In vitro study of a glucose attached poly(aryl ether) dendron based gel as a drug carrier for a local anaesthetic

Kannan, Ramya; Muthuvijayan, Vignesh; Prasad, Edamana

doi:10.1039/c7nj01420a

Cited by 16 publications

(13 citation statements)

References 60 publications

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“…Synthesis of a thiolated hyaluronic acid copolymer for drug delivery, EDCI: 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride, NHS: N-hydroxysuccinimide [137], n represents the number of repeating units. Kannan et al researched the use of a carbohydrate-based low molecular weight gelator 30a (Figure 21) as a drug carrier for a local anesthetic [64]. Compound 30a was found to be capable of entrapping hydrophilic dyes and prilocaine hydrochloride, a local anesthetic drug.…”

Section: Drug Deliverymentioning

confidence: 99%

“…Kannan et al designed and synthesized poly aryl ether and poly alkyl ether glucose cored dendron-based LMWGs ( Figure 21 ) [ 64 ]. The results showed that there is a high tendency for the poly aryl ether dendrons to form strong gel system.…”

Section: Structure and Gelation Properties Of Monosaccharide Derivmentioning

confidence: 99%

“…Kannan et al researched the use of a carbohydrate-based low molecular weight gelator 30a ( Figure 21 ) as a drug carrier for a local anesthetic [ 64 ]. Compound 30a was found to be capable of entrapping hydrophilic dyes and prilocaine hydrochloride, a local anesthetic drug.…”

Section: Applications Of Sugar-based Lmwgsmentioning

confidence: 99%

See 2 more Smart Citations

Recently Developed Carbohydrate Based Gelators and Their Applications

Morris

Bietsch

Bashaw

et al. 2021

Gels

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Carbohydrate based low molecular weight gelators have been an intense subject of study over the past decade. The self-assembling systems built from natural products have high significance as biocompatible materials and renewable resources. The versatile structures available from naturally existing monosaccharides have enriched the molecular libraries that can be used for the construction of gelators. The bottom-up strategy in designing low molecular weight gelators (LMWGs) for a variety of applications has been adopted by many researchers. Rational design, along with some serendipitous discoveries, has resulted in multiple classes of molecular gelators. This review covers the literature from 2017–2020 on monosaccharide based gelators, including common hexoses, pentoses, along with some disaccharides and their derivatives. The structure-based design and structure to gelation property relationships are reviewed first, followed by stimuli-responsive gelators. The last section focuses on the applications of the sugar based gelators, including their utilization in environmental remediation, ion sensing, catalysis, drug delivery and 3D-printing. We will also review the available LMWGs and their structure correlations to the desired properties for different applications. This review aims at elucidating the design principles and structural features that are pertinent to various applications and hope to provide certain guidelines for researchers that are working at the interface of chemistry, biochemistry, and materials science.

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Section: Drug Deliverymentioning

confidence: 99%

Section: Structure and Gelation Properties Of Monosaccharide Derivmentioning

confidence: 99%

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Recently Developed Carbohydrate Based Gelators and Their Applications

Morris

Bietsch

Bashaw

et al. 2021

Gels

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show abstract

“…Marcos et al formulated a poloxamer-hydroxyethyl cellulose-α-cyclodextrin supramolecular gel in water, which sustained a release of the anti-fungal drug griseofulvin for at least three weeks and demonstrated biocompatibility [99]. To deliver a local anesthetic, prilocaine hydrochloride was loaded into a poly(aryl ether) dendron-based gel in DMSO-water solutions by Kannan et al for localized, sustained release [100].…”

Section: Supramolecular Gels For Biomedical Applicationsmentioning

confidence: 99%

Beyond Covalent Crosslinks: Applications of Supramolecular Gels

Christoff‐Tempesta

Lew

Ortony

2018

Gels

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Traditionally, gels have been defined by their covalently cross-linked polymer networks. Supramolecular gels challenge this framework by relying on non-covalent interactions for self-organization into hierarchical structures. This class of materials offers a variety of novel and exciting potential applications. This review draws together recent advances in supramolecular gels with an emphasis on their proposed uses as optoelectronic, energy, biomedical, and biological materials. Additional special topics reviewed include environmental remediation, participation in synthesis procedures, and other industrial uses. The examples presented here demonstrate unique benefits of supramolecular gels, including tunability, processability, and self-healing capability, enabling a new approach to solve engineering challenges.

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“…Glucose derived poly(arylether) dendritic molecules ( 39a–c , Figure 28), exhibit gelation ability; 39b and 39c congeal DMSO and 39a gels in aqueous DMSO (1:1) [122]. The gels have been characterized by SEM, TEM, and PXRD of the xerogel, and also by rheological experiments.…”

Section: Applicationsmentioning

confidence: 99%

Carbohydrate Derived Organogelators and the Corresponding Functional Gels Developed in Recent Time

Basu¹,

Chakraborty

Ghosh

2018

Gels

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Owing to their multifarious applicability, studies of molecular and supramolecular gelators and their corresponding gels have gained momentum, particularly in the last two decades. Hydrophobic-hydrophilic balance, different solvent parameters, gelator-gelator and gelator-solvent interactions, including different noncovalent intermolecular interactive forces like H-bonding, ionic interactions, π-π interactions, van der Waals interactions, etc., cause the supramolecular gel assembly of micro and nano scales with different types of morphologies, depending on the gelator, solvent, and condition of gelation. These gel structures can be utilized for making template inorganic superstructures for potential application in separation, generation of nanocomposite materials, and other applications like self-healing, controlled drug encapsulation, release and delivery, as structuring agents, oil-spill recovery, for preparation of semi-conducting fabrics, and in many other fields. Sugars, being easily available, inexpensive, and nontoxic natural resources with multi functionality and well-defined chirality are attractive starting materials for the preparation of sugar-based gelators. This review will focus on compilation of sugar derived organogelators and the corresponding gels, along with the potential applications that have been

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In vitro study of a glucose attached poly(aryl ether) dendron based gel as a drug carrier for a local anaesthetic

Abstract: A poly(aryl ether) dendron based gelator as an efficient transdermal drug carrier for the controlled release of prilocaine hydrochloride.

Cited by 16 publications

References 60 publications

Recently Developed Carbohydrate Based Gelators and Their Applications

Recently Developed Carbohydrate Based Gelators and Their Applications

Beyond Covalent Crosslinks: Applications of Supramolecular Gels

Carbohydrate Derived Organogelators and the Corresponding Functional Gels Developed in Recent Time

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