In vitro stability study of organosilane self-assemble monolayers and multilayers

Wang, Anfeng; Tang, Haiying; Cao, Ting; Salley, Steven O.; Ng, Koon‐Kwan

doi:10.1016/j.jcis.2005.05.008

Cited by 81 publications

(98 citation statements)

References 35 publications

(49 reference statements)

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“…4-Aminophenylmethylphosphonate, 4-phenylenediamine, tert-butylnitrite, potassium carbonate (K 2 CO 3 ) sodium nitrite (NaNO 2 ), potassium chloride (KCl), potassium dihydrogen phosphate (KH 2 PO 4 ), potassium phosphate dibasic (K 2 HPO 4 ), fluoroboric acid, potassium ferricyanide (K 3 Fe(CN) 6 ), ruthenium(III) hexamine chloride (Ru-(NH 3 ) 6 Cl 3 ), acetonitrile (ACN) and methanol (CH 3 OH) were obtained from Sigma-Aldrich (Sydney, Australia). Sodium hydroxide (NaOH) and hydrochloric acid (HCl, 32 %) were obtained from Ajax Finechem (Sydney, Australia).…”

Section: Reagents and Materialsmentioning

confidence: 99%

“…The modification of ITO has typically been performed using organosilane chemistry [5]. However the lability of such chemistry [6], especially in aqueous solutions [7], has motivated us to investigate other methods of modifying ITO. Two recent methods of modifying ITO that have begun to attract interest has been using organophosphonate [8] molecules that give well defined monolayers on ITO surfaces and aryl diazonium salt derived layers that are highly stable on many materials [9].…”

Section: Introductionmentioning

confidence: 99%

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A Molecule with Dual Functionality 4‐Aminophenylmethylphosphonic Acid: A Comparison Between Layers Formed on Indium Tin Oxide by In Situ Generation of an Aryl Diazonium Salt or by Self‐Assembly of the Phosphonic Acid

et al. 2011

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4-Aminophenylmethylphosphonic acid was grafted on ITO surfaces by 1) electrochemical reductive adsorption of the corresponding aryl diazonium salt and 2) by self-assembly via the phosphonic acid moiety. The aryl diazonium salt derived surfaces are reasonably stable within a wide potential range from À600 mV to 600 mV compared to a very narrow stable range between À40 mV and 40 mV for the self-assembled layers. The different surface stabilities were assessed with a view to forming ITO-organic layer-gold nanoparticle (AuNPs) constructs. As expected the ITO-organic layer-AuNPs construct formed by electrochemical adsorption (ITO-Ph-AuNP) was significantly more stable than the construct formed by self-assembly of phosphonates (ITO-PO 3 Ph-AuNPs).

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Section: Reagents and Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Molecule with Dual Functionality 4‐Aminophenylmethylphosphonic Acid: A Comparison Between Layers Formed on Indium Tin Oxide by In Situ Generation of an Aryl Diazonium Salt or by Self‐Assembly of the Phosphonic Acid

et al. 2011

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“…The stability of the AEG3 SAMs was apparently good which is in good agreement with WANG et al who reported increasing stability of amino-terminated SAMs the longer the intramolecular spacer between head and tail group. [152] A high stability of the coating is crucial for the peptide array synthesis and subsequent biological applications. Furthermore, a high CC-O:CC-C ratio and a high NN-H peak in XPS are critical parameters which seem to hint at a high loading of functional groups.…”

Section: Discussionmentioning

confidence: 99%

Purification of Peptides in High-Complexity Arrays

Schirwitz

2013

Springer Theses

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Compared to the human genome, which is formed by approximately 25,000 genes, the human proteome comprises over a million functional proteins and thus represents a much higher diversity. Although genetic research provides valuable information on the proteins which can be translated, a great task in the future will be the exploration of the entire protein interaction network. Understanding protein interactions will greatly help scientists to identify the mechanisms behind fatal diseases such as cancer, AIDS, and tuberculosis and, hopefully, provide new

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“…In the case of oxidized silicon, the silanization reaction takes place most commonly in toluene at room temperature for several hours [21,22]. Very few studies are devoted to the stability of PEG-derivatized silicon (and none about germanium), under conditions mimicking physiological media used for biosensor detection [23,24]. Nevertheless, it appears that such devices are not highly stable in phosphate buffered saline (PBS) and that the loss of PEGs most probably results from basic hydrolysis of the Si-O bonds within the interface oxide layer [25].…”

Section: Design and Synthesis Of The Organic Reagentmentioning

confidence: 99%

Surface functionalization of germanium ATR devices for use in FTIR-biosensors

Devouge

Conti

Goldsztein

et al. 2009

Journal of Colloid and Interface Science

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Biosensors based on intrinsic detection methods have attracted growing interest. The use of Fourier transform infra-red (FTIR) spectroscopy with the attenuated internal total reflection (ATR) mode, in the biodetection context, requires appropriate surface functionalization of the ATR optical element. Here, we report the direct grafting of a thin organic layer (about 20 Å depth) on the surface of a germanium crystal. This covering, constructed with novel amphiphilic molecules 2b (namely, 2,5,8,11,14,17,20-heptaoxadocosan-22-yl-3-(triethoxysilyl) propylcarbamate), is stable for several hours under phosphate buffered saline (PBS) flux and features protein-repulsive properties. Photografting of molecule 5 (namely, O-succinimidyl 4-(p-azidophenyl)butanoate) affords the activated ATR element, ready for the covalent fixation of receptors, penicillin recognizing proteins BlaR-CTD for instance. The different steps of the previous construction have been monitored by water contact angle (θ w ) measurements, spectroscopic ellipsometry (covering depth), X-ray photoelectron spectroscopy (XPS) by using a fluorinated tag for the control of surface reactivity, and FTIR-ATR spectroscopy for the structural analysis of grafted molecules. Indeed, contrarily to silicon device, germanium device offers a broad spectral window (1000-4000 cm −1 ) and thus amide I and II absorption bands can be recorded. This work lays the foundations for the construction of novel FTIR biosensors.

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In vitro stability study of organosilane self-assemble monolayers and multilayers

Cited by 81 publications

References 35 publications

A Molecule with Dual Functionality 4‐Aminophenylmethylphosphonic Acid: A Comparison Between Layers Formed on Indium Tin Oxide by In Situ Generation of an Aryl Diazonium Salt or by Self‐Assembly of the Phosphonic Acid

A Molecule with Dual Functionality 4‐Aminophenylmethylphosphonic Acid: A Comparison Between Layers Formed on Indium Tin Oxide by In Situ Generation of an Aryl Diazonium Salt or by Self‐Assembly of the Phosphonic Acid

Purification of Peptides in High-Complexity Arrays

Surface functionalization of germanium ATR devices for use in FTIR-biosensors

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