In Vitro Study: Effect of Cobalt(II) Chloride Against Dengue Virus Type 1 in Vero Cells

Abstract

Dengue virus (DENV) serotypes possess various types from DENV-1 to DENV-4 that are enveloped viruses belong to the genus Flavivirus of the Flaviviridae. Dengue vaccine or antiviral has not yet been clinically approved for humans, even though there have been significant efforts toward this end. Antiviral activity against DENV is needed to develop to be an alternative drug for the DENV virus. Cobalt(II) chloride has been used in the treatment and prevention of diseases of humans since ancient times. This study aimed to investigate the antiviral effects and Cytotoxicity of Cobalt(II) chloride. This compound was further investigated for its inhibitory effect on the replication of DENV-1 in Vero cells. The antiviral activity and cytotoxic was measured by WST-1 assay. The IC50 value of the Cobalt(II) chloride for DENV-1 was 0.38 μg/ml. The cytotoxicity of Cobalt(II) chloride to Vero cell suggests that the CC50 value was 2.91 µg/ml. The results of this study demonstrate the anti-dengue serotype 1 inhibitory activity of Cobalt(II) chloride was highly toxic.

Amine-Functionalized Silver Nanoparticles: A Potential Antiviral-Coating Material with Trap and Kill Efficiency to Combat Viral Dissemination (COVID-19)

“…Metal nanoparticles and oxides have been widely explored for antiviral therapy over the last few decades with the development of surface functionalization strategies [83]. In recent studies, Ag, Au, TiO 2 , SiO 2 , CeO 2 , and CuCl 2 nanoparticles have been evaluated for their antiviral activity against different viruses, including hepatitis B virus (HBV), H3N2 and H1N1, HIV-1, herpes simplex virus (HSV), vesicular stomatitis, foot-and-mouth disease, and dengue virus type-2 [55,[84][85][86][87][88][89][90][91].…”