In-vitro-Untersuchungen zur entzündungshemmenden Wirkung von Eupatorium perfoliatum (EP)

Caffeic Acid Derivatives from Eupatorium perfoliatum L.

“…An alkaline-soluble polysaccharide fraction was shown to exhibit immunostimulating activities under in vitro conditions [14,15,16]. Furthermore, investigations concerning antiinflammatory [17, 18], cytotoxic and antibacterial [19] as well as antiprotozoal [20] activities have been carried out. The few clinical studies dealing with different preparations of E. perfoliatum only partly support the phytotherapeutic indications [21,22,23].…”

Eupatorium perfoliatum L.: Phytochemistry, traditional use and current applications

“…An EtOH extract was prepared as mother tincture according to homeopathic regulations, and was investigated in vitro on human monocytes concerning the influence on induction of inflammatory cytokines (Nauert et al, 2006). Results confirmed a dose-dependent reduction of IL-1 and PGE2, while MMP-1 has not been influenced.…”

Anti-inflammatory activity of Eupatorium perfoliatum L. extracts, eupafolin, and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines

“…These polysaccharides, extracted from the drug material by strong alkaline solvent, will probably not be present in ethanolic extracts, which means that these data do not have relevance for the traditional and practical use of the preparation. Furthermore, an ethanolic extract was shown to decrease the formation of IL-1 and PGE 2 under in vitro conditions in human monocytes (Nauert et al, 2006). On the other side only at very high concentrations (100 mg/kg body weight) a slight inhibition (−12%) of carrageenan induced inflammation in rats was observed for the ethanolic extract (Benoit et al, 1976).…”