Epidemiology and Biology of Multiple Myeloma 1991
DOI: 10.1007/978-3-642-76655-8_20
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In Vitro Studies Provide Evidence that Multiple Paracrine Loops may be Operating in Multiple Myeloma

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“…It is noteworthy that a number of similarities can be found between the above murine studies and analyses of human multiple myeloma. Human myeloma lines have proven difficult to establish, but, in a number of instances, such lines have been obtained using conditioned medium (24,25), skin fibroblasts (26,27), bone marrow-derived stromal cells (28)(29)(30)(31), or IL-6 (28)(29)(30)(31)(32). In some cases, these lines appear to "progress" from stromal cell dependence, to soluble factor dependence, to autonomous growth in much the same way as murine plasmacytomas.…”
Section: Resultsmentioning
confidence: 99%
“…It is noteworthy that a number of similarities can be found between the above murine studies and analyses of human multiple myeloma. Human myeloma lines have proven difficult to establish, but, in a number of instances, such lines have been obtained using conditioned medium (24,25), skin fibroblasts (26,27), bone marrow-derived stromal cells (28)(29)(30)(31), or IL-6 (28)(29)(30)(31)(32). In some cases, these lines appear to "progress" from stromal cell dependence, to soluble factor dependence, to autonomous growth in much the same way as murine plasmacytomas.…”
Section: Resultsmentioning
confidence: 99%