In vitro transdermal delivery of therapeutic antibodies using maltose microneedles

Li, Guohua; Badkar, Advait; Nema, Sandeep; Kolli, Chandra Sekhar; Banga, Ajay K.

doi:10.1016/j.ijpharm.2008.10.008

Cited by 176 publications

(90 citation statements)

References 20 publications

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“…Reproduced with permission from Elsevier. [8] [26] Polylactic acid (PLA) [27] Polyvinyl acetate (PVA) [18] Thermoplastic starch [28] Stainless steel [29] Polyglycolic acid (PGA) [27] Alginic acid [18] Carboxymethylcellulose [30] Titanium 19 Polylactide-co-glycolic acid (PLGA) [27] Gantrez AN-139, a copolymer of methylvinylether and maleic anhydride (PMVE/MA) [18] Amylopectin [30] Mesoporous silicon [31] Polycarbonate [16] Carbopol 971 P-NF 18 Dextran, galactose, chondroitin sulfate [32] Polyvinylpyrrolidone (PVP) [33] Polyetherimide [34] Maltose [35] Microneedles: an emerging drug delivery Shital H. Bariya et al…”

Section: Materials Used To Constitute Microneedlesmentioning

confidence: 99%

“…Li et al developed microneedles for rapid delivery of monoclonal antibodies. [35] They covered the skin with cardboard and observed that microneedles dissolved in a minute and micro channels remained open for 24 h. BioserenTach developed dissolving microneedles that are under clinical trial. Dissolving microneedles are capable of delivering a small dose, less than several milligrams, of peptides, proteins, vaccines, hormones and organic compounds.…”

Section: Immunobiologicalsmentioning

confidence: 99%

“…Hepatitis B vaccine [61] Poke and release Antigenicity was maintained at high temperature. Human IgG [35] Poke and release Transportation of macromolecules through skin was enhanced. Anthrax, botulism, plague and staphylococcal toxins [62] Poke and flow To avoid physical and chemical incompatibility of such multiple/combination vaccine.…”

Section: Drugsmentioning

confidence: 99%

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Microneedles: an emerging transdermal drug delivery system

Bariya

Gohel

Mehta

et al. 2011

Journal of Pharmacy and Pharmacology

340

207

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Objectives One of the thrust areas in drug delivery research is transdermal drug delivery systems (TDDS) due to their characteristic advantages over oral and parenteral drug delivery systems. Researchers have focused their attention on the use of microneedles to overcome the barrier of the stratum corneum. Microneedles deliver the drug into the epidermis without disruption of nerve endings. Recent advances in the development of microneedles are discussed in this review for the benefit of young scientists and to promote research in the area. Key findings Microneedles are fabricated using a microelectromechanical system employing silicon, metals, polymers or polysaccharides. Solid coated microneedles can be used to pierce the superficial skin layer followed by delivery of the drug. Advances in microneedle research led to development of dissolvable/degradable and hollow microneedles to deliver drugs at a higher dose and to engineer drug release. Iontophoresis, sonophoresis and electrophoresis can be used to modify drug delivery when used in concern with hollow microneedles. Microneedles can be used to deliver macromolecules such as insulin, growth hormones, immunobiologicals, proteins and peptides. Microneedles containing 'cosmeceuticals' are currently available to treat acne, pigmentation, scars and wrinkles, as well as for skin tone improvement. Summary Literature survey and patents filled revealed that microneedle-based drug delivery system can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by conventional transdermal techniques.

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Section: Materials Used To Constitute Microneedlesmentioning

confidence: 99%

Section: Immunobiologicalsmentioning

confidence: 99%

See 1 more Smart Citation

Microneedles: an emerging transdermal drug delivery system

Bariya

Gohel

Mehta

et al. 2011

Journal of Pharmacy and Pharmacology

340

207

View full text Add to dashboard Cite

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“…Microneedles (MNs) are attractive medical devices for transdermal delivery for a wide range of active substances such as vaccines, proteins, anticancer drugs, oligonucleotides and DNA (Arora et al, 2008;Chabri et al, 2004;Katikaneni et al, 2009;Kim et al, 2014;Li et al, 2009;Lin et al, 2001). MNs facilitate the passing of therapeutic agents through the stratum corneum by creating micro-channels (Chen et al, 2012;Choi et al, 2012;Lee et al, 2008) by piercing the skin.…”

Section: Introductionmentioning

confidence: 99%

Inkjet printing of transdermal microneedles for the delivery of anticancer agents

Uddin

Scoutaris

Klepetsanis

et al. 2015

International Journal of Pharmaceutics

150

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A novel inkjet printing technology is introduced as a process to coat metal microneedle arrays with three anticancer agents 5-fluororacil, curcumin and cisplatin for transdermal delivery. The hydrophilic graft copolymer Soluplus® was used as a drug carrier and the coating formulations consisted of drug -polymer solutions at various ratios. A piezoelectric dispenser jetted microdroplets on the microneedle surface to develop uniform, accurate and reproducible coating layers without any material losses. Inkjet printing was found to depend on the nozzle size, the applied voltage (mV) and the duration of the pulse (s). The drug release rates were determined in vitro using Franz type diffusion cells with dermatomed porcine skin. The drug release rates depended on the drug-polymer ratio, the drug lipophilicity and the skin thickness. All drugs presented increased release profiles (750 m skin thickness), which were retarded for 900 m skin thickness. Soluplus assisted the drug release especially for the water insoluble curcumin and cisplatin due to its solubilizing capacity. Inkjet printing was proved an effective technology for coating of metal microneedles which can then be used for further transdermal drug delivery applications.

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“…Various approaches have been devised to improve the skin permeability to drugs. The current advances include microneedles [5][6][7][8], iontophoresis (electric current) [9,10], ultrasound [11][12][13], photomechanical waves [14], electroporation (transient high-voltage electrical pulses) [15,16] and pressurized air techniques [17,18].…”

Section: Introductionmentioning

confidence: 99%

Microwave: Effects and Implications in Transdermal Drug Delivery

Anuar¹,

Wong²

2013

PIER

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Abstract-This study investigated transdermal drug delivery mechanisms of pectin and pectin-oleic acid (OA) gels and their effects on skin barrier treated by microwave. Hydrophilic pectin-sulphanilamide gels, with or without OA penetration enhancer, were subjected to drug release and skin permeation studies. The skins were untreated or microwave-treated, and characterized by infrared spectroscopy, raman spectroscopy, thermal, electron microscopy and histology techniques. Unlike solid film, skin treatment by microwave at 2450 MHz demoted drug permeation especially from OA-rich pectin gel. The pectin-skin binding was facilitated by gel with freely soluble pectin molecules instead of solid film with entangled chains. It was promoted when microwave fluidized stratum corneum into structureless domains, or OA extracted endogenous lipid fraction and formed separate phases within intercellular lipid lamellae. This led to a remarkable decrease in transdermal drug permeation. Microwave-enhanced transdermal delivery must not be implemented with pectin gel. In skin treated by microwave, the penetration enhancer in gel can act as a permeation retardant.

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In vitro transdermal delivery of therapeutic antibodies using maltose microneedles

Cited by 176 publications

References 20 publications

Microneedles: an emerging transdermal drug delivery system

Microneedles: an emerging transdermal drug delivery system

Inkjet printing of transdermal microneedles for the delivery of anticancer agents

Microwave: Effects and Implications in Transdermal Drug Delivery

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