In vitro skin absorption tests of three types of parabens using a Franz diffusion cell

Seo, Jiyeon; Kim, Sungkyoon; Kim, Bae-Hwan

doi:10.1038/jes.2016.33

Cited by 38 publications

(26 citation statements)

References 39 publications

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“…To assess transcutaneous permeation kinetics of drug surrogate encapsulated TI-DMNs, we utilized a diffusion cell apparatus, which mimics the biological environment of human skin in vitro 38,39 . DMNs were applied on pig cadaver skin placed over the diffusion cell apparatus and measured the amount of delivered drug surrogate up to 120 min.…”

Section: Resultsmentioning

confidence: 99%

Tissue Interlocking Dissolving Microneedles for Accurate and Efficient Transdermal Delivery of Biomolecules

Lahiji

Kim

Kang

et al. 2019

Sci Rep

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The interest in safe and efficient transdermal drug delivery systems has been increasing in recent decades. In light of that, polymeric dissolving microneedles (DMNs) were developed as an ideal platform capable of delivering micro- and macro-biomolecules across the skin in a minimally invasive manner. A vast majority of studies, however, suggest that the shape of DMNs, as well as the elastic properties of skin, affects the delivery efficiency of materials encapsulated within DMNs. Likewise, in dynamic tissues, DMNs would easily distend from the skin, leading to inefficient delivery of encapsulated agents. Thus, herein, to improve delivery efficiency of DMN encapsulated agents, a novel hyaluronic acid backbone-based tissue interlocking DMN (TI-DMN) is developed. TI-DMN is simple to fabricate and significantly improves the transdermal delivery efficiency of encapsulated materials compared with traditional DMNs. The enhanced tissue interlocking feature of TI-DMN is achieved through its sharp tip, wide body, and narrow neck geometry. This paper demonstrates that TI-DMN would serve as an attractive transdermal delivery platform to enhance penetration and delivery efficiency of a wide range of biomolecules into the body.

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Section: Resultsmentioning

confidence: 99%

Tissue Interlocking Dissolving Microneedles for Accurate and Efficient Transdermal Delivery of Biomolecules

Lahiji

Kim

Kang

et al. 2019

Sci Rep

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“…The prepared skin was mounted between the donor and receptor compartments of the diffusion cells with the dermal side in direct contact with the receptor medium. Transdermal films were placed between donor and acceptor chambers and allowed to be diffused through excised rat skin to phosphate-buffered saline (receptor medium, 7 mL, pH (7) stirred at 400 rpm, maintained at 32°C±0.5°C to correspond to normal human skin temperature [28,29], and contains 0.05% sodium dodecyl sulfate to maintain sink condition [30]. Aliquots (2 mL) were collected at 0.5, 1, 2, 4, 8, and 12 h.…”

Section: Methodsmentioning

confidence: 99%

Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved transdermal delivery of raloxifene

2019

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Raloxifene is commonly used for breast cancer protection. The low bioavailability of raloxifene (2%) is the result of its low solubility and intestinal glucuronidation. The nano-lipid carriers are characterized by small particle size, biocompatibility, and sustainable properties that improve cellular uptake of the loaded drug. The aim of this study was the improvement of raloxifene bioavailability by enhancing its solubility and cellular penetration through formulation of D-α-tocopheryl polyethylene glycol 1000 succinate based transferosomes and augmenting their effect with the cationic cell-penetrating peptide transactivator of transcription of the human immunodeficiency virus. Particle size, zeta potential, and transmission electron microscope investigation of the formed nanocarriers were carried out. Ex vivo raloxifene permeation through rat skin and cell viability studies was investigated. The results of D-α-tocopheryl polyethylene glycol 1000 succinate- transactivator of transcription of the human immunodeficiency virus transferosomes showed an average vesicle size of 96.05 nm with positively charged vesicles 39.4 mV of zeta potential value. The results revealed significant (p < 0.05) enhancement of raloxifene permeation from raloxifene transferosomes- loaded film when compared with raw raloxifene film. IC50 results showed significant improvement of formulated raloxifene cytotoxicity by 1.42-fold in comparison with raw raloxifene against MCF-7 cell lines. The developed raloxifene—transferosomes are considered promising nano-lipid carriers for the enhancement delivery of raloxifene.

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“…Exposure to phthalates and parabens from PCP use occurs through direct dermal application ( Janjua et al 2008 ; Seo et al 2016 ), inhalation, oral ingestion, or even transdermal exposure from air ( Weschler et al 2015 ). Phthalates and parabens have short biological half-lives (6–24 h) ( Janjua et al 2008 ; Koch et al 2012 ; Moos et al 2016 ), and urinary concentrations of phthalate metabolites and parabens are the preferred exposure biomarkers ( Calafat et al 2015 ; CDC 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study

Nassan

Coull

Gaskins

et al. 2017

Environ Health Perspect

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Background:Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men’s exposure is understudied.Objectives:We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men.Methods:In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004–2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use.Results:Four hundred men contributed 1,037 urine samples (mean of 3/man). The largest percent increase in monoethyl phthalate (MEP) was associated with use of cologne/perfume (83%, p-value<0.01) and deodorant (74%, p-value<0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66–156%) and hand/body lotion (79–147%). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254–1,333% increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant.Conclusions:We identified 10 PCPs of relevance and demonstrated that their use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. https://doi.org/10.1289/EHP1374

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In vitro skin absorption tests of three types of parabens using a Franz diffusion cell

Cited by 38 publications

References 39 publications

Tissue Interlocking Dissolving Microneedles for Accurate and Efficient Transdermal Delivery of Biomolecules

Tissue Interlocking Dissolving Microneedles for Accurate and Efficient Transdermal Delivery of Biomolecules

Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved transdermal delivery of raloxifene

Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study

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