In vitro Response of Human Mesenchymal Stromal Cells to Titanium Coated Peek Films and Their Suitability for Magnetic Resonance Imaging

Elschner, Cindy; Noack, Carolin; Preissler, Carolin; Krause, Andreas; Scheler, Ulrich; Hempel, Ute

doi:10.1016/j.jmst.2014.10.012

Cited by 12 publications

(8 citation statements)

References 43 publications

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“…However, the release of Al and V ions from the dissolution of the passive film on the alloy surfaces produces a toxic effect, causing severe health problems [14,15]. For this reason, the non-allergic and non-toxic beta-eutectic (b) elements such as niobium (Nb) and iron (Fe) have been used as safe alloying elements for developing low elastic modulus and high-strength titanium alloys [16,17]. The Ti alloy with aluminum and iron is found to be more suitable for implant applications [17].…”

Section: Introductionmentioning

confidence: 99%

Effect of Replacing Vanadium by Niobium and Iron on the Tribological Behavior of HIPed Titanium Alloys

Fellah

Aissani

Samad

et al. 2017

Acta Metall. Sin. (Engl. Lett.)

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This study aims to examine the effect of replacing vanadium by niobium and iron on the tribological behavior of hot-isostatic-pressed titanium alloy (Ti-6Al-4V) biomaterial, using a ball-on-disk-type oscillating tribometer, under wet conditions using physiological solution in accordance with the ISO7148 standards. The tests were carried out under a normal load of 6 N, with an AISI 52100 grade steel ball as a counter face. The morphological changes and structural evolution of the nanoparticle powders using different milling times (2, 6, 12 and 18 h) were studied. The morphological characterization indicated that the particle and crystallite size continuously decrease with increasing milling time to reach the lowest value of 4 nm at 18-h milling. The friction coefficient and wear rate were lower in the samples milled at 18 h (0.226, 0.297 and 0.423; and 0.66 9 10 -2 , 0.87 9 10 -2 and 1.51 9 10 -2 lm 3 N -1 lm -1 ) for Ti-6Al-4Fe, Ti-6Al-7Nb and Ti-6Al-4V, respectively. This improvement in friction and wear resistance is attributed to the grain refinement at 18-h milling. The Ti-6Al-4Fe samples showed good tribological performance for all milling times.

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Section: Introductionmentioning

confidence: 99%

Effect of Replacing Vanadium by Niobium and Iron on the Tribological Behavior of HIPed Titanium Alloys

Fellah

Aissani

Samad

et al. 2017

Acta Metall. Sin. (Engl. Lett.)

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“…Biopolymer polyetheretherketone (PEEK) exhibits poor bioactivity and limited bone binding ability 1 2 in spite of good biocompatibility, mechanical compatibility and processing properties 3 4 5 . Hydroxyapatite (HAP) is a bioceramic material that has good biocompatibility and bioactivity, and can form a strong bonding with bone tissue 6 7 8 .…”

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confidence: 99%

Graphene oxide as an interface phase between polyetheretherketone and hydroxyapatite for tissue engineering scaffolds

Peng

Feng

et al. 2017

Sci Rep

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The poor bonding strength between biopolymer and bioceramic has remained an unsolved issue. In this study, graphene oxide (GO) was introduced as an interface phase to improve the interfacial bonding between polyetheretherketone (PEEK) and hydroxyapatite (HAP) for tissue engineering scaffolds. On the one hand, the conjugated structure of GO could form strong π-π stacking interaction with the benzene rings in PEEK. On the other hand, GO with a negatively charge resulting from oxygen functional groups could adsorb the positively charged calcium atoms (C sites) of HAP. Consequently, the dispersibility and compatibility of HAP in the PEEK matrix increased with increasing GO content up to 1 wt%. At this time, the compressive strength and modulus of scaffolds increased by 79.45% and 42.07%, respectively. Furthermore, the PEEK-HAP with GO (PEEK-HAP/GO) scaffolds possessed the ability to induce formation of bone-like apatite. And they could support cellular adhesion, proliferation as well as osteogenic differentiation. More importantly, in vivo bone defect repair experiments showed that new bone formed throughout the scaffolds at 60 days after implantation. All these results suggested that the PEEK-HAP/GO scaffolds have a promising potential for bone tissue engineering application.

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“…All samples, planar and TS with TNO exhibited lower contact angles (40°–70°) compared to the SOA samples (75°–90°) (Figure 1f), being the ones of TNO in the optimal range for enhanced surface adhesion of extracellular matrix proteins. [ 45 ]…”

Section: Resultsmentioning

confidence: 99%

“…All samples, planar and TS with TNO exhibited lower contact angles (40°-70°) compared to the SOA samples (75°-90°) ( Figure 1f), being the ones of TNO in the optimal range for enhanced surface adhesion of extracellular matrix proteins. [45] Subsequently, the chemical and structural state of the sputter deposited layers were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Figure 1g (inset, left) shows an exemplary grazing incidence XRD pattern of a TNO thin layer.…”

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confidence: 99%

Rolled‐Up Metal Oxide Microscaffolds to Study Early Bone Formation at Single Cell Resolution

Herzer

Gebert

Hempel

et al. 2021

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demand for new hard tissue implants which better fulfill patient-specific needs regarding their mechanical properties and biocompatibility. In the fields of orthopedics and trauma surgery, a key focus is the development of new metallic materials for load-bearing implants with reduced stiffness, similar to that of bone, to diminish stress shielding and to improve their longterm stability. A new class of β-stabilized TiNb alloys has shown great potential in the last decade to fulfill some of these requirements. [2,3] In bulk alloys, for example, the high content of Nb stabilizes the beta-phase, leading to very low elastic modulus values (60-65 GPa), closer to that of cortical bone (with up to 30 GPa). [4] Likewise, porous Ti-(40-45)Nb (wt%) scaffolds induce lower structural stiffness below 10 GPa, being comparable to that of spongy bone. The pore size of these implants strongly depends on the specific synthesis parameters and the applied fabrication technique (e.g., powder bed fusion or powder metallurgy), ranging from few to hundreds of micrometers. [5,6] While various studies conclude that bone ingrowth promotion occurs in the range of 100-600 µm pore size, [7-9] a consensus regarding the optimal pore dimensions has not been reached in the scientific community yet, as it is always superimposed with other scaffold parameters.

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In vitro Response of Human Mesenchymal Stromal Cells to Titanium Coated Peek Films and Their Suitability for Magnetic Resonance Imaging

Cited by 12 publications

References 43 publications

Effect of Replacing Vanadium by Niobium and Iron on the Tribological Behavior of HIPed Titanium Alloys

Effect of Replacing Vanadium by Niobium and Iron on the Tribological Behavior of HIPed Titanium Alloys

Graphene oxide as an interface phase between polyetheretherketone and hydroxyapatite for tissue engineering scaffolds

Rolled‐Up Metal Oxide Microscaffolds to Study Early Bone Formation at Single Cell Resolution

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