In Vitro Synergistic Photodynamic, Photothermal, Chemodynamic, and Starvation Therapy Performance of Chlorin e6 Immobilized, Polydopamine-Coated Hollow, Porous Ceria-Based, Hypoxia-Tolerant Nanozymes Carrying a Cascade System
Çağıl Zeynep Süngü Akdogan,
Esin Akbay Çetin,
Mehmet Ali Onur
et al.
Abstract:A synergistic therapy agent (STA) with photothermal, photodynamic, chemodynamic, and starvation therapy (PTT, PDT, CDT, and ST) functions was developed. Hollow, mesoporous, and nearly uniform CeO 2 nanoparticles (H-CeO 2 NPs) were synthesized using a staged shape templating sol−gel protocol. Chlorin e6 (Ce6) was adsorbed onto H-CeO 2 NPs, and a thin polydopamine (PDA) layer was formed on Ce6-adsorbed H-CeO 2 NPs. Glucose oxidase (GOx) was bound onto PDA-coated Ce6-adsorbed H-CeO 2 NPs to obtain the targeted ST… Show more
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