In-vitro study for Ibuprofen encapsulation, controlled release and cytotoxicity improvement using excipient-drugs mixed micelle

Counterion Association of Ionic Drugs with Sodium Tetradecyl Sulfate in the Aqueous Medium

“…As indicated in Table , the concentrations of CAC dropped as the concentration of DPC increased in the micellar medium. We previously reported that the CMC of DPC was 92.2 mmol L –1 and CPM was 66.8 mmol L –1 in water, , and that at lower concentrations of STS molecules, monomeric interactions between STS-DPC and STS-CPM were discovered, with the first break occurring. The CMC of STS was thought to be the second or most prominent break in the conductance graphs.…”

“…Therefore, it was chosen that the fitted value of N m was approximately equivalent to 1, and the absorbance data showed that one drug was bound to each micelle. Other studies have already reported on the variance of N m values. ,,,,,,, For instance, Caetano and Tabak used a relation similar to eq to analyze the absorbance data of the drugs trifluoperazine and chlorpromazine in aqueous cetyltrimethylammonium chloride solution, resulting in found values of N m in the variety of 0.90–1.14 for chlorpromazine and in the range of 1.00–1.12 for trifluoperazine. Pellosi et al reported values of N m around 1 for the four xanthenes dyes fluorescein, eosin Y, erythrosin B, and rose bengal B in an aqueous pluronic P-123 solution, however, they observed values of N m close to 2 in an aqueous cetyltrimethylammonium bromide solution.…”

“…Other studies have already reported on the variance of N m values. 13,14,19,28,29,32,40,41 For instance, Caetano and Tabak 45 Furthermore, the K b value was determined using the slope and intercept data from Figure 8. For DPC and CPM, the values of log K b were 2.232 and 2.837, respectively.…”

Comparative studies on the aggregate formation of synthesized zwitterionic gemini and monomeric surfactants in the presence of the amphiphilic antipsychotic drug chlorpromazine hydrochloride in aqueous solution: an experimental and theoretical approach

“…20 In the pharmaceutical field, mixed micelles have been shown to enhance the absorption of various water-insoluble drugs in the human body, as mixed micelle systems have been used as effective drug carriers. [21][22][23][24][25] Most drugs commonly used as local anesthetics, antidepressants, sedatives, and antibiotics are amphiphilic, like conventional surfactants, and can form micellar aggregates in water with an aggregation number of 8-10. 26 The pharmacological activity of these drugs requires a concentration well below their cmcs, 27 which are measured in vitro with a negligible number of drug monomers in the aggregated units.…”

Binding and occupancy properties of gabapentin in mixed surfactant systems

“…These synergistic effects include increased wetting, detergency, solubilization, and surface activity. In equilibrium with the surfactant monomers, mixed micellar aggregates are made up of two or more distinct surfactants (Azum et al, 2019; Azum et al, 2023; Kumar et al, 2022; Kumar, Raj, et al, 2021; Kumar, Singh, et al, 2021; Mahajan & Mahajan, 2012; Srivastava et al, 2015; Srivastava, Liu, et al, 2018; Srivastava, Qiao, & Ismail, 2018; Srivastava, Thapa, et al, 2019; Srivastava, Uchiyama, et al, 2019; Uchiyama et al, 2018; Vashishat et al, 2015).…”