In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies

Rahmanian, Mehdi; Seyfoori, Amir; Ghasemi, Mohsen; Shamsi, Milad; Kolahchi, Ahmad Rezaei; Modarres, Hassan Pezeshgi; Sanati‐Nezhad, Amir; Majidzadeh‐A, Keivan

doi:10.1016/j.jconrel.2021.04.024

Cited by 20 publications

(10 citation statements)

References 190 publications

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“…Microfluidic systems enable the multiplexed drug screening in a simple and high-throughput manner, from the cell level to the organ-, even whole-body levels. Recent studies also revealed the impressive progresses of microfluidic systems in modeling the drug resistance tumor models, which would promote the development of multidrug delivery treatment strategies ( Rahmanian et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization

Fan²,

Ding³

et al. 2022

Front. Genet.

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With continued advances in cancer research, the crucial role of the tumor microenvironment (TME) in regulating tumor progression and influencing immunotherapy outcomes has been realized over the years. A series of studies devoted to enhancing the response to immunotherapies through exploring efficient predictive biomarkers and new combination approaches. The microfluidic technology not only promoted the development of multi-omics analyses but also enabled the recapitulation of TME in vitro microfluidic system, which made these devices attractive across studies for optimization of immunotherapy. Here, we reviewed the application of microfluidic systems in modeling TME and the potential of these devices in predicting and monitoring immunotherapy effects.

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Section: Discussionmentioning

confidence: 99%

Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization

Fan²,

Ding³

et al. 2022

Front. Genet.

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“…Multidrug resistance is a major obstacle threatening human health . Mounting studies have shown that miR can reverse drug resistance by inhibiting cell proliferation, inducing cell apoptosis, reversing EMT, promoting metabolism, and so on. , However, as a kind of nucleic acid, miR has several defects, such as easy degradation, instability, and difficulty entering cells, which significantly limit its application in vivo .…”

Section: Discussionmentioning

confidence: 99%

Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer

Yang

Shang

et al. 2021

Mol. Pharmaceutics

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In this study, a chitosan-based, self-assembled nanosystem that codelivered microRNA34a (miR34a) and doxorubicin (Dox) with hyaluronic acid (HA) modification (named CCmDH NPs) was developed to reverse the resistance of breast cancer (BCa) cells to Dox. The CCmDH NPs had a diameter of 180 ± 8.3 nm and a ζ potential of 16.5 mV with a slow-release effect for 96 h. The codelivery system could protect miR34a from nuclease and serum degradation and transport miR34a and Dox into drug-resistant MCF-7/A cells. In addition, the CCmDH NPs could inhibit proliferation and promote apoptosis by regulating the protein expression of B-cell lymphoma-2 (Bcl-2) and poly(ADP-ribose) polymerase (PARP) and inhibit invasion, metastasis, and adhesion by regulating E-cadherin, N-cadherin, MMP2, CD44, and Snail molecules. The CCmDH NPs induced a 73.7% tumor reduction in xenograft tumor growth in nude mice in vivo. This study provides evidence for the anticancer activity of CCmDH NPs carrying Dox and miR34a in BCa, especially metastatic Dox-resistant BCa models.

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“…A significant progress has occurred in the realm of cancer therapy by deliberately targeting heterotypic interactions that occur prior to metastasis. When it comes to quantitative assessments of heterotypic signaling, there are relatively few in vitro systems capable of reproducible tissue morphology that can be used for a variety of other types of studies; this is in contrast to the relatively few in vitro systems capable of reproducible tissue morphology that can be used for drug development [94,95]. Rather than the conventional 2D petri dish culture, 3D culture gives a more realistic portrayal of tissue and matrix structure [49].…”

Section: D Tumor Microenvironment Modelingmentioning

confidence: 99%

“…In the laboratory, EPR events have been demonstrated to be hard to adequately replicate using conventional in vitro 2D models. When a solid tumor becomes fibrotic, it develops an increased stiffness, which the illness exacerbates [95,263].…”

Section: Microfluidic Design Considerationsmentioning

confidence: 99%

Functional biomaterials for biomimetic 3D in vitro tumor microenvironment modeling

Ahmed

2023

In vitro models

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The translational potential of promising anticancer medications and treatments may be enhanced by the creation of 3D in vitro models that can accurately reproduce native tumor microenvironments. Tumor microenvironments for cancer treatment and research can be built in vitro using biomaterials. Three-dimensional in vitro cancer models have provided new insights into the biology of cancer. Cancer researchers are creating artificial three-dimensional tumor models based on functional biomaterials that mimic the microenvironment of the real tumor. Our understanding of tumor stroma activity over the course of cancer has improved because of the use of scaffold and matrix-based three-dimensional systems intended for regenerative medicine. Scientists have created synthetic tumor models thanks to recent developments in materials engineering. These models enable researchers to investigate the biology of cancer and assess the therapeutic effectiveness of available medications. The emergence of biomaterial engineering technologies with the potential to hasten treatment outcomes is highlighted in this review, which also discusses the influence of creating in vitro biomimetic 3D tumor microenvironments utilizing functional biomaterials. Future cancer treatments will rely much more heavily on biomaterials engineering.

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In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies

Cited by 20 publications

References 190 publications

Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization

Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization

Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer

Functional biomaterials for biomimetic 3D in vitro tumor microenvironment modeling

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