In Vitro Studies in Reproductive Immunology, 3. Restoration of Mitogenic Activity of Lymphocytes Inhibited by Seminal Plasma in Man

Marcus, Zvi H.; Hess, Evelyn V.

doi:10.3109/01485018108987348

Cited by 12 publications

(3 citation statements)

References 11 publications

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“…The free fraction of the inhibitory factor will consequently vary in concentration and thus activity. Normozoospermic semen will tend to cause less suppression of the lymphocytes than qeminal plasma from an azoospermic male [7].…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of Lymphocytes by Seminal Plasma Fractions from Azo-, Oligo- and Normozoospermic Men

Franken

Toit

Slabber

et al. 1982

Archives of Andrology

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Human seminal plasma specimens from 62 patients were collected and divided into three groups according to their fertility state. Five protein peaks, obtained by column chromatography, were used in lymphocyte transformation studies to measure their effect on blast transformation rates. The results expressed as percentage inhibition showed that the immunosuppressive activity of isolated seminal plasma fractions were more marked than whole seminal plasma. There was no statistical correlation between inhibition caused by each fraction and the fertility state of the patient groups. Inhibitory components do not seem to relate to the amount of sperm cells in the ejaculate.

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Section: Discussionmentioning

confidence: 99%

“…although there was greater inhibition with seminal plasma fractions than with whole seminal plasma. It may be necessary to isolate the inhibitory component of human seminal plasma to demonstrate individual differences in the immunosuppressive activity of seminal plasma [ 7 ] .…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Lymphocytes by Seminal Plasma Fractions from Azo-, Oligo- and Normozoospermic Men

Franken

Toit

Slabber

et al. 1982

Archives of Andrology

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“…Fractionation studies have shown that large proteins, some of which are of vesicular origin, are involved (Lord, Sensabaugh & Stites, 1977;Marcus & Hess, 1981;Stites & Erickson, 1975;.…”

Section: Action Of Vesicular Secretions On the Female Genital Apparatusmentioning

confidence: 99%

Functions of the seminal vesicle: Funktionen der Bläschendrüse

Clavert¹,

Cranz²,

Bollack³

2009

Andrologia

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Summary The seminal vesicle is a gland which appeared late in the evolution of placental mammals. Vesiculectomy leads to very serious subfertility demonstrating the important role of this gland. Secretions of the seminal vesicle act during coitus and the maturation of the spermatozoon, on its mobility, its freezing capacity and the condensation of chromatin. These secretions also act on the female genital tract because they possess immunodepressive capacity. Due to their high concentration of prostaglandins, they can modify the contraction of smooth muscle. As shown by the animal model, they have an antibacterial role in the male genital tract. This explains the relatively low frequency of purely vesicular infections in human pathology. Zusammenfassung Die Bläschendrüse ist eine Drüse, die spät in der Evolution der placentalen Mammalier erschien. Entfernung der Bläschendrüse führt zu sehr schwerer Subfertilität und zeigt so die bedeutende Rolle dieser Drüse. Das Bläschendrüsensekret wirkt auf die Ausreifung der Spermien und postkoital auf die Spermienmobilität, die Einfrierkapazität und die Chromatinkondensation. Das Sekret wirkt auch auf den weiblichen Genitaltrakt und besitzt dort immunsuppressive Wirkung. Aufgrund des hohen Prostaglandingehalts kann es die Kontraktion der glatten Muskulatur modifizieren. Wie im Tiermodell gezeigt, hat das Bläschendrüsensekret eine antibakterielle Wirkung auch im männlichen Genitaltrakt. Dies erklärt die verhältnismäßig geringe Häufigkeit reiner Bläschendrüsen‐Infektionen in der menschlichen Pathologie.

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Seminal Plasma Hypersensitivity Reactions: An Updated Review

Sublett

Bernstein

2011

Mount Sinai J Medicine

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Seminal plasma hypersensitivity manifests as a spectrum of systemic and/or localized clinical symptoms after exposure to specific protein components in seminal fluid. The prevalence of this disease is largely unknown, but it is believed to affect up to 40,000 women in the United States. Although no definitive risk factors have been confirmed, women with systemic reactions are frequently atopic. Prostate-specific antigen is believed to be the major allergen involved in the disorder, but other proteins are likely involved. Interestingly, up to 40%-50% of both systemic and localized seminal plasma hypersensitivity cases can occur after first-time intercourse. Diagnosis is based on clinical history. The gold standard for diagnosing seminal plasma hypersensitivity is prevention of symptoms with the use of a condom. Patients with seminal plasma hypersensitivity demonstrate positive prick skin test and/or serum-specific immunoglobulin E to whole seminal fluid or fractionated seminal plasma proteins. Treatment of seminal plasma hypersensitivity involves either avoidance with the use of condoms, intravaginal graded challenge using dilutions of whole seminal fluid, or subcutaneous desensitization to relevant fractionated seminal plasma proteins obtained from the woman's sexual partner. In most cases, treatment using one or more of the above approaches has been very successful. Infertility has not been demonstrated to be directly related to seminal plasma hypersensitivity, although women with the condition frequently have difficulty conceiving due to their inability to have unprotected sexual intercourse.

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In Vitro Studies in Reproductive Immunology, 3. Restoration of Mitogenic Activity of Lymphocytes Inhibited by Seminal Plasma in Man

Cited by 12 publications

References 11 publications

Inhibition of Lymphocytes by Seminal Plasma Fractions from Azo-, Oligo- and Normozoospermic Men

Inhibition of Lymphocytes by Seminal Plasma Fractions from Azo-, Oligo- and Normozoospermic Men

Functions of the seminal vesicle: Funktionen der Bläschendrüse

Seminal Plasma Hypersensitivity Reactions: An Updated Review

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