In vitro test of phagocytic ability of human platelets using colloidal carbon.

Endo, Eiko; Fujimoto, H.; Ishimori, Akira; Matsuura, Noboru; Khato, Juneji; Takahashi, Tohru

doi:10.1620/tjem.142.131

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For evaluation of hemostatic function, prothrombin time (PT) (Quick 1935), partial thromboplastin time (PTT) (Langdell et al 1953), thrombin time (Dacie and Lewis 1970), thrombotest (Owren 1959), fibrinogen (Clauss 1957) and platelet counts were examined (Endo et al 1984). Plasminogen (Friberger et al 1978), o2-plasmin inhibitor (Friberger et al 1978), and antithrombin III (Blomback et al 1974), were also investigated.…”

Section: Items Examinedmentioning

confidence: 99%

Liver transplantation in dogs after 30 minutes of warm ischemia.

Ohkohchi

Sasaki

Namiki

et al. 1986

Tohoku J. Exp. Med.

Self Cite

View full text Add to dashboard Cite

In order to investigate the applicability of liver transplantation after warm Ischemia, a partial auxiliary auto-transplantation of the liver after 30 min of warm Ischemia was carried out in 9 mongrel dogs. Among them, 6 dogs survived longer than 7 days. Liver functions, blood coagulability and histological changes were investigated before and after the transplantation. Serum GOT, LDH, and OPT levels were elevated immediately after transplantation, and returned to normal within a few days. Hemostatic tests also showed significant abnormalities after transplantation. Although PT and thrombotest became normal within a week, PTT and antithrombin III remained slightly abnormal for longer periods. Microscopically, vacuolization and degeneration of hepatocytes were observed after transplantation but they recovered completely within 4 weeks. Based on these results, it could be said that the livers subjected to warm ischemia for 30 min ischemia were still acceptable for auxiliary transplantation.liver transplantation ; liver function test ; hemostatic test Recently, liver transplantation has been carried out in many countries (Starzl et al. 1982;Mac Dougall and Williams 1983: Pichlmayr et al. 1983;Bismuth and Houssin 1984), and its indications have been expanded. In liver transplantation, massive hemorrhaging due to abnormal blood coagulation, in addition to hepatic dysfunction, is very troublesome. Actually more than 50 liter of whole blood, a large amount of platelets and fresh frozen plasma are often required during an operation. When the liver is removed from the donor, warm ischemia and consequent damage of the liver may occur as results of a decreased blood pressure or heart failure during the removal. As a rule, a liver with warm ischemia is thought to be not acceptable for transplantation (Starzl et al. 1964). However, if these livers are transplantable, the number of donors would increase greatly.

show abstract