In vitro testing of an artificial muscle for the treatment of incontinence

Abstract

The burden of incontinence is profound, affecting individuals both physically and emotionally. Treatment pathways typically progress from conservative measures to surgical interventions, sometimes culminating in the implantation of artificial sphincters. The existing models including the AMS 800™ show high revision rates. Complications such as tissue erosion further underscore the need for innovation in this field. Here, we propose an approach utilizing Hydraulically Amplified Self-healing Electrostatic (HASEL) actuators to develop an advanced artificial urethral sphincter. By employing HASEL actuators arranged in a cuff configuration, we aim to address the limitations of current devices. Initial in vitro testing on porcine urethrae has shown promising results in controlling the water flow at a hydrostatic pressure of 20 cmH 2 O, demonstrating the feasibility to mimic sphincter function. This approach holds potential to significantly enhance the quality of life for patients suffering from incontinence as they regain control over their bodies. Further research and clinical trials are warranted to validate the efficacy and safety of this approach.