In vitro techniques to evaluate buccal films

Nair, Anroop B.; Kumria, Rachna; Harsha, Sree; Attimarad, Mahesh; Al‐Dhubiab, Bandar E.; Alhaider, Ibrahim A.

doi:10.1016/j.jconrel.2012.11.019

Cited by 251 publications

(206 citation statements)

References 73 publications

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“…For every time point, the medium was carefully removed to obtain an accurate weight of the sample and replaced with fresh medium. Three replicates were performed for each sample and swelling index (%) was calculated using equation 5 [23].…”

Section: Swelling Studiesmentioning

confidence: 99%

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Okeke

Boateng

2016

International Journal of Biological Macromolecules

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Smoking cessation is of current topical interest due to the significant negative health and economic impact in many countries. This study aimed to develop buccal films and wafers comprising HPMC and sodium alginate (SA) for potential use in nicotine replacement therapy via the buccal mucosa, as a cheap but effective alternative to currently used nicotine patch and chewing gum. The formulations were characterised using texture analyser (tensile and hardness, mucoadhesion), scanning electron microscopy, x-ray diffractometry, attenuated total reflection -Fourier transform infrared (ATR-FTIR), differential scanning calorimetry (DSC) and swelling capacity. Drug loaded films and wafers were characterised for content uniformity (HPLC) whilst the drug loaded wafers only were further characterised for in vitro drug dissolution. SA modified and improved the functional properties of HPMC at optimum ratio of HPMC: SA of 1.25 : 0.75. Generally, both films and wafers (blank and drug loaded) were amorphous in nature which impacted on swelling and mucoadhesive performance.HPMC-SA composite wafers showed a porous internal morphology with higher mucoadhesion, swelling index and drug loading capacity compared to the HPMC-SA composite films which were non-porous. The study demonstrates the potential use of composite HPMC-SA wafers in the buccal delivery nicotine.

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Section: Swelling Studiesmentioning

confidence: 99%

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Okeke

Boateng

2016

International Journal of Biological Macromolecules

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“…The release exponents of MAS loaded formulations of less than 535 0.45 was outside the limits of Korsmeyer-Peppas model and also highlights the 536 limitations of the Korsmeyer-Peppas model in the understanding of drug release 537 mechanisms (Shoaib, Tazeen, Merchant, & Yousuf, 2006). However, the release 538 exponent of 0.48 for wafers without MAS (MAS 0.00 wafers) shows that drug release 539 from these wafers followed a Fickian diffusion transport mechanism (Nair et al, 2013). 540…”

Section: Drug Release Kinetics 444mentioning

confidence: 99%

Nicotine stabilization in composite sodium alginate based wafers and films for nicotine replacement therapy

Okeke

Boateng

2017

Carbohydrate Polymers

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“…The thickness was measured at six different locations. 18 Folding endurance was measured by folding films (4х4 cm²) at same location repeatedly making an angle of 180° till it breaks. For pH determination, film of size of 1х1 cm² was taken and dipped in water (5 mL) for 30 minutes.…”

Section: Evaluation Of Filmsmentioning

confidence: 99%

Mucoadhesive Film Embedded with Acyclovir Loaded Biopolymeric Nanoparticles: In vitro Studies

Nair¹,

Al-ghannam²,

Al‐Dhubiab³

et al. 2017

JYP

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Objective: The efficiency of acyclovir, a potent antiviral agent, is mainly limited by its low permeability.The purpose of this investigation was to formulate and assess nanoparticle impregnated buccal films to improve acyclovir permeability and thereby enhance bioavailability. Methods: Acyclovir was incorporated into the polymeric materials and formulated as nanoparticles. The prepared nanoparticles were then loaded into various films (F5-F7) prepared with varying quantities of hydroxyethyl cellulose and Eudragit RL 100. The prepared films were evaluated for physico-mechanical characters, mucoadhesion, swelling, in vitro acyclovir release and ex vivo diffusion. Results: The films so prepared showed adequate mucoadhesive strength and excellent physico-mechanical properties. Rapid hydration of films (>35%) were observed in 15 min, followed by a relatively slower phase of hydration which continued till 60 min. In vitro release profile exhibited biphasic pattern, while the rate of acyclovir release was higher with film F7. Prepared films exhibited either first order (F5, control) or Higuchi model (F6, F7) kinetics. The enhancement in acyclovir permeation in F5, F6 and F7 loaded films were 2.2, 4.1 and 6.7 folds, respectively, when compared to control. Conclusion: This study concludes that the drug loaded nanoparticles impregnated buccal film could be an alternative approach to enhance the oral bioavailability of acyclovir, and need to be proved in vivo.

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In vitro techniques to evaluate buccal films

Cited by 251 publications

References 73 publications

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Nicotine stabilization in composite sodium alginate based wafers and films for nicotine replacement therapy

Mucoadhesive Film Embedded with Acyclovir Loaded Biopolymeric Nanoparticles: In vitro Studies

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