons to maximize the extent of resection and spare the normal brain parenchyma as much as possible.…”

Section: Yap/taz-tead Pathway and Microenvironment Of Idh Wild-type G...mentioning

confidence: 99%

The impact of interaction between verteporfin and yes-associated protein 1/transcriptional coactivator with PDZ-binding motif-TEA domain pathway on the progression of isocitrate dehydrogenase wild-type glioblastoma

Osama,

Essibayi,

Osama

et al. 2023

J Cent Nerv Syst Dis

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Verteporfin and 5-ALA are used for visualizing malignant tissue components in different body tumors and as photodynamic therapy in treating isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM). Additionally, verteporfin interferes with Yes-associated protein 1 (YAP)/Transcriptional coactivator with PDZ-binding motif - TEA domain (TAZ-TEAD) pathway, thus inhibiting the downstream effect of these oncogenes and reducing the malignant properties of GBM. Animal studies have shown verteporfin to be successful in increasing survival rates, which have led to the conduction of phase 1 and 2 clinical trials to further investigate its efficacy in treating GBM. In this article, we aimed to review the novel mechanism of verteporfin’s action, the impact of its interaction with YAP/TAZ-TEAD, its effect on glioblastoma stem cells, and its role in inducing ferroptosis.

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“…The application of fluorescence‐guided surgery (FGS) in combination with photodynamic therapy (PDT) has demonstrated enhanced efficacy in the resection of GBM and elimination of tumor residual. [ 5 ] To date, at least 3 fluorescent contrast agents, including indocyanine green, 5‐aminolevulinic acid, and methylene blue, have been successfully applied in clinical settings for FGS. [ 6 ] Fluorescent contrast agents such as 5‐aminolevulinic acid can also serve as photosensitizers for PDT, enabling the combination therapy of PDT and FGS.…”

Section: Introductionmentioning

confidence: 99%

Self‐Disassembling and Oxygen‐Generating Porphyrin‐Lipoprotein Nanoparticle for Targeted Glioblastoma Resection and Enhanced Photodynamic Therapy

Chen,

Ma,

Shi

et al. 2024

Advanced Materials

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The dismal prognosis for glioblastoma multiform (GBM) patients is primarily attributed to the highly invasive tumor residual that remained after surgical intervention. The development of precise intraoperative imaging and postoperative residual removal techniques will facilitate the gross total elimination of GBM. Here, we developed a self‐disassembling porphyrin lipoprotein‐coated calcium peroxide nanoparticles (PLCNP) to target GBM via macropinocytosis, allowing for fluorescence‐guided surgery of GBM and improving photodynamic treatment (PDT) of GBM residual by alleviating hypoxia. By reducing self‐quenching and enhancing lysosome escape efficiency, the incorporation of calcium peroxide (CaO2) cores in PLCNP amplified the fluorescence intensity of porphyrin‐lipid. Furthermore, the CaO2 core has diminished tumor hypoxia and improved the PDT efficacy of PLCNP, enabling low‐dose PDT and reversing tumor progression induced by hypoxia aggravation following PDT. Taken together, this self‐disassembling and oxygen‐generating porphyrin‐lipoprotein nanoparticle may serve as a promising all‐in‐one nanotheranostic platform for guiding precise GBM excision and empowering post‐operative PDT, providing a clinically applicable strategy to combat GBM in a safe and effective manner.This article is protected by copyright. All rights reserved

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In-Vitro Use of Verteporfin for Photodynamic Therapy in Glioblastoma

Cited by 9 publications

References 29 publications

The use of photodynamic therapy in medical practice

The use of photodynamic therapy in medical practice

The impact of interaction between verteporfin and yes-associated protein 1/transcriptional coactivator with PDZ-binding motif-TEA domain pathway on the progression of isocitrate dehydrogenase wild-type glioblastoma

Self‐Disassembling and Oxygen‐Generating Porphyrin‐Lipoprotein Nanoparticle for Targeted Glioblastoma Resection and Enhanced Photodynamic Therapy

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