In vitro study of the interaction of Tilia europeae L. aqueous extract with GABAA receptors in rat brain

Screening of plants used in Danish folk medicine to treat epilepsy and convulsions

“…by reaction with antibodies (Medina et al, 1989). In the present study, the aqueous extract of Tilia europaea was inactive, but the ethanolic extract displaced the ligand at the same concentration as the aqueous extract in the study by Cavadas et al (1997). It has previously been shown that an aqueous extract of Tilia europaea possessed a sedative effect in mice (Coleta et al, 2001), indicating that the active compound(s) pass the blood-brain barrier.…”

“…An aqueous extract (10 mg/ml) of Tilia europaea could displace[ 3 H]flunitrazepam from the benzodiazepine site on the GABA A receptor (Cavadas et al, 1997). It was suggested that Tilia europaea contains an inhibitory compound(s) probably of a benzodiazepine-like nature, as such compounds have been detected in Tilia spp.…”

Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: Possible involvement of adenosine

“…It has been reported that GABA content of aqueous extracts of valerian is involved in the displacement of [ 3 H] muscimol binding, a selective GABA A receptor agonist (Cavadas et al, 1995). However, GABA does not cross blood-brain barrier (Rosenstein, 1996) and cannot account for the presumed pharmacological effects of valerian extracts.…”

Valerian Extract Ze 911 Inhibits Postsynaptic Potentials by Activation of Adenosine A1 Receptors in Rat Cortical Neurons

“…Interactions of valerians with other receptor subtypes, e. g., GA-BA A receptors [24], [25], [26] or 5-HT 5A receptors have been reported [27].…”