In Vitro Studies on Hemodynamics of Type B Aortic Dissection: Accuracy and Reliability

Abstract

Type B aortic dissection (TBAD) is associated with high mortality. Multiple in vitro models and computational fluid dynamics (CFD) simulations have been used to mimic the hemodynamic characteristics of TBAD to inform more effective therapeutic strategies. However, the results of these experiments are rarely used in clinical practice due to concerns about their accuracy and reliability. The development of 4-dimensional magnetic resonance imaging (4D-MRI) allows to verify the accuracy of the results of in vitro models and CFD simulations. This review provides an overview of the strengths, limitations, and accuracy of in vitro models, CFD simulations, and in vivo 4D flow MRI for the study of TBAD hemodynamics. Clinical Impact 1. Hemodynamic of TBAD is important to improve the long-term outcome of TEVAR. 2. This review provides an overview of the in-vitro for the hemodynamic study of TBAD. 3. The accuracy and validity of in-vitro TBAD experiments should be further studied.