In-Vitro Restoration by Levamisole of Thymus-Derived Lymphocyte Function in Hodgkin's Disease

Effect of levamisole and azathioprine on the human mixed lymphocyte reaction (MLR).

“…Levamisole has been shown to reverse azathioprine inhibitory effects on rosette formation (Verhaegen et al, 1975;1977) of healthy and cancer patients but the inhibitory effect was only 10% and on antigen (Veillonella) stimulated lymphocytes (Ivanyi, 1979). However, our results demonstrated that levamisole did not affect azathioprine suppression of the MLR.…”

“…It has also been found to reverse the inhibitory effect of azathioprine on rosette formation (Verhaegen et al, 1975(Verhaegen et al, , 1977 and antigen stimulated lymphocytes (Ivanyi, 1979) but its effect on the MLR has not been studied. Here we report the effect of levamisole alone and together with azathioprine on human MLR.…”

Effects of Levamisole in Sézary Syndrome

“…Atypical cells are also found in peri pheral blood and have recently been identified as helper T-lymphocytes [13]. Variable degrees of immunologic incompetence may be present.…”

Klassische Synthese von Thymopoietin 32-36 (TP 5) unter Verwendung der säurelabilen 1- (1 -Adamantyl) -1 -methylethoxycarbonyl- Schutzgruppe+ / Conventional Synthesis of Thymopoietin 32-36 (TP 5) Using the 1 -(1 - Adamantyl)-1 -methylethoxycarbonyl Group

“…Die Frage nach kleineren Peptiden, welche dieselben Effekte bezüglich des Immunsystems besitzen, führten zu dem Thymopoietin 32-36 (TP5). Sowohl Goldstein [5] als auch Verhaegen [6] synthetisierten TP5, ohne jedoch Details über den Synthese verlauf anzugeben. Über eine Festphasensynthese von TP5 wurde ebenfalls schon berichtet [7].…”