In Vitro Susceptibilities of Candida albicans Isolates to Antifungal Agents in Tokat, Turkey

Yenişehirli, Gülgün; Bulut, Nermin; Yenişehirli, Aydan; Bulut, Yunus Emre

doi:10.5812/jjm.28057

Cited by 33 publications

(33 citation statements)

References 39 publications

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“…The resistance rate of voriconazole in the present study was 3.8% (6.5% intermediate), and in other studies, it was reported to be 2.3% [5], 6% [3, 19], and 14% [9]. …”

Section: Discussionsupporting

confidence: 71%

Susceptibility pattern of Candida albicans isolated from Iranian patients to antifungal agents

et al. 2016

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Background and Purpose:Candidiasis is a major fungal infection, and Candida albicans is the major cause of infections in humans. The Clinical and Laboratory Standards Institute (CLSI) developed new breakpoints for antifungal agents against C. albicans. In this multi-center study, we aimed to determine the drug susceptibility profile of C. albicans, isolated from Iranian population according to new species-specific CLSI.Materials and Methods:Clinical samples were cultured on Sabouraud dextrose agar and were incubated at room temperature for seven days. The isolates were transferred to Professor Alborzi Clinical Microbiology Research Center, Shiraz, Iran. C. albicans were identified by using API 20C AUX system. Broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of amphotericin B, caspofungin, voriconazole, fluconazole, posaconazole, itraconazole, and ketoconazole, based on CLSI document M27-S4 and new breakpoints for some azoles and caspofungin.Results:Overall, 397 C. albicans were isolated from patients admitted to ten university hospitals in Iran. The MIC90 of the isolates to amphotericin B, caspofungin, voriconazole, fluconazole, posaconazole, itraconazole, and ketoconazole were 0.125, 0.125, 0.125, 1, 0.064, 0.5, and 0.125 µg/ml, and rates of resistance were 0.5%, 0.3%, 3.8%, 2.8%, and 2.5% for amphotericin B, caspofungin, voriconazole, fluconazole, and itraconazole, respectively.Conclusion:According to our data, fluconazole is the drug of choice for management of patients at risk for systemic candidiasis throughout the region, since it is cost-effective with low side effects.

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“…The resistance rate of voriconazole in the present study was 3.8% (6.5% intermediate), and in other studies, it was reported to be 2.3% [5], 6% [3, 19], and 14% [9]. …”

Section: Discussionsupporting

confidence: 71%

Susceptibility pattern of Candida albicans isolated from Iranian patients to antifungal agents

et al. 2016

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“…On the other hand, the caspofungin resistance rate for C. krusei was documented as 12.5% in a multi-center study by Pfaller et al (25). Similarly, some studies reported that the MIC values of echinocandins were higher for C. parapsilosis strains (26,27). In our study, the caspofungin susceptibility rate was 97.5% and resistance was found in only one (2.5%) C. parapsilosis isolate.…”

Section: Discussionsupporting

confidence: 39%

Evaluation of Candida species and antifungal susceptibilities among children with invasive candidiasis

et al. 2017

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Aim: Non-albicans Candida species and resistant microorganisms have been more commonly isolated in invasive candidiasis in recent years. The aim of this study was to evaluate the distrubution of Candida spp and antifungal resistance in our clinic. Material and Methods: Fifty-four Candida isolates and antifungal susceptibility results obtained from patients diagnosed as having invasive candidiasis between December 2012 and June 2016 were included. Clinical and laboratory data were retrospectively analyzed. E-test method was used in order to determine antifungal susceptibilities of Candida spp for amphotericin B, fluconazole, voriconazole, ketoconazole, itraconazole, anidulafungin, caspofungin, and flucytosine. Results: The clinical diagnoses of the patients were candidemia (n=27, 50%), catheter-related blood stream infection (n=1, 1.8%), urinary tract infection (n=13, 24%), surgical site infection (n=4, 7.4%), intraabdominal infection (n=3, 5.5%), empyema (n=2, 3.7%), and pneumonia (n=4, 7.4%). The most common isolated agent was C. albicans (n=27, 50%) and the others were C. parapsilosis (n=13, 24%), C. tropicalis (n=6, 11.1%), C. glabrata (n=3, 5.6%), C. lusitaniae (n=2, 3.7%), and unspecified Candida spp. (n=3, 5.6%). Fluconazole resistance was 7.4% among all isolates. Resistance against itraconazole, ketoconazole, anidulafungin, voriconazole and caspofungin were 33.3%, 12.5%, 11.1%, 5%, and 2.5%, respectively. Isolates presented intermediate resistance against itraconazole (41.7%), voriconazole (5.6%), and amphotericin B (3.7%) to varying extents. All of the isolates were susceptible to flucytosine. Conclusions: In our clinic, C. albicans and non-albicans Candida species were equally distributed and antifungal susceptibilities against major antifungal agents such as fluconazole, amphotericin B, and caspofungin were found considerably high.

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“…The Candida albicans showed sensitivity to Amphotericin B, Fluconazole, Voriconazole. 9 This study bears a good correlation with our study.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of Vitek 2 System for Clinical Identification of Candida Species and Their Antifungal Susceptibility Test

Maruthamuthu¹,

Navaneethakrishnan²

2016

jemds

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In Vitro Susceptibilities of Candida albicans Isolates to Antifungal Agents in Tokat, Turkey

Cited by 33 publications

References 39 publications

Susceptibility pattern of Candida albicans isolated from Iranian patients to antifungal agents

Susceptibility pattern of Candida albicans isolated from Iranian patients to antifungal agents

Evaluation of Candida species and antifungal susceptibilities among children with invasive candidiasis

Evaluation of Vitek 2 System for Clinical Identification of Candida Species and Their Antifungal Susceptibility Test

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