“In-Vitro” Testing of an Antacid Formulation with Prolonged Gastric Residence Time (Almagate Flot-Coat®)

Fábregas, Jaime; Claramunt, Juan; Cucala, J.; Pous, R.; Siles, A.

doi:10.3109/03639049409038361

Cited by 24 publications

(11 citation statements)

References 4 publications

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“…Companies investing in the development of gastroretentive drug delivery systems (Pies, 1982;Washington et al, 1986;Chouza et al, 1987;Erni & Held, 1987;Ceballos-Baumann et al, 1990;Degtiareva et al, 1994;Fabregas et al, 1994 (Rubinstein & Friend, 1994). Floatation can also achieve by the volatilization of an organic solvent (e.g.…”

Section: Effervescent Systemsmentioning

confidence: 97%

Decades of research in drug targeting to the upper gastrointestinal tract using gastroretention technologies: where do we stand?

Awasthi

Kulkarni

2014

Drug Delivery

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A major constraint in oral controlled release drug delivery is that not all the drug candidates are absorbed uniformly throughout the gastrointestinal tract (GIT). Drugs having "absorption window" are absorbed in a particular portion of GIT only or are absorbed to a different extent in various segments of the GIT. Thus, only the drug released in the region preceding and in close vicinity to the absorption window is available for absorption. The drug must be released from the dosage form in solution form; otherwise, it is generally not absorbed. Hence, much research has been dedicated to the development of gastroretentive drug delivery systems that may optimize the bioavailability and subsequent therapeutic efficacy of such drugs, as these systems have unique properties to bypass the gastric emptying process. These systems show excellent in vitro results but fail to give desirable in vivo performance. During the last 2-3 decades, researchers from the academia and industries are giving considerable importance in this field. Unfortunately, till date, few so-called gastroretentive dosage forms have been brought to the market in spite of numerous academic publications. The manuscript considers strategies that are commonly used in the development of gastroretentive drug delivery systems with a special attention on various parameters, which needs to be monitored during formulation development.

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Section: Effervescent Systemsmentioning

confidence: 97%

Decades of research in drug targeting to the upper gastrointestinal tract using gastroretention technologies: where do we stand?

Awasthi

Kulkarni

2014

Drug Delivery

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“…When raft-forming systems come into contact with gastric fluid, they swell and form a viscous cohesive gel leading to the formation of a continuous layer termed as rafts [17,62]. Fabregas et al [89] explained the antacid raft-forming floating system. The authors used sodium alginate as a gel-forming polymer, and sodium bicarbonate and acid neutralizer as gas-generating agents.…”

Section: Current Pharmaceutical Technologies Of Grddsmentioning

confidence: 99%

Current State and Future Perspectives on Gastroretentive Drug Delivery Systems

et al. 2019

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In recent years, many attempts have been made to enhance the drug bioavailability and therapeutic effectiveness of oral dosage forms. In this context, various gastroretentive drug delivery systems (GRDDS) have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. In this review, we discuss the physiological state of the stomach and various factors that affect GRDDS. Recently applied gastrointestinal technologies such as expandable, superporous hydrogel; bio/mucoadhesive, magnetic, ion-exchange resin; and low- and high-density-systems have also been examined along with their merits and demerits. The significance of in vitro and in vivo evaluation parameters of various GRDDS is summarized along with their applications. Moreover, future perspectives on this technology are discussed to minimize the gastric emptying rate in both the fasted and fed states. Overall, this review may inform and guide formulation scientists in designing the GRDDS.

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“…misoprostol , antacids (Fabregas et al, 1994) and antibiotics (Yang et al, 1999, Whitehead et al, 2000 drugs that are absorbed primarily in the stomach, e.g. metronidazole (Adebisi and Conway, 2010) drugs that are poorly soluble at alkaline pH, e.g.…”

Section: Gastroretentive Systemsmentioning

confidence: 99%

Gastroretentive microparticles for drug delivery applications

Adebisi

Conway

2011

Journal of Microencapsulation

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Many strategies have been proposed to explore the possibility of exploiting gastroretention for drug delivery. Such systems would be useful for local delivery, for drugs that are poorly soluble at higher pH or primarily absorbed from the proximal small intestine. Generally, the requirements of such strategies are that the vehicle maintains controlled drug release and exhibits prolonged residence time in the stomach. Despite widespread reporting of technologies, many have an inherent drawback of variability in transit times. Microparticulate systems, capable of distributing widely through the GI tract, can potentially minimize this variation. While being retained in the stomach, the drug content is released slowly at a desired rate,

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“In-Vitro” Testing of an Antacid Formulation with Prolonged Gastric Residence Time (Almagate Flot-Coat®)

Cited by 24 publications

References 4 publications

Decades of research in drug targeting to the upper gastrointestinal tract using gastroretention technologies: where do we stand?

Decades of research in drug targeting to the upper gastrointestinal tract using gastroretention technologies: where do we stand?

Current State and Future Perspectives on Gastroretentive Drug Delivery Systems

Gastroretentive microparticles for drug delivery applications

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