In vitro trials of a wearable artificial kidney (WAK)

Bazaev, N. A.; Dorofeeva, Nataliya I; Zhilo, Nikita M.; Streltsov, Evgeniy V.

doi:10.5301/ijao.5000651

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…The medical error also leads to 14% of death in dialysis [5]. In Kenya, 18 dialysis patients die per day due to the unavailability of machine [29].…”

Section: Quietus Ratementioning

confidence: 99%

“…[17]The steps towards physician less dialysis is very much less in the current mechanism, but the project device is well enhanced with the safety measures using sensor alert systems. By increasing rate of capillary gravitational pressure in the machine with cycled liquid flow in our project device [29], the role play if blood pump becomes unneeded. In order to make the device as the easy portable one some of the inbuilt gadgets have been miniaturized with microcontrollers.…”

Section: Comparitive Analysismentioning

confidence: 99%

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Design and Development of the Novel Technology for the Treatment of Patients with the Acute and Chronic Renal Failure

2019

IJITEE

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Kidney failure is a condition where the function of kidney gets disabled. In order to sustain in life, dialysis is predominantly adopted. The dialysis is a technical replacement of function of kidney and it is of two types. In considering the long term blood filtering process, the hemodialysis will be an efficient device in replacing the renal functioning but it was currently performed in the stationary mode. In order to fulfill the life supporting requirement, the “Miniaturized portable hemodialysis” device has been introduced which will be portable than the conventional ones. In order to enhance their features, the chambered dialysate technology and the specialized filtering mechanism has been fabricated to this project device. In the process of rectifying the technical errors, sensor indications are implemented for safety measures. In focusing towards the portable mechanism, the battery backup has been applied in this device which can perform patient dialysis in transferable mode.

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“…The medical error also leads to 14% of death in dialysis [5]. In Kenya, 18 dialysis patients die per day due to the unavailability of machine [29].…”

Section: Quietus Ratementioning

confidence: 99%

Section: Comparitive Analysismentioning

confidence: 99%

Design and Development of the Novel Technology for the Treatment of Patients with the Acute and Chronic Renal Failure

2019

IJITEE

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“…In case of long term of medication, the patients will get affected under peritoneal sclerosis Bazae V et. al., have presented the results of a wearable artificial kidney-WAK through in-vitro trials [24].The in-vitro trial of their experimental prototype of wearable artificial kidney was carried out on the test bench. They also discussed about expendable materials which are used to replace infrequently as once every one and a half day that lowers the risk of peritonitis up to 6 times, which was discussed by the research people.…”

Section: Sabithavadakedathmentioning

confidence: 99%

Design of Mobile Hemodialysis Apparatus for Acute Renal Failure Patient's Self-Help and Treatment Adherence

2019

ijrte

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The major intend of the nephrologists is to reduce the hardships faced by the patients affected with renal ailments. Kidney failure or renal failure is a condition where the function of kidney gets disabled/affected at large. This condition may neither be temporary or lifelong but in order to sustain in life, dialysis was adopted. The dialysis is a technical replacement of function of kidney and its process has two sectors; peritoneal dialysis and hemodialysis. In considering the long term blood filtering process, the hemodialysis will be an efficient device in replacing the renal functioning, but it was currently performed in the stable mode. In undergoing the deep survey, our team has analyzed that the major problem in the dialysis is the duration, cost, difficulties faced by the patients. In order to overcome these barriers, the prototype of the portable technology has been built for highly supporting the patients. In order to fulfill the life supporting requirement, the “Miniaturized portable hemodialysis” device has been introduced which will be portable than the conventional ones.

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“…In an effort to improve both health outcomes and quality of life for those on HD, research groups, including ours, are working on technologies for portable, wearable, or implantable HD . Such devices would not only provide lifestyle benefits in the form of mobility and convenience, they could also improve treatment outcomes by enabling more frequent or continuous dialysis (keeping uremic toxin levels steady with consistent water‐, electrolyte‐, and acid/base‐balance) that more closely replicates a functioning kidney.…”

Section: Introductionmentioning

confidence: 99%

“…The best hope for a healthier future for ESRD patients, short of a replacement kidney, is the emergence of disruptive technologies in HD therapy. One example is the wearable artificial kidney, which has been developed for peritoneal dialysis (PD), and for HD using miniaturized pumps and controls along with a standard hemodialyzer cartridge. Notably, these wearable devices are still bulky, weighing as much as ten pounds, and have difficulty with microbubbles and clotting issues that plague clinical continuous renal replacement .…”

Section: Introductionmentioning

confidence: 99%

Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis

Hill

Walker

Salminen

et al. 2020

Adv Healthcare Materials

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Conventional hemodialysis (HD) uses floor‐standing instruments and bulky dialysis cartridges containing ≈2 m2 of 10 micrometer thick, tortuous‐path membranes. Portable and wearable HD systems can improve outcomes for patients with end‐stage renal disease by facilitating more frequent, longer dialysis at home, providing more physiological toxin clearance. Developing devices with these benefits requires highly efficient membranes to clear clinically relevant toxins in small formats. Here, the ability of ultrathin (<100 nm) silicon‐nitride‐based membranes to reduce the membrane area required to clear toxins by orders of magnitude is shown. Advanced fabrication methods are introduced that produce nanoporous silicon nitride membranes (NPN‐O) that are two times stronger than the original nanoporous nitride materials (NPN) and feature pore sizes appropriate for middle‐weight serum toxin removal. Single‐pass benchtop studies with NPN‐O (1.4 mm2) demonstrate the extraordinary clearance potential of these membranes (105 mL min−1 m−2), and their intrinsic hemocompatibility. Results of benchtop studies with nanomembranes, and 4 h dialysis of uremic rats, indicate that NPN‐O can reduce the membrane area required for hemodialysis by two orders of magnitude, suggesting the performance and robustness needed to enable small‐format hemodialysis, a milestone in the development of small‐format hemodialysis systems.

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In vitro trials of a wearable artificial kidney (WAK)

Abstract: The WAK that we developed can eliminate metabolites from spent dialysis fluid with mass rates that are sufficient to maintain stable, physiologically normal metabolite concentrations in patients' blood.

Cited by 6 publications

References 9 publications

Design and Development of the Novel Technology for the Treatment of Patients with the Acute and Chronic Renal Failure

Design and Development of the Novel Technology for the Treatment of Patients with the Acute and Chronic Renal Failure

Design of Mobile Hemodialysis Apparatus for Acute Renal Failure Patient's Self-Help and Treatment Adherence

Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis

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