In vitro studies of local blood flow disturbance in a region of separation

Gutstein, William H.; Schneck, Daniel J.; Marks, J.O.

doi:10.1016/s0368-1319(68)80095-x

Cited by 59 publications

(11 citation statements)

References 3 publications

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“…1 ' 2 This finding led to the hypothesis that hemodynamic factors are in some way involved in atherogenesis, although the precise nature of the flow or pressure changes favoring atherogenesis is not yet well understood. In humans, one of the most common sites for localization of atherosclerosis is at the carotid bifurcation, especially at the origin of the internal carotid artery where it may be the cause of transient ischemic attacks or stroke.…”

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confidence: 99%

Flow studies in a model carotid bifurcation.

LoGerfo¹,

Nowak²,

Quist³

et al. 1981

Arteriosclerosis

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Boundary layer separation in a plexiglass model carotid bifurcation was investigated in relation to the origin of atherosclerotic plaque clinically found in this region. Our model was comparable to a human carotid in both dimensions and geometry. T he predilection for atherosclerosis to occur at bifurcations in the arterial tree is well documented. 1 ' 2 This finding led to the hypothesis that hemodynamic factors are in some way involved in atherogenesis, although the precise nature of the flow or pressure changes favoring atherogenesis is not yet well understood. In humans, one of the most common sites for localization of atherosclerosis is at the carotid bifurcation, especially at the origin of the internal carotid artery where it may be the cause of transient ischemic attacks or stroke. model of the human carotid bifurcation based on averaged data from angiographic measurements. The flow field within this bifurcation model was studied with the laser Doppler anemometer under steady flow conditions, and velocity profiles across the bifurcation determined. 8 This work demonstrated a large region of flow separation and low wall shear stress at the origin of the internal carotid. In previous work from this laboratory, we have demonstrated the three-dimensional nature of separation and secondary flow in model anastomoses and bifurcations. 910The Balasubramanian model does not incorporate the curvature of vessels that is seen on arteriography. We have taken the internal measurements from Balasubramanian's model and have superimposed on that the curvature of vessels seen in the arteriogram of a carotid artery with atherosclerotic plaque present at the bifurcation (figure 1). This model is, therefore, a very close approximation of the carotid bifurcation seen in figure 1 prior to the formation of the atherosclerotic plaque. This allows us to demonstrate the flow field under steady and pulsatile flow conditions. The relevance of these studies to the formation of atherosclerotic plaque is also discussed.

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confidence: 99%

Flow studies in a model carotid bifurcation.

LoGerfo¹,

Nowak²,

Quist³

et al. 1981

Arteriosclerosis

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“…BLS has been shown to predispose patients to atherosclerosis at arterial bifurcations [20]. LoGerfo also suggested that BLS is an important factor in the localization and progression of the atherosclerosis rather than an initiator of the disease [6].…”

Section: Discussionmentioning

confidence: 99%

Blunt trauma to large vessels: a mathematical study

Ismailov

Shevchuk²,

Schwerha

et al. 2004

BioMed Eng OnLine

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Background: Blunt trauma causes short-term compression of some or all parts of the chest, abdomen or pelvis and changes hemodynamics of the blood. Short-term compression caused by trauma also results in a short-term decrease in the diameter of blood vessels. It has been shown that with a sudden change in the diameter of a tube or in the direction of the flow, the slowermoving fluid near the wall stops or reverses direction, which is known as boundary layer separation (BLS). We hypothesized that a sudden change in the diameter of elastic vessel that results from compression may lead not only to BLS but also to other hemodynamic changes that can damage endothelium.

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“…[8], who introduced the concept of compliance mismatch between graft and artery as the cause of DAIH, has attracted significant attention of graft manufacturers to improve graft quality. Imparato et al [9], Fry [10], and several other investigators [11][12][13][14] bdieved that high frequency flow and shear stress are apt to cause endothelial injury and reactive subendothetiat fibrocotlagenous proliferation. Careful characterization and analysis of the shear stress at the anastomosis led Faulkner and others [14][15][16] to believe that DAIH was a sequela of abnormal fluid flow dynamic at the distal anastomosis.…”

Section: Discussionmentioning

confidence: 99%

Distal anastomotic intimal hyperplasia: Histocytomorphology, pathophysiology, etiology, and prevention

Sottiurai¹

1999

Int J Angiol

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In vitro studies of local blood flow disturbance in a region of separation

Cited by 59 publications

References 3 publications

Flow studies in a model carotid bifurcation.

Flow studies in a model carotid bifurcation.

Blunt trauma to large vessels: a mathematical study

Distal anastomotic intimal hyperplasia: Histocytomorphology, pathophysiology, etiology, and prevention

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