In Vitro Study for Effects of Estrogen on Estrogen Receptor-Transfected Neuroblastoma Cells

Agrati, Paola; Bolzoni, Laura; Brusadelli, Alessia; Ciana, Paolo; Marini, Elena; Meda, Clara; Patrone, Cesare; Penlington, Michael; Pollio, Giuseppe; Rebecchi, Monica; Sialino, Rodolfo; Vegeto, Elisabetta; Maggi, Adriana

doi:10.1201/9781439832288.ch3

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“…In addition, recent, unpublished results from our laboratory, show that ERs are present also in rat microglial cells (Vegeto et al, unpublished data). Interestingly, localization studies indicate that ERa and b are generally expressed in different areas of the CNS [41,42,3]. It is conceivable, therefore, that in each specific target cell the estrogen triggers differential responses by activating selected target genes.…”

Section: All Neural Cell Types May Be Target For Estrogen Acti6itymentioning

confidence: 99%

Identification of estrogen target genes in human neural cells

Maggi

Vegeto

Brusadelli

et al. 2000

The Journal of Steroid Biochemistry and Molecular Biology

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In mammals, estrogens have a multiplicity of effects ranging from control of differentiation of selected brain nuclei, reproductive functions, sexual behavior. In addition, these hormones influence the manifestation of disorders like depression and Alzheimer's. Study of the cells target for the hormone has shown that estrogen receptors (ERs) are expressed in all known neural cells, including microglia. In view of the potential interest in the use of estrogens in the therapy of several pathologies of the nervous system, it would be of interest to fully understand the mechanism of estrogen activity in the various neural target cells and get an insight on the molecular means allowing the hormone to display such a variety of effects. We have proposed the use of a reductionist approach for the systematic understanding of the estrogen activities in each specific type of target cell. Thus, we have generated a model system in which to study the activation of one of the known (ERs), estrogen receptor alpha. This system allowed us to identify a number of novel genes which expression may be influenced following the activation of this receptor subtype by estradiol (E(2)). We here report on data recently obtained by the study of one of these target genes, nip2, which encodes a proapoptotic protein product. We hypothesize that nip2 might be an important molecular determinant for estrogen anti-apoptotic activity in cells of neural origin and represents a potential target for drugs aimed at mimicking the E(2) beneficial effects in neural cells.

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Section: All Neural Cell Types May Be Target For Estrogen Acti6itymentioning

confidence: 99%