In vitro Study on the Effect of Nanoparticles and Transfersomes as Targeted Drug Carrier for Cancer

Abstract

Introduction: Cancer is one of the current leading cause of death all over the world. Among the various emerging technologies, nanotechnology plays a prominent role in delivering the drug to the target region. Materials and Methods: In this study, the In vitro effect of doxorubicin adsorbed gold nanoparticles synthesized by Azadirachta Indica leaves extract as reducing agent and the doxorubicin entrapped modified liposomes called transfersomes was compared over the cervical cancer cell line (HeLa cell lines). The synthesized gold nanoparticles were characterized using a UV-visible spectrophotometer, SEM analysis. Results: The UV-Visible spectrum showed the peak at 537nm and the incorporation of drug over the nanoparticles was conformed using FTIR and SEM analysis. The drug entrapment onto transfersomes was also characterized using FTIR and SEM analysis. When compared, the drug entrapped transfersomes shows significant effect with the lowest concentration of drug (0.25 µg/mL) than the drug adsorbed nanoparticles. Conclusion: Hence, the transfersomes may also become the promising drug carrier in the future.